Patents by Inventor Neva C. West

Neva C. West has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetracycline-regulated adeno-associated viral (AAV) vectors for gene delivery to the nervous system
    Patent number: 7811814
    Abstract: A vector and a method are provided for delivering a nucleic acid to a nervous system cell. The vector includes a first nucleic acid, a second nucleic acid, inverted terminal repeats of adeno-associated virus, and a tetracycline-off regulatable promoter system that includes a first promoter operably linked to the first nucleic acid and a second promoter operably linked to the second nucleic acid. The promoters drive expression in opposite directions and away from the inverted terminal repeats. The method includes providing a recombinant adeno-associated viral (rAAV) vector and administering the vector to a nervous system cell. Expression of a product from the first nucleic acid is regulatable by the promoter system.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: October 12, 2010
    Assignee: Children's Memorial Hospital
    Inventors: Martha C. Bohn, Lixin Jiang, Neva C. West, Elio F. Vanin
  • Tetracycline-Regulated Adeno-Associated Viral (AAV) Vectors for Gene Delivery to the Nervous System
    Publication number: 20090149409
    Abstract: A vector and a method are provided for delivering a nucleic acid to a nervous system cell. The vector includes a first nucleic acid, a second nucleic acid, inverted terminal repeats of adeno-associated virus, and a tetracycline-off regulatable promoter system that includes a first promoter operably linked to the first nucleic acid and a second promoter operably linked to the second nucleic acid. The promoters drive expression in opposite directions and away from the inverted terminal repeats. The method includes providing a recombinant adeno-associated viral (rAAV) vector and administering the vector to a nervous system cell. Expression of a product from the first nucleic acid is regulatable by the promoter system.
    Type: Application
    Filed: September 16, 2008
    Publication date: June 11, 2009
    Inventors: Martha C. Bohn, Lixin Jiang, Neva C. West, Elio F. Vanin
  • Tetracycline-regulated adeno-associated viral (AAV) vectors for gene delivery to the nervous system
    Patent number: 7456015
    Abstract: A vector and a method are provided for delivering a nucleic acid to a nervous system cell. The vector includes a first nucleic acid, a second nucleic acid, inverted terminal repeats of adeno-associated virus, and a tetracycline-off regulatable promoter system that includes a first promoter operably linked to the first nucleic acid and a second promoter operably linked to the second nucleic acid. The promoters drive expression in opposite directions and away from the inverted terminal repeats. The method includes providing a recombinant adeno-associated viral (rAAV) vector and administering the vector to a nervous system cell. Expression of a product from the first nucleic acid is regulatable by the promoter system.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: November 25, 2008
    Assignee: Children's Memorial Hospital
    Inventors: Martha C. Bohn, Lixin Jiang, Neva C. West, Elio F. Vanin