Patents by Inventor Neil Vasdev

Neil Vasdev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11434203
    Abstract: The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single-photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: September 6, 2022
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Huan Steven Liang
  • Publication number: 20210024468
    Abstract: The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single-photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided.
    Type: Application
    Filed: August 19, 2020
    Publication date: January 28, 2021
    Inventors: Neil Vasdev, Huan Steven Liang
  • Patent number: 10781178
    Abstract: The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single-photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: September 22, 2020
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Huan Steven Liang
  • Patent number: 10280152
    Abstract: Provided herein are radiolabelled compounds useful for imaging GSK-3 kinase. An exemplary radiolabelled compound provided herein is useful as a radiotracer for imaging GSK-3 kinase using PET imaging. Methods for preparing the radiolabelled compounds and diagnostic methods using the radiolabelled compounds are also provided.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: May 7, 2019
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Huan Steven Liang
  • Patent number: 10259800
    Abstract: A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: April 16, 2019
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Benjamin H. Rotstein, Huan Steven Liang
  • Publication number: 20180370949
    Abstract: Provided herein are radiolabelled compounds useful for imaging GSK-3 kinase. An exemplary radiolabelled compound provided herein is useful as a radiotracer for imaging GSK-3 kinase using PET imaging. Methods for preparing the radiolabelled compounds and diagnostic methods using the radiolabelled compounds are also provided.
    Type: Application
    Filed: March 30, 2016
    Publication date: December 27, 2018
    Inventors: Neil Vasdev, Huan Steven Liang
  • Publication number: 20180327362
    Abstract: The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single-photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided.
    Type: Application
    Filed: February 9, 2016
    Publication date: November 15, 2018
    Inventors: Neil Vasdev, Huan Steven Liang
  • Publication number: 20180280551
    Abstract: Provided herein are methods for producing site specific PEG modifications to single domain antibodies (e.g., VHHs). Methods for producing site-specific ally conjugated bivalent single domain antibodies (e.g., VHHs) are also provided. Methods for labeling (e.g., with a fluorophore or radionuclide) site-specifically PEGylated single domain antibodies and site-specifically conjugated bivalent single domain antibodies are also provided.
    Type: Application
    Filed: October 1, 2016
    Publication date: October 4, 2018
    Applicants: Whitehead Institute for Biomedical Research, The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Mohammad Rashidian, Hidde L. Ploegh, Neil Vasdev, Huan Steven Liang
  • Patent number: 9957231
    Abstract: A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: May 1, 2018
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Benjamin H. Rotstein, Nickeisha A. Stephenson, Huan Liang
  • Publication number: 20170121300
    Abstract: A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.
    Type: Application
    Filed: May 26, 2016
    Publication date: May 4, 2017
    Inventors: Neil Vasdev, Benjamin H. Rotstein, Huan Steven Liang
  • Patent number: 9546167
    Abstract: This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18F]T807, using an unprotected or protected precursor (e.g., tert-butyl 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole-5-carboxylate).
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: January 17, 2017
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Timothy M. Shoup
  • Publication number: 20160362375
    Abstract: A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.
    Type: Application
    Filed: August 8, 2016
    Publication date: December 15, 2016
    Inventors: Neil Vasdev, Benjamin H. Rotstein, Nickeisha A. Stephenson, Huan Liang
  • Patent number: 9434699
    Abstract: A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: September 6, 2016
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Benjamin H. Rotstein, Nickeisha A. Stephenson, Huan Liang
  • Publication number: 20160214982
    Abstract: This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18F]T807, using an unprotected or protected precursor (e.g., tert-butyl 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole-5-carboxylate).
    Type: Application
    Filed: March 31, 2016
    Publication date: July 28, 2016
    Inventors: Neil Vasdev, Timothy M. Shoup
  • Publication number: 20160115162
    Abstract: This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18F]T807, using an unprotected or protected precursor (e.g., tertbutyl 7-(6-nitropyridin-3-yl)-SH-pyrido[4,3-b]indole-5-carboxylate). An improved one-step synthesis method to prepare [18F]T807 was achieved with a protected (e.g., t-BOC) precursor, offering increased solubility, a faster synthesis as well as simpler purification and automation. [18F]T807 was validated for human use with a GE TRACERlabâ„¢ FXFN radiosynthesis module. The methodology demonstrated herein should facilitate multi-center trials and widespread use for tauopathy imaging with this radiopharmaceutical.
    Type: Application
    Filed: May 30, 2014
    Publication date: April 28, 2016
    Inventors: Neil Vasdev, Timothy M. Shoup
  • Publication number: 20160061787
    Abstract: The disclosure relates to systems and methods for performing high performance liquid chromatography (HPLC) on a liquid sample. The methods include automatically, using a computer, controlling a liquid sample including a plurality of components to flow through a first flow path in a system for HPLC. Flowing through the first flow path includes flowing the liquid sample through a capture column. The capture column is capable of trapping at least some of the components of the liquid sample. The method includes automatically, using the computer, controlling a solvent to flow through a second flow path in the system for HPLC. Flowing through the second flow path includes flowing the solvent through the capture column to elute the trapped components from the capture column; flowing the solvent and eluted components through an analysis column capable of separating the eluted components; and flowing the separated components to a detector.
    Type: Application
    Filed: April 7, 2014
    Publication date: March 3, 2016
    Inventors: Neil Vasdev, Thomas Lee Collier
  • Publication number: 20150252007
    Abstract: A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.
    Type: Application
    Filed: March 6, 2015
    Publication date: September 10, 2015
    Inventors: Neil Vasdev, Benjamin H. Rotstein, Nickeisha A. Stephenson, Huan Liang