Abstract: Compositions for the treatment and/or prevention of IgE-mediated disorders in a mammal by means of RNA interference are provided, together with methods for the use of such compounds. The inventive compositions comprise a binding agent that specifically binds to a target internalizable antigen that is expressed on the surface of a target cell of interest and a genetic construct that is capable of expressing a small interfering nucleic acid molecule (siNA) that suppresses expression of a target gene within the target cell, whereby, after binding to the target antigen, the binding agent and genetic construct are internalized into the cell, and the genetic construct released.

Abstract: Methods for the prevention and treatment of disorders, including disorders of the skin and respiratory system, such as infection with mycobacteria such as M. tuberculosis or M. avium, sarcoidosis, asthma, allergic rhinitis, allergic dermatitis and lung cancers are provided, such methods comprising administering a composition comprising at least one derivative of delipidated and deglycolipidated M. vaccae cells.

Abstract: Isolated polynucleotides and polypeptides derived from mammalian fsn -/-lymph node stromal cells are provided, together with expression vectors and host cells comprising such isolated polynucleotides. Methods for the use of such polynucleotides and polypeptides are also provided.

Abstract: Methods for the prevention and treatment of disorders, including disorders of the skin and respiratory system, such as infection with mycobacteria such as M. tuberculosis or M. avium, sarcoidosis, asthma, allergic rhinitis, allergic dermatitis and lung cancers are provided, such methods comprising administering a composition comprising at least one derivative of delipidated and deglycolipidated M. vaccae cells.

Abstract: Methods and compositions for the modification of immune response by modulating of the Notch signaling pathway are provided, together with methods for the treatment of disorders characterized by the presence of an unwanted immune response. Such compositions comprise components derived from Mycobacteria, such as Mycobacterium vaccae.

Abstract: Isolated fibroblast growth factor receptor polypeptides and polynucleotides encoding such polypeptides are provided, together with expression vectors and host cells comprising such isolated polynucleotides. Methods for the use of such polypeptides and polynucleotides are also provided.

Abstract: Isolated polynucleotides and polypeptides derived from mammalian fsn -/-lymph node stromal cells are provided, together with expression vectors and host cells comprising such isolated polynucleotides. Methods for the use of such polynucleotides and polypeptides are also provided.

Abstract: Isolated polynucleotides encoding polypeptides expressed in mammalian fsn -/- lymph node stromal cells are provided, together with expression vectors and host cells comprising such isolated polynucleotides. In certain embodiments such polynucleotides encode members of the fibroblast growth factor receptor family. Methods for the use of such polynucleotides and polypeptides are also provided.