Abstract: Systems and methods are provided to produce electromechanical interconnections within integrated circuits (ICs), printed circuit boards (PCBs) and between PCBs and other electronic components such as resistors, capacitors and integrated circuits. Elements include so-called “smart pins” or “neuro-pins” that facilitate electrical pathways in the dimension normal to the plane of a PCB. Smart pins or neuro-pins may be inserted using automated processes that do not require the high temperatures normally associated with soldering. Resultant circuits generally contain a large number of layers that are more compact and more readily constructed compared with conventional PCB-based circuitry.

Abstract: Systems and methods are provided to measure reaction times and/or responses for head, eye, eyelid movements, and/or changes in pupil geometry. The system includes eyewear or headwear including one or more eye-tracking cameras for monitoring the position and geometry of at least one eye and its components of the user, one or more scene cameras for monitoring the user's surroundings, and one or more processors to determine reaction times. Optionally, the system may include one or more of a multi-axis accelerometer to monitor head movements, light sources to trigger visual evoked responses, and/or electronic inputs that may be used to indicate the time of occurrence of external reference events. Measured reaction times and other measurements may be monitored for use in a range of applications. Responses and reaction times may be measured continuously over extended periods, even over a lifetime to measure consequences of the aging process.

Abstract: An electronic system tracks a user's gaze to rapidly transport a cursor to a location within a focal region of the user's eye. The electronic system transports the cursor from an initial location across one or more displays to a new location in response to detecting one or more saccadic and/or vergence movements of the user's eye or in response to a signal indicating that the user desires to move the cursor to a new location within a focal region of the user's eye or eyes. In some embodiments, the electronic system moves the cursor to the new location along a trajectory wherein the cursor is visible along at least a portion of the trajectory, enabling the user to find the cursor more easily.

Abstract: An electronic system generates at a display virtual writing corresponding to tracked motion of the tip of a pointer with respect to a surface based on proximity of the tip of the pointer to the surface and the gaze of a user's eye. The electronic system determines the location and motion of the tip of the pointer with respect to the surface based on images captured by scene cameras, and determines the focus and gaze direction of the user's eye based on images captured by a user-facing camera. By generating virtual writing at the display corresponding to tracked motion of the tip of the pointer based on proximity of the tip of the pointer to the surface and based on the focus and gaze direction of the user's eye, the electronic system can enable virtual writing and associated collaboration services without the need for a specialized writing surface or pointer.

Abstract: Systems and methods are provided to produce electromechanical interconnections within integrated circuits (ICs), printed circuit boards (PCBs) and between PCBs and other electronic components such as resistors, capacitors and integrated circuits. Elements include so-called “smart pins” or “neuro-pins” that facilitate electrical pathways in the dimension normal to the plane of a PCB. Smart pins or neuro-pins may be inserted using automated processes that do not require the high temperatures normally associated with soldering. Resultant circuits generally contain a large number of layers that are more compact and more readily constructed compared with conventional PCB-based circuitry.

Abstract: An electronic system tracks a user's gaze to rapidly transport a cursor to a location within a focal region of the user's eye. The electronic system transports the cursor from an initial location across one or more displays to a new location in response to detecting one or more saccadic and/or vergence movements of the user's eye or in response to a signal indicating that the user desires to move the cursor to a new location within a focal region of the user's eye or eyes. In some embodiments, the electronic system moves the cursor to the new location along a trajectory wherein the cursor is visible along at least a portion of the trajectory, enabling the user to find the cursor more easily.

Abstract: A system mounted within eyewear or headwear to unobtrusively produce and track reference locations on the surface of one or both eyes of an observer is provided to improve the accuracy of gaze tracking. The system utilizes multiple illumination sources and/or multiple cameras to generate and observe glints from multiple directions. The use of multiple illumination sources and cameras can compensate for the complex, three-dimensional geometry of the head and the significant anatomical variations of the head and eye region that occurs among individuals. The system continuously tracks the initial placement and any slippage of eyewear or headwear. In addition, the use of multiple illumination sources and cameras can maintain high-precision, dynamic eye tracking as an eye moves through its full physiological range.

