Patents by Inventor Nello Mainolfi

Nello Mainolfi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STAT6 INHIBITORS AND USES THEREOF
    Publication number: 20250214977
    Abstract: The present invention provides compounds, compositions, and methods of using the same.
    Type: Application
    Filed: November 11, 2024
    Publication date: July 3, 2025
    Inventors: Huijun Dong, Bin Yang, Bruce C. Follows, Xiao Zhu, Matthew M. Weiss, Xiaozhang Zheng, Xin Huang, Lijing Su, Nello Mainolfi, Thijs Beuming, Xue Fei, Philip Collier, Yi Zhang, Christopher L. Carroll
  • STAT6 INHIBITORS AND USES THEREOF
    Publication number: 20250213586
    Abstract: The present invention provides compounds, compositions, and methods of using the same.
    Type: Application
    Filed: January 2, 2025
    Publication date: July 3, 2025
    Inventors: Huijun Dong, Bin Yang, Bruce C. Follows, Xiao Zhu, Matthew M. Weiss, Xiaozhang Zheng, Xin Huang, Lijing Su, Nello Mainolfi, Thijs Beuming, Xue Fei, Philip Collier, Yi Zhang
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20250163042
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: January 7, 2025
    Publication date: May 22, 2025
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
  • PROTEIN DEGRADERS AND USES THEREOF
    Publication number: 20250145636
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Application
    Filed: March 12, 2024
    Publication date: May 8, 2025
    Inventors: Nello MAINOLFI, Nan ji, Arthur F. Kluge
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20250121073
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 10, 2024
    Publication date: April 17, 2025
    Inventors: Nello Mainolfi, Nan Ji, Matthew M. Weiss, Xiaozhang Zheng, Yi Zhang, Paul R. Fleming, Xiao Zhu
  • 3-phosphoglycerate dehydrogenase inhibitors and uses thereof
    Patent number: 12264132
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: April 1, 2025
    Assignee: Raze Therapeutics, Inc.
    Inventor: Nello Mainolfi
  • IRAK degraders and uses thereof
    Patent number: 12258341
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: July 19, 2023
    Date of Patent: March 25, 2025
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
  • STAT DEGRADERS AND USES THEREOF
    Publication number: 20250059221
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 3, 2024
    Publication date: February 20, 2025
    Inventors: Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20250059164
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 23, 2024
    Publication date: February 20, 2025
    Inventors: Xiaozhang ZHENG, Nello Mainolfi, Matthew M. Weiss
  • CRBN LIGANDS AND USES THEREOF
    Publication number: 20250051320
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
    Type: Application
    Filed: February 21, 2024
    Publication date: February 13, 2025
    Inventors: Nello MAINOLFI, Nan JI, Arthur F. KLUGE
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20250011325
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: August 9, 2024
    Publication date: January 9, 2025
    Inventors: Nello Mainolfi, Christopher De Savi, Matthew M. Weiss, Xiao Zhu, Xiaozhang Zheng, Bruce C. Follows
  • Caffeine inhibitors of MTHFD2 and uses thereof
    Patent number: 12187728
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: January 7, 2025
    Assignee: Raze Therapeutics, Inc.
    Inventors: Nello Mainolfi, Mikel P. Moyer, Eddine Saiah, Cristina Lecci, Robert David Matthew Pace, Heather Tye, Julia Vile
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20250000985
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 20, 2024
    Publication date: January 2, 2025
    Inventors: Nello MAINOLFI, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
  • IRAK degraders and uses thereof
    Patent number: 12168057
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: April 24, 2023
    Date of Patent: December 17, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
  • IRAK degraders and uses thereof
    Patent number: 12150995
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: November 26, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Matthew M. Weiss, Xiaozhang Zheng, Yi Zhang, Paul R. Fleming, Xiao Zhu
  • IRAK degraders and uses thereof
    Patent number: 12091411
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: January 31, 2023
    Date of Patent: September 17, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Chris De Savi, Matthew M. Weiss, Xiao Zhu, Xiaozhang Zheng, Bruce C. Follows
  • STAT degraders and uses thereof
    Patent number: 12077555
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: May 4, 2022
    Date of Patent: September 3, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20240239777
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 19, 2023
    Publication date: July 18, 2024
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
  • Protein degraders and uses thereof
    Patent number: 12006329
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Grant
    Filed: August 18, 2022
    Date of Patent: June 11, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge
  • CRBN ligands and uses thereof
    Patent number: 11932635
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
    Type: Grant
    Filed: November 28, 2022
    Date of Patent: March 19, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge