Abstract: N-Biphenyl(substituted methyl) aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

Abstract: The application of images comprising self-adhesive stickers to other images depicting a human head is facilitated by a novel calibration device. The device is placed over, for example, a photograph appearing in a magazine and categorizes a depicted head in terms of size and attitude (i.e. the extent to which the head may be turned to left or right). The applied images are adapted to co-operate with those parts of the target image not obscured so as to form a dimensionally appropriate composite image. A selection of images identical in shape but differing in size and attributable attitude may be provided from which a user may choose. Other embodiments comprise images dedicated to a specific target image produced and disseminated independently of the applied image, a system of cross-referencing and a device applying coordinates being provided. Means are disclosed whereby an image may overlay a target image without adhering to it.