Abstract: A prosthetic heart valve including a valve housing configured to be positioned adjacent to a heart valve annulus, one or more flaps moveably coupled to the valve housing, a passage defined by an inner surface of at least one of the valve housing and the one or more flaps, wherein the passage is configured to facilitate blood flow therethrough along a longitudinal axis thereof, from an inflow side to an outflow side of the valve, one or more openings through the inner surface located such that at an open position of the heart valve, a portion of the blood flow flowing along the longitudinal axis of the passage is redirected from the passage through the one or more openings, wherein the direction of the redirected blood flow has a component that is normal to the longitudinal axis of the passage, thereby mitigating stagnation of the blood flow and thus mitigating a risk of blood clots formation.

Abstract: Disclosed herein is a method for providing localized treatment at a target site in a blood vessel of a subject. The method includes (i) delivering to a vicinity of a target site in a blood vessel a water-immiscible fluid such as to displace blood from the vicinity of the target site, and (ii) administering an active agent to the target site, wherein the water-immiscible fluid and the active agent are mutually immiscible, or substantially mutually immiscible, so that the active agent is trapped by the water-immiscible fluid.

Abstract: The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders and internal hemorrhage.

Abstract: The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.

Abstract: The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders and internal hemorrhage.

Abstract: The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.