Patents by Inventor Nestor Annibali

Nestor Annibali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for obtaining aspart insulin using a yeast strain
    Patent number: 8691530
    Abstract: The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a Pichia pastoris yeast strain. In particular, the invention refers to a biotechnological process for obtaining aspart insulin.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: April 8, 2014
    Assignee: Laboratorios Beta S.A.
    Inventors: Nestor Annibali, Mercedes Goin, Graciela Trejo, Federico Carrizo, Diego Baruque, Analía Morales
  • PROCESS FOR OBTAINING ASPART INSULIN USING A PICHIA PASTORIS YEAST STRAIN
    Publication number: 20110117600
    Abstract: The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a Pichia pastoris yeast strain. In particular, the invention refers to a biotechnological process for obtaining aspart insulin.
    Type: Application
    Filed: July 15, 2010
    Publication date: May 19, 2011
    Applicant: LABORATORIOS BETA S.A.
    Inventors: Nestor Annibali, Mercedes Goin, Graciela Trejo, Federico Carrizo, Diego Baruque, Analía Morales
  • Expression of a human insulin precursor in
    Patent number: 7091032
    Abstract: Methylotrophic recombinant yeast strain producing human insulin precursor, the strain comprising, in its genome, a copy of a first DNA construction and a second DNA construction, wherein the constructions are capably of directing the expression and secretion of human insulin precursor of the formula B(1-30)-Y1-Y2-A(1-21), wherein Y1 is lysine or arginine; Y2 is lysine or arginine; B(1-30) is the B peptide of the human insulin; and B(1-21) is the A peptide of human insulin, and wherein the strain is yeast Pichia Pastoris. DNA constructions and method for obtaining the strain are also provided.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: August 15, 2006
    Assignee: Laboratorios Beta S.A.
    Inventor: Nestor Annibali
  • Expression of a human insulin precursor in P. pastoris
    Publication number: 20030104607
    Abstract: Methylotrophic recombinant yeast strain producing human insulin precursor, the strain comprising, in its genome, a copy of a first DNA construction and a second DNA construction, wherein the constructions are capably of directing the expression and secretion of human insulin precursor of the formula B(1-30)-Y1-Y2-A(1-21), wherein Y1 is lysine or arginine; Y2 is lysine or arginine; B(1-30) is the B peptide of the human insulin; and B(1-21) is the A peptide of human insulin, and wherein the strain is yeast Pichia Pastoris. DNA constructions and method for obtaining the strain are also provided.
    Type: Application
    Filed: September 12, 2001
    Publication date: June 5, 2003
    Inventor: Nestor Annibali