Abstract: The present disclosure relates to a method and kits for detecting or determining the presence or likelihood of hyperglycemia in a subject. More particularly, the present invention relates to methods and kits for detecting or determining the likelihood of hyperglycemia in a subject based on a set of biomarkers in a breath sample, the biomarkers comprise at least one of cymene, butanol and pentanol.

Abstract: The present application relates to methods of detecting the presence of a respiratory disease in a subject. The method comprising the step of detecting or measuring a concentration of two or more biomarkers selected from the group consisting of Water, Methanol, 1,3-Butadiene, Acetone, Isoprene, Isobutyronitrile, 3-Methylpyridine, Pentanoic Acid, m-Cresol or p-Cresol, N,N-Dimethylaniline, and n-Decane in a sample obtained from the subject. Other biomarkers may include Hydrogen Peroxide, Trimethylamine, Methacrolein, Butanal, Propanoic Acid, Butanol, Carbon Disulfide, Aniline, Furfural, Cycloheptene, 1-Octene, Benzoic Acid, 6-Methyl-5-Hepten-2-one, 1-Decene, Dodecane, ?-Damascenone, Sesquiterpene, and Tetradecanoic Acid. The methods include applying the concentrations to a decision tree or a logistic regression model.

Abstract: There is provided a multi-layered sheet mask comprising at least (a) a porous first layer having a first side and a second side, wherein the first side is opposite to the second side, and comprises a plurality of three-dimensional patterns extending therefrom; (b) a second layer attached to the second side of the porous first layer, the second layer comprising at least one pouch for receiving or containing at least one first active ingredient; a porous support structure; an air pouch that is sandwiched between the second side of the porous first layer and the porous support structure; and a plurality of microchannels that extend from the pouch and beyond the first side of the porous first layer when the air pouch is deflated; and (c) a third layer attached to the second layer for receiving or containing at least one second active ingredient.

Abstract: The present invention relates to a device for repair of a region within an ear via a natural orifice, the device comprising a body. The body comprises a first port for visibly identifying the region to be sealed, the region being inside the ear; and a second port through which a seal can be introduced into the ear through the device. The region comprises a perforation of a tympanic membrane of the ear and the device is a speculum. The present invention also relates to method for repairing a perforation in a tympanic membrane using the same device.