Patents by Inventor Neil Tremayne

Neil Tremayne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation and uses of pyrimidinone derivatives
    Patent number: 10919896
    Abstract: The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: wherein X, R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: February 16, 2021
    Assignee: Cancer Research Technology Limited
    Inventors: Emma L. Carswell, Mark David Charles, Anne Cochi, Benjamin J. Dugan, Chukuemeka Tennyson Ekwuru, Fred Elustondo, Katherine M. Fowler, Frederic Georges Marie Leroux, Nathaniel J. T. Monck, Gregory R. Ott, Jonathan R. Roffey, Gurwinder Sidhu, Neil Tremayne
  • PREPARATION AND USES OF PYRIMIDINONE DERIVATIVE
    Publication number: 20200123157
    Abstract: The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: wherein X, R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
    Type: Application
    Filed: September 22, 2017
    Publication date: April 23, 2020
    Inventors: Emma L. Carswell, Mark David Charles, Anne Cochi, Benjamin J. Dugan, Chukuemeka Tennyson Ekwuru, Fred Elustondo, Katherine M. Fowler, Frederic Georges Marie Leroux, Nathaniel J.T. Monck, Gregory R. Ott, Jonathan R. Roffey, Gurwinder Sidhu, Neil Tremayne
  • Process for Preparing 1-Halo-2,7-Naphthyridinyl Derivatives
    Publication number: 20090221828
    Abstract: A process for preparing 1-halo-2,7-naphthyridinyl derivatives is described (I), wherein X is Cl or Br; which process comprises the following steps: (i) reaction of a 3-cyano-4-methylpyridine derivative of formula (A): with a compound of formula (II), in the presence of an N,N-dimethylformamide diC1-6alkylacetal; to give an enamine derivative of formula (III), (ii) cyclisation of the enamine of formula (III), to obtain the compound of formula (IV), (iii) reaction of the compound of formula (IV) with a halogenating agent, to obtain a compound of formula (I).
    Type: Application
    Filed: March 21, 2007
    Publication date: September 3, 2009
    Applicant: UCB PHARMA, S.A.
    Inventors: Nicholas David Tyrrell, Neil Tremayne, Graham Robert Evans
  • Process for preparing 3-aminothienopyridone derivatives
    Patent number: 7482452
    Abstract: This invention provides a class of 3-amino-7H-thieno[2,3-b]pyridin-6-one derivatives, substituted in the 7-position by an aryl, heteroaryl, cycloalkyl or heterocycloalkyl moiety, and in the 2-position by a specified range of substituent groups; also provided is a process for preparing those compounds, and the use thereof as intermediates in the manufacture of certain p38 MAP kinase inhibitors.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: January 27, 2009
    Assignee: Celltech R&D Limited
    Inventors: Graham Robert Evans, Ian Harold Smith, Neil Tremayne, Leighton Jones, Marianne Langston
  • Process for preparing 3-aminothienopyridone derivatives
    Publication number: 20070191608
    Abstract: This invention provides a class of 3-amino-7H-thieno[2,3-b]pyridin-6-one derivatives, substituted in the 7-position by an aryl, heteroaryl, cycloalkyl or heterocycloalkyl moiety, and in the 2-position by a specified range of substituent groups; also provided is a process for preparing those compounds, and the use thereof as intermediates in the manufacture of certain p38 MAP kinase inhibitors.
    Type: Application
    Filed: June 18, 2004
    Publication date: August 16, 2007
    Applicant: CELLTECH R&D LIMITED
    Inventors: Graham Evans, Ian Smith, Neil Tremayne, Leighton Jones, Marianne Langston