Abstract: The present invention relates to diagnostic platform. More specifically, the invention relates to a dual platform composed of a detection and quantification unit and a characterization unit, systems, kits, methods and uses thereof in detection, quantification and characterization of pathogens, the system comprising monoclonal-antibody-based biosensor chips, for detection and/or quantification of pathogens in a sample, and substrate-based biosensor chips for enzymatically profiling the pathogen in the sample.

Abstract: The present disclosure relates to a biosensor chip device usable for identifying and/or quantifying a target in a sample by electrochemical impedance spectroscopy (EIS) analysis. The biosensor chip device disclosed herein comprises a plurality of electrodes connectable to at least one electronic device, wherein, at least one of the electrodes is a working electrode connected directly or indirectly to at least one target binding site and/or moiety. It should be noted that the target binding site and/or moiety specifically binds the at least one target or any component thereof. Still further, in some embodiments, the plurality of electrodes is configured for electrochemical impedance spectroscopy (EIS) analysis of the sample. More specifically, the invention relates to monoclonal-antibody-based biosensor chip, devices, kits and diagnostic methods for detection of pathogens expressing Type III secretion system (T3SS) in a sample.

Abstract: The invention relates to human antibodies specific for Type III secretion system (T3SS), variants and biosimilars thereof. The human antibodies of the invention are specifically directed at the EspB protein. The preset disclosure further provides compositions and uses of the disclosed antibodies in treatment and diagnosis of MDR pathogenic bacterial infections.

Abstract: Peptides including an amino acid sequence of a fragment of mammalian Toll-like receptor-4 (TLR-4), analogs and derivatives thereof, and pharmaceutical compositions including these peptides. Methods for modulating a TLR-4 mediated immune response, particularly stimulating TLR-4 mediated immune response, thereby treating infectious diseases and cancer.

Abstract: Peptides including an amino acid sequence of a fragment of mammalian Toll-like receptor-4 (TLR-4), analogs and derivatives thereof, and pharmaceutical compositions including these peptides. Methods for modulating a TLR-4 mediated immune response, particularly stimulating TLR-4 mediated immune response, thereby treating infectious diseases and cancer.