Abstract: Device for the controlled administration of substances to be inserted in a body cavity, characterized by: an anchoring medium allowing for a firm anchorage of the device in said body cavity; at least one substance support medium for the release of at least one substance into the body cavity following a specific protocol and in which each substance to be administered comprises an independent protocol that establishes a release kinetics with one or more substance administration stages, being each stage defined by a different release kinetics. These devices are useful to develop a simple or complex treatment protocol in mammals. The formulations applicable to the substance support media as well as the appropriate manufacturing processes are also provided.

Abstract: Embodiments of the present invention generally relate to devices and processes related to estrus synchronization. Particular embodiments of devices and processes of the present invention slowly release progesterone over a period of time for estrus synchronization.