Patents by Inventor Nestor CHristophe, Francis, Robert BUYCK

Nestor CHristophe, Francis, Robert BUYCK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperazine derivatives for influenza virus inhibitions
    Patent number: 11040963
    Abstract: The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: June 22, 2021
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Maria Van Dongen, Jaroslaw Juraszek, Griet Wim Bert Schepens, Charles Edward Lawson, Brian Shook, Maria Tim Hugo Jonckers, Abdellah Tahri, Bernard Pierre Jean-Marie Raboisson, Nestor CHristophe Francis Robert Buyck
  • PIPERAZINE DERIVATIVES FOR INFLUENZA VIRUS INHIBITIONS
    Publication number: 20200010459
    Abstract: The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.
    Type: Application
    Filed: February 1, 2018
    Publication date: January 9, 2020
    Inventors: Maria VAN DONGEN, Jaroslaw JURASZEK, Griet Wim Bert SCHEPENS, Charles Edward LAWSON, Brian SHOOK, Maria Tim, Hugo JONCKERS, Abdellah TAHRI, Bernard Pierre, Jean-Marie RABOISSON, Nestor CHristophe, Francis, Robert BUYCK