Abstract: Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

Abstract: A system for vibration-driven sensing may include a wearable dimensioned to be donned by a user of an artificial reality system. The system may also include a vibration sensor that is incorporated into the wearable and generates an electrical response that corresponds to a vibration detected at the wearable. The system may further include at least one processing device communicatively coupled to the vibration sensor. The processing device may determine, based at least in part on the electrical response generated by the vibration sensor, that the user has made a specific gesture with at least one body part. In response to this determination, the processing device may generate an input command for the artificial reality system based at least in part on the specific gesture made by the user. Various other systems and methods are also disclosed.

Abstract: A system for vibration-driven sensing may include a wearable dimensioned to be donned by a user of an artificial reality system. The system may also include a vibration sensor that is incorporated into the wearable and generates an electrical response that corresponds to a vibration detected at the wearable. The system may further include at least one processing device communicatively coupled to the vibration sensor. The processing device may determine, based at least in part on the electrical response generated by the vibration sensor, that the user has made a specific gesture with at least one body part. In response to this determination, the processing device may generate an input command for the artificial reality system based at least in part on the specific gesture made by the user. Various other systems and methods are also disclosed.

Abstract: A system for vibration-driven sensing may include a wearable dimensioned to be donned by a user of an artificial reality system. The system may also include a vibration sensor that is incorporated into the wearable and generates an electrical response that corresponds to a vibration detected at the wearable. The system may further include at least one processing device communicatively coupled to the vibration sensor. The processing device may determine, based at least in part on the electrical response generated by the vibration sensor, that the user has made a specific gesture with at least one body part. In response to this determination, the processing device may generate an input command for the artificial reality system based at least in part on the specific gesture made by the user. Various other systems and methods are also disclosed.