Abstract: A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.

Abstract: A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.

Abstract: A medical device including a pouch including a first portion of a flexible metal foil bonded to a second portion of the flexible metal foil to define a hermetically sealed interior volume, electronic components in the hermetically sealed interior volume, and a case around the pouch. The medical device can be designed to be rigid or have one or more flexible regions.

Abstract: An implantable medical system includes a medical device connected to a medical lead with several neural interfaces. The system can selectively generate stimulation signals at a selected one of the several neural interfaces, such as nerve cuffs. Each neural interface has at least one working electrode that is common to all the neural interfaces. Each neural interface has at least one reference electrode that is dedicated to that interface. A neural interface that has not been selected to stimulate tissue has its dedicated reference electrode floating with respect to power and ground.

Abstract: A lead splitter adapter for an implantable pulse generator includes a plug portion configured to plug into a receptacle of an implantable pulse generator. The plug portion includes electrical contacts, and at least two of the electrical contacts, a first electrical contact from within the first lead receptacle and a second electrical contact from the second lead receptacle, which first and second electrical contacts are shunted by an electrical connection that includes at least one of a resistor, capacitor or inductor.

Abstract: A stimulation system includes an implantable medical device (IMD) configured to provide electrical stimulation to tissue; a controller configured to control the electrical stimulation provided by the IMD; an implantable sensor configured to measure first heart rate data and to transmit the first heart rate data to the controller; an external sensor configured to measure second heart rate data and to transmit the second heart rate data to the controller; and an external electronic device communicatively coupled to the IMD, wherein the controller is configured to selectively operate the IMD in an internal sensor mode, whereby the controller controls the electrical stimulation provided by the IMD based on the first heart rate data, or an external sensor mode, whereby the controller controls the electrical stimulation provided by the IMD based on the second heart rate data.

Abstract: An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

Abstract: A step-down adapter for an implantable pulse generator includes a plug portion configured to plug into a receptacle of an implantable pulse generator. The plug portion includes electrical contacts, and at least two of the electrical contacts are shorted together. The step-down adapter also includes a receptacle portion connected to the plug portion. The receptacle portion includes electrical contacts, and the receptacle portion is configured to receive a proximal portion of an electrical stimulation lead.

Abstract: An implantable medical system includes a medical device connected to a medical lead with several neural interfaces. The system can selectively generate stimulation signals or sense neurological signals at a selected one of several neural interfaces, such as nerve cuffs. Each neural interface has at least one working electrode that is common to all the neural interfaces. Each neural interface has at least one reference electrode that is dedicated to that interface. A neural interface that has not been selected to stimulate tissue or to sense neurological signals has its dedicated reference electrode floating and not connected to power, ground or any electronic system. Any electrodes that were used for stimulation and are about to be used for neural sensing are grounded for a time interval to discharge any residual electrical charges that may remain due to neural stimulation signals.

Abstract: The present disclosure relates to systems and methods for therapeutic nerve stimulation, particularly systems based on vibratory stimulation. Vibratory stimulation offers multiple advantages over other minimally or non-invasive neuromodulation techniques. In some aspects, the disclosure provides minimally invasive neuromodulation devices that can deliver stimulation when placed on the skin, as well as configurations that utilize percutaneous structures that extend into the body below the surface of the skin to transfer vibrational energy into the body.

Abstract: A medical device includes an implantable pulse generator (IPG), and the IPG includes a driver configured to generate a stimulation current having a duty cycle; a memory storing instructions; and a microcontroller circuit operatively coupled to the driver and to the memory, and configured, in response to executing the instructions stored in the memory, to cause the driver to vary the duty cycle based at least in part by a time-variable primary duty cycle transfer function.

Abstract: An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

Abstract: A method of treating obstructive sleep apnea in a patient includes measuring, with electrodes, thoracic impedance of the patient, and stimulating, with a nerve stimulation device implanted in the patient, a nerve of patient based on the thoracic impedance. The nerve is associated with sleep apnea, such as the hypoglossal nerve and/or the ansa cervicalis nerve. The electrodes may be either surface electrodes or implanted electrodes, and the thoracic impedance may be trans-thoracic impedance or intra-thoracic impedance.

Abstract: A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and MgSulfate blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the MgSulfate blasted front surfaces are within the windows.

Abstract: An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

Abstract: An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

Abstract: A medical device includes: one or more stimulation leads configured to stimulate at least a person's vagus nerve to treat, via the stimulation of the person's vagus nerve, both obesity and one or more medical conditions comorbid with the obesity; and a controller coupled to the one or more stimulation leads and configured to control and drive the stimulation provided by the one or more stimulation leads.

Abstract: A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.

Abstract: The present disclosure generally relates to systems and methods for a stimulation system. Various aspects of the present disclosure relate generally to the treatment of epilepsy, depression and/or other conditions in a subject using a nerve stimulator and, more particularly, to an effective and quicker titration method for selection of stimulation parameters of the nerve stimulator using biological markers that indicate potential therapeutic effects. Some aspects of the present disclosure may utilize a pupillometry sensor synchronized with the VNS stimulation system to compare pupil size of a subject with stimulation on and off and for obtaining filtered pupil response measurements after stimulating each electrode while modulating the stimulation parameters. Thus, aspects of the present disclosure allow for quicker titration of programmable stimulation parameters (e.g.

Abstract: A stimulation device includes a first transmitting coil and a drive circuit electrically coupled to the first transmitting coil and configured to drive the first transmitting coil. The first transmitting coil is configured, when the device is in proximity to a person's ear and the first transmitting coil is driven with a time-varying electric current providable by the drive circuit, to generate at least part of a magnetic field providing a time-varying magnetic flux across an auricular branch of a Vagus Nerve (ABVN) sufficient to activate the ABVN.