Patents by Inventor Nelson B. Freimer
Nelson B. Freimer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040176572Abstract: The present invention relates to the mammalian HKNG1 gene, a gene associated with bipolar affective disorder (BAD) in humans. The invention relates, in particular, to methods for the diagnostic evaluation, genetic testing and prognosis of HKNG1 neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder.Type: ApplicationFiled: July 28, 2003Publication date: September 9, 2004Inventors: Nelson B. Freimer, Victor I. Reus, Susan K. Service, Lynne Allison McInnes, Hong Chen, Pedro Leon, Lodewijk A. Sandkuijl, L. Sandkuijl-Schakenbos
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Patent number: 6750010Abstract: The present invention is directed to methods of detecting the presence of a bipolar mood disorder susceptibility locus in an individual, comprising analyzing a sample of DNA for the presence of a DNA polymorphism on the short arm of chromosome 18 between the telomere and D18S481, wherein the DNA polymorphism is associated with a form of bipolar mood disorder. The invention for the first time provides strong evidence of a susceptibility gene for bipolar mood disorder that is located in the terminal 5 cM region of the short arm of chromosome 18. The disclosure describes the use of linkage analysis and genetic markers in this 5 cM region to fine map the region and the use of genetic markers to genetically diagnose (genotype) bipolar mood disorder in individuals, to confirm phenotypic diagnoses of bipolar mood disorder, to determine appropriate treatments for patients with particular genotypic subtypes.Type: GrantFiled: November 24, 1997Date of Patent: June 15, 2004Assignees: The Regents of the University of California, Univerisity of Costa RicaInventors: Nelson B. Freimer, Lodewijk Sandkuijl, Pedro Leon, Victor I. Reus, Michael Escamilla, Lynne Allison McInnes, Susan K. Service
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Publication number: 20030158398Abstract: The present invention relates of the mammalian HKNG1 gene, a gene associated with bipolar affective disorder (BAD) in humans. The invention relates, in particular, to methods for the diagnostic evaluation, genetic testing and prognosis of HKNG1 neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder.Type: ApplicationFiled: June 4, 2002Publication date: August 21, 2003Applicant: Millennium Pharmaceuticals, Inc., a Delaware corporationInventors: Hong Chen, Nelson B. Freimer
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Publication number: 20020142298Abstract: The present invention relates to the mammalian fsh22 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh22 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh22 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh22 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh22 and to using such compounds as therapeutic agents in the treatment of fsh22 disorders and neuropsychiatric disorders.Type: ApplicationFiled: December 20, 2000Publication date: October 3, 2002Applicant: The Regents of the University of CaliforniaInventors: Hong Chen, Nelson B. Freimer
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Patent number: 6399762Abstract: The present invention relates of the mammalian HKNG1 gene, a gene associated with bipolar affective disorder (BAD) in humans. The invention relates, in particular, to methods for the diagnostic evaluation, genetic testing and prognosis of HKNG1 neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder.Type: GrantFiled: September 7, 2000Date of Patent: June 4, 2002Assignees: The Regents of the University of California, Millennium Pharmaceuticals, Inc.Inventors: Hong Chen, Nelson B. Freimer
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Patent number: 6342351Abstract: The present invention relates of the mammalian HKNG1 gene, a gene associated with bipolar affective disorder (BAD) in humans. The invention relates, in particular, to methods for the diagnostic evaluation, genetic testing and prognosis of HKNG1 neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder.Type: GrantFiled: March 16, 1999Date of Patent: January 29, 2002Assignees: Millennium Pharmaceuticals, Inc., Regents of the University of CaliforniaInventors: Hong Chen, Nelson B. Freimer
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Patent number: 6323244Abstract: The present invention relates to the mammalian rTS gene, a gene associated with bipolar affective disorder (BAD) in humans. The invention relates to methods for the identification of compounds that modulate the expression of rTS and to using such compounds as therapeutic agents in the treatment of rTS disorders and neuropsychiatric disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of rTS neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder, and to methods and compositions for the treatment these disorders.Type: GrantFiled: November 5, 1997Date of Patent: November 27, 2001Assignees: Millennium Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Hong Chen, Nelson B. Freimer
