Abstract: A device for removing tissue particles from the tissue surface or an area close thereto is disclosed. The device comprises a head piece into which a nozzle tube extends with multiple nozzle openings that are oriented toward a head piece opening. Adjacent to the head piece opening the head piece comprises a contact surface for being placed on the tissue surface. Via a supply channel, pressurized liquid can be fed into the nozzle tube and ejected from the nozzle openings to form compact fluid jets to remove tissue particles when impacting on the tissue surface, which are then present in the head piece. The head piece interior space is fluidically connected with a suction channel to suck tissue particles out of the interior space and collect them in a particle collection device. Such a device can be used to gently remove a tissue sample in form of the tissue particles.