Patents by Inventor Nelson C. Yim

Nelson C. Yim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vasopressin compounds
    Patent number: 4749782
    Abstract: Certain vasopressin-like compounds whose structures have a .beta.,.beta.-diethyl-.beta.-mercaptopropionic acid at position 1 have unexpectedly potent V.sub.2 -antagonist activity. A species of the group is [1-.beta.,.beta.-diethyl-.beta.-mercaptopropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-8-arginine-9-desglycine]vasopressin.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: June 7, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: William F. Huffman, Michael L. Moore, Nelson C. Yim
  • Diuretic compositions and methods of producing diuresis
    Patent number: 4719199
    Abstract: 2- or 3-.beta.-Indolylalanyl and .beta.-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: January 12, 1988
    Assignee: Smithkline Beckman Corporation
    Inventor: Nelson C. Yim
  • Polypeptide intermediates
    Patent number: 4684716
    Abstract: 2- or 3-.beta.-Indolylalanyl and .beta.-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: August 4, 1987
    Assignee: SmithKline Beckman Corporation
    Inventor: Nelson C. Yim
  • Methods of producing vasodilation or antioxytocic activity
    Patent number: 4684621
    Abstract: Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V.sub.1 -vasopressin and oxytocin antagonist activity. A species of this series of new compounds is [1-desaminopenicillamine-2-(O-ethyl-D-tyrosine)-8-(1,4-diaminobutane)-9-de sglycinamide]-vasopressin.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: August 4, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Michael L. Moore, Nelson C. Yim
  • Polypeptide intermediates
    Patent number: 4658015
    Abstract: Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V.sub.1 -vasopressin and oxytocin antagonist activity. A species of this series of new compounds is [1-desaminopenicillamine-2-(O-ethyl-D-tyrosine)-8-(1,4-diaminobutane)-9-de sglycinamide]-vasopressin.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: April 14, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Michael L. Moore, Nelson C. Yim
  • Aromatic basic-tailed vasopressin antagonists
    Patent number: 4624943
    Abstract: Certain new vasopressin-like peptides which have structures characterized by having a bisaminoalkylbenzene present in the vasopressin tail at the 7- or 8-position retain vasopressin antagonist activity. A species of the invention is [1-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-8-1',4'-bis(aminomethyl)benzene-9-de sglycinamide]-vasopressin.
    Type: Grant
    Filed: March 20, 1985
    Date of Patent: November 25, 1986
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, Michael L. Moore, Nelson C. Yim
  • Basic V.sub.1 -vasopressin antagonists
    Patent number: 4604378
    Abstract: Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V.sub.1 -vasopressin and oxytocin antagonist activity. A species of this series of new compounds is [1-desaminopenicillamine-2-(O-ethyl-D-tyrosine)-8-(1,4-diaminobutane)-9-de sglycinamide]-vasopressin.
    Type: Grant
    Filed: November 21, 1984
    Date of Patent: August 5, 1986
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Michael L. Moore, Nelson C. Yim
  • .beta.-indolylalanyl or .beta.-indolylglycinyl vasopressin antagonists
    Patent number: 4597901
    Abstract: 2- or 3-.beta.-Indolylalanyl and .beta.-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: July 1, 1986
    Assignee: SmithKline Beckman Corporation
    Inventor: Nelson C. Yim
  • Basic heptapeptide vasopressin antagonists
    Patent number: 4543349
    Abstract: Certain cyclic vasopressin-like peptides, which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have vasopressin antagonist activity. A species of this series of new compounds is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-8-(1,5-diaminopentane)-8-desarginine -9-desglycinamide]-vasopressin.
    Type: Grant
    Filed: August 28, 1984
    Date of Patent: September 24, 1985
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, Michael L. Moore, Nelson C. Yim
  • Method for preparing lower alkyl .beta.-(S-benzylmercapto)-.beta.,.beta.-pentamethylenepropionates
    Patent number: 4299969
    Abstract: Lower alkyl .beta.-(S-benzylmercapto)-.beta.,.beta.-pentamethylenepropionates are prepared in improved yields by reacting lower alkyl cyclohexylideneacetates with benzylmercaptan in the presence of an alkali metal mercaptide.
    Type: Grant
    Filed: August 8, 1980
    Date of Patent: November 10, 1981
    Assignee: SmithKline Corporation
    Inventors: William F. Huffman, Nelson C. Yim
  • Substituted furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds and pharmaceutical use
    Patent number: 4187314
    Abstract: A group of 7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines with structures containing a furyl ring at position 1 which have dopaminergic activity. Particular species of this group include 7,8-dihydroxy-1-(furyl)-2,3,4,5-tetrahydro-1H-3-benzazepine and its dimethyl ether derivative.
    Type: Grant
    Filed: May 24, 1978
    Date of Patent: February 5, 1980
    Assignee: SmithKline Corporation
    Inventors: Kenneth G. Holden, Nelson C. Yim