Abstract: Devices and methods are provided for eye-tracking, e.g., including a freeform optical assembly and/or a modular design. In an exemplary embodiment, a device and method are provided that includes a wearable device on a user's head, the wearable device including a scene camera oriented to capture images of the user's surroundings. The user may perform a predetermined action with the user's eye to activate a photo feature of the wearable device, gaze at a region within the user's surroundings, the wearable device determining a focal point and limited field-of-view for the camera imaging field based on the center point, and activate the camera to capture an image of the limited field-of-view centered around the focal point.

Abstract: Systems and methods are provided to measure reaction times and/or responses for head, eye, eyelid movements, and/or changes in pupil geometry. The system includes eyewear or headwear including one or more eye-tracking cameras for monitoring the position and geometry of at least one eye and its components of the user, one or more scene cameras for monitoring the user's surroundings, and one or more processors to determine reaction times. Optionally, the system may include one or more of a multi-axis accelerometer to monitor head movements, light sources to trigger visual evoked responses, and/or electronic inputs that may be used to indicate the time of occurrence of external reference events. Measured reaction times and other measurements may be monitored for use in a range of applications. Responses and reaction times may be measured continuously over extended periods, even over a lifetime to measure consequences of the aging process.

Abstract: Systems and methods are provided to measure reaction times and/or responses for head, eye, eyelid movements, and/or changes in pupil geometry. The system includes eyewear or headwear including one or more eye-tracking cameras for monitoring the position and geometry of at least one eye and its components of the user, one or more scene cameras for monitoring the user's surroundings, and one or more processors to determine reaction times. Optionally, the system may include one or more of a multi-axis accelerometer to monitor head movements, light sources to trigger visual evoked responses, and/or electronic inputs that may be used to indicate the time of occurrence of external reference events. Measured reaction times and other measurements may be monitored for use in a range of applications. Responses and reaction times may be measured continuously over extended periods, even over a lifetime to measure consequences of the aging process.

Abstract: An electronic system generates at a display virtual writing corresponding to tracked motion of the tip of a pointer with respect to a surface based on proximity of the tip of the pointer to the surface and the gaze of a user's eye. The electronic system determines the location and motion of the tip of the pointer with respect to the surface based on images captured by scene cameras, and determines the focus and gaze direction of the user's eye based on images captured by a user-facing camera. By generating virtual writing at the display corresponding to tracked motion of the tip of the pointer based on proximity of the tip of the pointer to the surface and based on the focus and gaze direction of the user's eye, the electronic system can enable virtual writing and associated collaboration services without the need for a specialized writing surface or pointer.

Abstract: A system mounted within eyewear or headwear to unobtrusively produce and track reference locations on the surface of one or both eyes of an observer is provided to improve the accuracy of gaze tracking. The system utilizes multiple illumination sources and/or multiple cameras to generate and observe glints from multiple directions. The use of multiple illumination sources and cameras can compensate for the complex, three-dimensional geometry of the head and the significant anatomical variations of the head and eye region that occurs among individuals. The system continuously tracks the initial placement and any slippage of eyewear or headwear. In addition, the use of multiple illumination sources and cameras can maintain high-precision, dynamic eye tracking as an eye moves through its full physiological range.

Abstract: A system is provided for identifying reference locations within the environment of a device wearer. The system includes a scene camera mounted on eyewear or headwear coupled to a processing unit. The system may recognize objects with known geometries that occur naturally within the wearer's environment or objects that have been intentionally placed at known locations within the wearer's environment. One or more light sources may be mounted on the headwear that illuminate reflective surfaces at selected times and wavelengths to help identify scene reference locations and glints projected from known locations onto the surface of the eye. The processing unit may control light sources to adjust illumination levels in order to help identify reference locations within the environment and corresponding glints on the surface of the eye. Objects may be identified substantially continuously within video images from scene cameras to provide a continuous data stream of reference locations.

