Patents by Inventor Nenghua Guo

Nenghua Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heparin and sulfatide binding peptides from the type-I repeats of human thrombospondin and conjugates thereof
    Patent number: 6051549
    Abstract: This invention identifies a biologically active group of peptide sequences from Type I repeat units of the extracellular matrix protein, human thrombospondin-1, identical or homologous to the sequence, KRFKQDGGWSHWSPWSSC (SEQ ID NO.30). The biological activities residing with the full sequences, portions thereof, and variants of the full or partial sequences are disclosed. The invention describes how biological activity may be enhanced by covalently linking these peptides to suitable carriers, preferably a branched, water-soluble polymer of low (or absent) toxicity and immunogenicity, such as polysucrose (Ficoll.TM.). The invention describes (1) a method for preparing such conjugates, (2) the use of the defined peptides or their conjugates in blocking or modifying the action on cellular processes of heparin (e.g.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: April 18, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David D. Roberts, Henry C. Krutzsch, Nenghua Guo
  • Heparin- and sulfatide binding peptides from the type I repeats of human thrombospondin and conjugates thereof
    Patent number: 5770563
    Abstract: This invention identifies a biologically active group of peptide sequences from Type I repeat units of the extracellular matrix protein, human thrombospondin-1, identical or homologous to the sequence, KRFKQDGGWSHWSPWSSC (SEQ ID NO:30). The biological activities residing with the full sequences, portions thereof, and variants of the full or partial sequences are disclosed. The invention describes how biological activity may be enhanced by covalently linking these peptides to suitable carriers, preferably a branched, water-soluble polymer of low (or absent) toxicity and immunogenicity, such as polysucrose (Ficoll.TM.). The invention describes (1) a method for preparing such conjugates, (2) the use of the defined peptides or their conjugates in blocking or modifying the action on cellular processes of heparin (e.g.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 23, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David D. Roberts, Philip J. Browning, Joseph L. Bryant, John K. Inman, Henry C. Krutzsch, Nenghua Guo
  • Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin
    Patent number: 5357041
    Abstract: The present invention relates to peptides from the three type I repeats of human endothelial cell thrombospondin, which bind to sulfated glycoconjugates including heparin and sulfatide. Such peptides are useful in glycoconjugate binding pharmaceutical compositions and in a method for binding glycoconjugates in a subject.
    Type: Grant
    Filed: December 6, 1991
    Date of Patent: October 18, 1994
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: David D. Roberts, Nenghua Guo, Henry C. Krutzsch