Abstract: A sample inspection device includes a filter unit having a plurality of optical filters configured to transmit lights of different wavelength ranges, a light source unit configured to irradiate light to any one of the optical filters, a stage for placing a sample, and a reflector oriented to reflect light transmitted through one of the optical filters to the stage and to reflect light emitted from the sample on the stage to another one of the optical filters. The device also includes a detection unit for detecting light emitted from the sample on the stage through light transmitted through the another one of the optical filters, an actuator for moving the filter unit, and a control unit configured to control the actuator to move the filter unit when the detection unit receives the light passing through the another one of the optical filters.

Abstract: Provided herein is a pipette tip for electroporation including an outer surface, a void located within the outer surface, and a conductor located at least partially on or within the outer surface, in electrical communication with at least a portion of the outer surface and the void. Further provided herein is a pipette tip for electroporation including a body, a connector, and an elongated part. The connector is located at the distal end of the body and further includes at least one connecting post, a connecting part in mechanical communication with the connector, and a conductor located at least partially on or within the connector, wherein the conductor surrounds at least a portion of the connecting post. The elongated part also has a void and is located at the distal end of the connector. The void of the body, connector, and elongated part are in fluid communication.

Abstract: An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically, electroporation is carried out by applying electric pulses through a couple of electrodes from both end parts of the elongated hollow member, after the hollow member is charged with fluid specimen including cells and material which would be injected into the cells.

Abstract: A sample detection device includes a first polarizer configured to allow part of incident light to pass therethrough by polarizing the incident light, a stage disposed on a path of light having passed the first polarizer, the stage allowing a sample to be seated thereon, a second polarizer configured to polarize light and a detection unit configured to detect light having passed the second polarizer and to generate a detection signal. The first polarizer allows first polarized light oscillating in a first direction to proceed toward the sample when the incident light reaches the first polarizer. Emission light is emitted by an excitation of the sample when the first polarized light reaches the sample. The second polarizer allows second polarized light oscillating in a second direction to proceed toward the detection unit when the emission light reaches the second polarizer.

Abstract: An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically, electroporation is carried out by applying electric pulses through a couple of electrodes from both end parts of the elongated hollow member, after the hollow member is charged with fluid specimen including cells and material which would be injected into the cells.

Abstract: A sample detection device includes a first polarizer configured to allow part of incident light to pass therethrough by polarizing the incident light, a stage disposed on a path of light having passed the first polarizer, the stage allowing a sample to be seated thereon, a second polarizer configured to polarize light and a detection unit configured to detect light having passed the second polarizer and to generate a detection signal. The first polarizer allows first polarized light oscillating in a first direction to proceed toward the sample when the incident light reaches the first polarizer. Emission light is emitted by an excitation of the sample when the first polarized light reaches the sample. The second polarizer allows second polarized light oscillating in a second direction to proceed toward the detection unit when the emission light reaches the second polarizer.

Abstract: Provided herein is a pipette tip for electroporation including an outer surface, a void located within the outer surface, and a conductor located at least partially on or within the outer surface, in electrical communication with at least a portion of the outer surface and the void. Further provided herein is a pipette tip for electroporation including a body, a connector, and an elongated part. The connector is located at the distal end of the body and further includes at least one connecting post, a connecting part in mechanical communication with the connector, and a conductor located at least partially on or within the connector, wherein the conductor surrounds at least a portion of the connecting post. The elongated part also has a void and is located at the distal end of the connector. The void of the body, connector, and elongated part are in fluid communication.

Abstract: Provided herein is a pipette tip for electroporation including an outer surface, a void located within the outer surface, and a conductor located at least partially on or within the outer surface, in electrical communication with at least a portion of the outer surface and the void. Further provided herein is a pipette tip for electroporation including a body, a connector, and an elongated part. The connector is located at the distal end of the body and further includes at least one connecting post, a connecting part in mechanical communication with the connector, and a conductor located at least partially on or within the connector, wherein the conductor surrounds at least a portion of the connecting post. The elongated part also has a void and is located at the distal end of the connector. The void of the body, connector, and elongated part are in fluid communication.

Abstract: An apparatus for clearing tissue using electrophoresis according to an embodiment of the present invention comprises: a chamber which can contain therein a buffer solution and the biological tissue and has an inlet port and an outlet port for circulating the buffer solution; a support member, located within the chamber, for supporting the biological tissue; and electrodes located within the chamber and formed separately of a first electrode and a second electrode which correspond to each other. With the apparatus, it is possible to minimize the degradation of decomposition efficiency and quickly clear the tissue compared to a conventional apparatus.