Abstract: A system mounted within eyewear or headwear to unobtrusively produce and track reference locations on the surface of one or both eyes of an observer is provided to improve the accuracy of gaze tracking. The system utilizes multiple illumination sources and/or multiple cameras to generate and observe glints from multiple directions. The use of multiple illumination sources and cameras can compensate for the complex, three-dimensional geometry of the head and the significant anatomical variations of the head and eye region that occurs among individuals. The system continuously tracks the initial placement and any slippage of eyewear or headwear. In addition, the use of multiple illumination sources and cameras can maintain high-precision, dynamic eye tracking as an eye moves through its full physiological range.

Abstract: Systems and methods are provided to measure reaction times and/or responses for head, eye, eyelid movements, and/or changes in pupil geometry. The system includes eyewear or headwear including one or more eye-tracking cameras for monitoring the position and geometry of at least one eye and its components of the user, one or more scene cameras for monitoring the user's surroundings, and one or more processors to determine reaction times. Optionally, the system may include one or more of a multi-axis accelerometer to monitor head movements, light sources to trigger visual evoked responses, and/or electronic inputs that may be used to indicate the time of occurrence of external reference events. Measured reaction times and other measurements may be monitored for use in a range of applications. Responses and reaction times may be measured continuously over extended periods, even over a lifetime to measure consequences of the aging process.

Abstract: A system mounted within eyewear or headwear to unobtrusively produce and track reference locations on the surface of one or both eyes of an observer is provided to improve the accuracy of gaze tracking. The system utilizes multiple illumination sources and/or multiple cameras to generate and observe glints from multiple directions. The use of multiple illumination sources and cameras can compensate for the complex, three-dimensional geometry of the head and the significant anatomical variations of the head and eye region that occurs among individuals. The system continuously tracks the initial placement and any slippage of eyewear or headwear. In addition, the use of multiple illumination sources and cameras can maintain high-precision, dynamic eye tracking as an eye moves through its full physiological range.

Abstract: A scene illumination system is provided that produces spatially uniform or controlled brightness levels for machine vision applications. The system includes a camera, multiple light sources that preferentially illuminate different regions within the camera's field-of-view, and a processing unit coupled to the camera and light sources. Focal regions of the light sources within the camera's field-of-view are sampled to determine average regional brightness and compared to target brightness levels. The processing unit controls the light sources to increase or decrease illumination levels to converge toward the target brightness levels within the field-of-view. This modulation of the light sources may be repeated with successive video images until target brightness levels are achieved.

Abstract: A system is provided for identifying reference locations within the environment of a device wearer. The system includes a scene camera mounted on eyewear or headwear coupled to a processing unit. The system may recognize objects with known geometries that occur naturally within the wearer's environment or objects that have been intentionally placed at known locations within the wearer's environment. One or more light sources may be mounted on the headwear that illuminate reflective surfaces at selected times and wavelengths to help identify scene reference locations and glints projected from known locations onto the surface of the eye. The processing unit may control light sources to adjust illumination levels in order to help identify reference locations within the environment and corresponding glints on the surface of the eye. Objects may be identified substantially continuously within video images from scene cameras to provide a continuous data stream of reference locations.

Abstract: A system is mounted within eyewear or headwear to unobtrusively produce and track reference locations on the surface of one or both eyes of an observer. The system utilizes multiple illumination sources and/or multiple cameras to generate and observe glints from multiple directions. The use of multiple illumination sources and cameras can compensate for the complex, three-dimensional geometry of the head and anatomical variations of the head and eye region that occurs among individuals. The system continuously tracks the initial placement and any slippage of eyewear or headwear. In addition, the use of multiple illumination sources and cameras can maintain high-precision, dynamic eye tracking as an eye moves through its full physiological range. Furthermore, illumination sources placed in the normal line-of-sight of the device wearer increase the accuracy of gaze tracking by producing reference vectors that are close to the visual axis of the device wearer.

Abstract: The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.