Abstract: A method for multiplexing measurements of related values using predetermined numbers of sources having intensities and subject to noise, and at least one sensor subject to saturation, said multiplexing comprising measuring each of said related values under a plurality of different combinations of said sources, the method comprises: generating a first set of multiplexing combinations; constraining said first set with respect to said saturation; modifying said first set with respect to said noise until an optimum is found between respective intensities and noise, and measuring said variables by multiplexing said sources according to said modified set.