Abstract: An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically, electroporation is carried out by applying electric pulses through a couple of electrodes from both end parts of the elongated hollow member, after the hollow member is charged with fluid specimen including cells and material which would be injected into the cells.

Abstract: An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically, electroporation is carried out b applying electric pulses through a couple of electrodes from both end parts of the elongated hollow member, after the hollow member is charged with fluid specimen including cells and material which would be injected into the cells.

Abstract: The present invention is about biological tissue refractive index (RI) matching composition and the method for clearing biological tissue. Specifically, the RI matching composition of the present invention shows remarkable RI matching effects when clearing biological tissue, and has excellent fluorescent signal preservation, and can be used for long-term storage of biological tissue since the biological tissue remains clear during in low temperature storage.

Abstract: Provided herein is a pipette tip for electroporation including an outer surface, a void located within the outer surface, and a conductor located at least partially on or within the outer surface, in electrical communication with at least a portion of the outer surface and the void. Further provided herein is a pipette tip for electroporation including a body, a connector, and an elongated part. The connector is located at the distal end of the body and further includes at least one connecting post, a connecting part in mechanical communication with the connector, and a conductor located at least partially on or within the connector, wherein the conductor surrounds at least a portion of the connecting post. The elongated part also has a void and is located at the distal end of the connector. The void of the body, connector, and elongated part are in fluid communication.

Abstract: An apparatus for clearing tissue using electrophoresis according to an embodiment of the present invention comprises: a chamber which can contain therein a buffer solution and the biological tissue and has an inlet port and an outlet port for circulating the buffer solution; a support member, located within the chamber, for supporting the biological tissue; and electrodes located within the chamber and formed separately of a first electrode and a second electrode which correspond to each other. With the apparatus, it is possible to minimize the degradation of decomposition efficiency and quickly clear the tissue compared to a conventional apparatus.

Abstract: Provided herein is a pipette tip (600) for electroporation including an outer surface, a void (611) located within the outer surface, and a conductor (622) located at least partially on or within the outer surface, in electrical communication with at least a portion of the outer surface and the void. Further provided herein is a pipette tip for electroporation including a body, a connector (620), and an elongated part (630). The connector is located at the distal end of the body and further includes at least one connecting post, a connecting part in mechanical communication with the connector, and a conductor located at least partially on or within the connector, wherein the conductor surrounds at least a portion of the connecting post. The elongated part also has a void and is located at the distal end of the connector. The void of the body, connector, and elongated part are in fluid communication.

Abstract: An excitation light from a first light source is adapted to be irradiated to a subject without passing through an objective lens so that the first light source and the subject may be arranged to be adjacent to each other. As a result, an excitation light having a high intensity of radiation may be irradiated to the subject to obtain a strong fluorescence signal. In addition, since the optical path of the excitation light from the first light source and the optical path of the fluorescent emission light emitted from the first dichroic mirror and the white light do not coincide with each other, a high S/N ratio may be obtained.

Abstract: An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically, electroporation is carried out by applying electric pulses through a couple of electrodes from both end parts of the elongated hollow member, after the hollow member is charged with fluid specimen including cells and material which would be injected into the cells.

Abstract: An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically, electroporation is carried out by applying electric pulses through a couple of electrodes from both end parts of the elongated hollow member, after the hollow member is charged with fluid specimen including cells and material which would be injected into the cells.

Abstract: An excitation light from a first light source is adapted to be irradiated to a subject without passing through an objective lens so that the first light source and the subject may be arranged to be adjacent to each other. As a result, an excitation light having a high intensity of radiation may be irradiated to the subject to obtain a strong fluorescence signal. In addition, since the optical path of the excitation light from the first light source and the optical path of the fluorescent emission light emitted from the first dichroic mirror and the white light do not coincide with each other, a high S/N ratio may be obtained.

Abstract: Disclosed is a microchip. The microchip of the present invention is characterized by comprising: a first plate; and a second plate coupled to the first plate to form a channel, wherein the first plate comprises: a channel cover part; a first connection part spaced apart from the outer periphery of the channel cover part by a certain distance; and a tensile strength generation connecting part for mutually connecting the channel cover part and the first connection part so that the channel cover part elastically contacts the channel region formed on the second plate when the first plate is coupled to the second plate. According to the present invention, the channel cover part forming the channel elastically contacts the channel region formed on the second plate, thereby providing a microchip capable of providing a channel having a stable structure.