Patents by Inventor Neil T. Parkin

Neil T. Parkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel recombinant tryptophan mutants of influenza
    Publication number: 20020119445
    Abstract: Recombinant PB2 tryptophan variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such viruses and methods for the prophylactic treatment of influenza in humans.
    Type: Application
    Filed: November 26, 2001
    Publication date: August 29, 2002
    Inventor: Neil T. Parkin
  • Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Publication number: 20020094522
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) and further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy, particularly non-nucleoside reverse transcriptase inhibitor therapy using phenotypic susceptibility assays or genotypic assays.
    Type: Application
    Filed: September 14, 2001
    Publication date: July 18, 2002
    Inventors: Jeannette Whitcomb, Neil T. Parkin, Gabrielle Heilek-Snyder
  • Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Publication number: 20020064838
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
    Type: Application
    Filed: January 19, 2001
    Publication date: May 30, 2002
    Inventors: Neil T. Parkin, Rainer A. Ziermann
  • COMPOSITIONS AND METHODS FOR DETERMINING ANTI-VIRAL DRUG SUSCEPTIBILITY AND RESISTANCE AND ANTI-VIRAL DRUG SCREENING
    Publication number: 20020034732
    Abstract: This invention provides a method for determining susceptibility for an HCV or HCMV anti-viral drug comprising: (a) introducing a resistance test vector comprising a patient-derived segment and an indicator gene into a host cell; (b) culturing the host cell from (a); (c) measuring expression of the indicator gene in a target host cell; and (d) comparing the expression of the indicator gene from (c) with the expression of the indicator gene measured when steps (a)-(c) are carried out in the absence of the anti-viral drug, wherein a test concentration of the anti-viral drug is present at steps (a)-(c); at steps (b)-(c); or at step (c).
    Type: Application
    Filed: July 30, 1998
    Publication date: March 21, 2002
    Inventors: DANIEL J. CAPON, JEANNETTE M. WHITCOMB, NEIL T. PARKIN
  • Recombinant tryptophan mutants of influenza
    Patent number: 6322967
    Abstract: Recombinant PB2 tryptophan variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such viruses and methods for the prophylactic treatment of influenza in humans.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: November 27, 2001
    Assignee: Aviron
    Inventor: Neil T. Parkin
  • Recombinant tryptophan mutants of influenza
    Patent number: 6090391
    Abstract: Recombinant PB2 tryptophan variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such viruses and methods for the prophylactic treatment of influenza in humans.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: July 18, 2000
    Assignee: Aviron
    Inventor: Neil T. Parkin
  • Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene
    Patent number: 5690937
    Abstract: Recombinant PB2 variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such viruses and methods for the prophylactic treatment of influenza in humans.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 25, 1997
    Assignee: Aviron
    Inventors: Neil T. Parkin, Kathleen L. Coelingh