Abstract: Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. A method is also provided to reduce the incidence of genital tract infections caused by N. gonorrhoeae by administration of outer membrane vesicle preparations from N. gonorrhoeae and IL-12 incorporated in polymeric microspheres.

Abstract: Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. A method is also provided to reduce the incidence of genital tract infections caused by N. gonorrhoeae by administration of outer membrane vesicle preparations from N. gonorrhoeae and IL-12 incorporated in polymeric microspheres.

Abstract: Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. The invention relates to compositions comprising IL-12 and methods for using such compositions for treatment of genital tract infections. Infections that can be treated by the present method include those that are caused by N. gonorrhoeae, C. trachomatis or both.

Abstract: Compositions and methods for treating inflammatory disorders of the GI tract are provided. The compositions include a therapeutically effective amount of TGF? and ATRA (all-trans retinoic acid), in a pharmaceutically acceptable carrier suitable for oral administration. TGF? and ATRA are preferably encapsulated in microspheres. The compositions are useful in alleviating symptoms in subject with an inflammatory disease of the gastrointestinal tract. Exemplary subjects include subjects with Chrohns disease, ulcerative colitis, gastritis, irritable bowel syndrome, ileitis, etc. The composition is administered to the subject following a therapeutically effective regimen, for length of time resulting in an improvement in one or more symptoms associated with inflammatory disorders of the GI tract.

Abstract: Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. The invention relates to compositions comprising IL-12 and methods for using such compositions for treatment of genital tract infections. Infections that can be treated by the present method include those that are caused by N. gonorrhoeae, C. trachomatis or both.

Abstract: The invention relates to methods and products for preventing and treating tumors. In particular the invention relates to the use of slow release microparticles containing cytokines, which are directly injected into a tumor, in order to treat the tumor, e.g., cause tumor regression or to prevent tumor growth or metastasis.

Abstract: The invention relates to methods and products for preventing and treating tumors. In particular the invention relates to the use of slow release microparticles containing IL-12, which are directly injected into a tumor, in order to treat the tumor or to prevent tumor growth or metastasis.