Abstract: The present disclosure relates to the field of tyrosine kinase enzyme inhibition, in particular anaplastic lymphoma kinase (ALK) inhibition using novel small molecules. Provided are compounds capable to modulate ALK activity, compositions that comprise the compounds, and methods of using the compounds for the treatment or prevention of diseases or conditions that are characterized by ALK activity or expression.

Abstract: Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.

Abstract: Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.

Abstract: The present disclosure relates to the field of tyrosine kinase enzyme inhibition, in particular anaplastic lymphoma kinase (ALK) inhibition using novel small molecules. Provided are compounds capable to modulate ALK activity, compositions that comprise the compounds, and methods of using the compounds for the treatment or prevention of diseases or conditions that are characterized by ALK activity or expression.

Abstract: Said process used to obtain, in industrial scale, wet sheets and membranes of bacterial cellulose of high purity and specific physical and chemical properties, using the appropriate culture medium that is prepared in a mechanical mixer furnished with a jacket for temperature control and heat exchange, using selected recycled or non-recycled inoculums, fermentation in covered trays with the temperature controlled by an external heating/cooling jacket through the circulation of hot/cold water, not requiring control of humidity and air renovation, collecting of the wet sheets that are then submitted to a process of purification and whitening by successive whirlpool washing and rinsing cycles using diverse heated or non-heated aqueous solutions, being afterwards forwarded to draining and drying/dehydration, passing through a semi-continuous system of rollers and belt conveyors made of absorbent material. This invention also refers to the process used to obtain compounded cellulosic wet sheets.