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Patent number: 6248528Abstract: The present invention relates to the mammalian Hcen-2 gene. The invention relates to methods for the identification of compounds that modulate the expression of Hcen-2 and to using such compounds as therapeutic agents in the treatment of Hcen-2 disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of Hcen-2 mediated disorders, and to methods and compositions for the treatment these disorders. The invention also relates to use of the Hcen-2 gene and/or gene products as markers for fine structure mapping of a region of human chromosome 18, including a region of the chromosome involved in mediating neuropsychiatric disorders.Type: GrantFiled: April 2, 1999Date of Patent: June 19, 2001Assignees: Millennium Pharmaceuticals, Inc., Regents of the University of CaliforniaInventors: Hong Chen, Nelson B. Freimer
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Patent number: 6136532Abstract: The present invention is directed to methods of detecting the presence of a bipolar mood disorder susceptibility locus in an individual, comprising analyzing a sample of DNA for the presence of a DNA polymorphism on the long arm of chromosome 18 between markers D18S469 and D18S554, wherein the DNA polymorphism is associated with a form of bipolar mood disorder. The invention for the first time provides strong evidence of a susceptibility gene for bipolar mood disorder that is located in the 18q22-q23 region of the long arm of chromosome 18. The disclosure describes the use of linkage analysis and genetic markers in this 18q22-q23 region to fine map the region and the use of genetic markers to genetically diagnose (genotype) bipolar mood disorder in individuals, to confirm phenotypic diagnoses of bipolar mood disorder, to determine appropriate treatments for patients with particular genotypic subtypes.Type: GrantFiled: November 24, 1997Date of Patent: October 24, 2000Assignees: The Regents of the University of California, The University of Costa RicaInventors: Nelson B. Freimer, Lodewijk Sandkuijl, Pedro Leon, Victor I. Reus, Michael Escamilla, Lynne Allison McInnes
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Patent number: 5955355Abstract: The present invention relates to the mammalian fsh05 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh05 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh05 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh05 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh05 and to using such compounds as therapeutic agents in the treatment of fsh05 disorders and neuropsychiatric disorders.Type: GrantFiled: March 27, 1997Date of Patent: September 21, 1999Assignees: Millennium Pharmaceuticals, Inc., The Regents University of CaliforniaInventors: Hong Chen, Nelson B. Freimer
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Patent number: 5939316Abstract: The present invention relates to the mammalian fsh22 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh22 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh22 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh22 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh22 and to using such compounds as therapeutic agents in the treatment of fsh22 disorders and neuropsychiatric disorders.Type: GrantFiled: March 27, 1997Date of Patent: August 17, 1999Assignees: Millennium Pharmaceuticals, Inc., The Regents University of CaliforniaInventors: Hong Chen, Nelson B. Freimer
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Patent number: 5914394Abstract: The present invention relates to the mammalian fsh16 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh16 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh16 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh16 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh16 and to using such compounds as therapeutic agents in the treatment of fsh16 disorders and neuropsychiatric disorders.Type: GrantFiled: March 27, 1997Date of Patent: June 22, 1999Assignees: Millenium Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Hong Chen, Nelson B. Freimer
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Patent number: 5866412Abstract: The present invention relates to the mammalian fsh15w6 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh15w6 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh15w6 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh15w6 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh15w6 and to using such compounds as therapeutic agents in the treatment of fsh15w6 disorders and neuropsychiatric disorders.Type: GrantFiled: March 27, 1997Date of Patent: February 2, 1999Assignees: Millennium Pharmaceuticals, Inc., The Regents University of CaliforniaInventors: Hong Chen, Nelson B. Freimer