Abstract: Compound of formula I: wherein: A is selected from: (i) where RF1 is H or F; (ii) (iii) a N-containing C6 heteroaryl group; and B is where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected from H, Me, Cl, F OMe; X3 is either CH or N; X4 is either CRF3 or N, where RF3 is H or F; where only one or two of X1, X2, X3 and X4 may be N; and R4 is selected from I, optionally substituted phenyl, optionally substituted C5-6 heteroaryl; optionally substituted C1-6 alkyl and optionally substituted C1-6 alkoxy, which are useful in the treatment of a condition ameliorated by the inhibition of MOZ.

Abstract: Methods and systems for determining event probabilities and anomalous events are provided. In one implementation, a method includes: receiving source data, where the source data is configured as a plurality of events with associated timestamps; searching the source data, where the searching provides a search result including N events from the plurality of events, where N is an integer greater than one, where each event of the N events includes a plurality of field values, where at least one event of the N events can include one or more categorical field values and one or more numerical field values; and for an event of the N events, determining a probability of occurrence for each field value of the plurality of field values; and using probabilities determined for the plurality of field values, determining a probability of occurrence for the event.

Abstract: A method is provided for detecting a perturbation with respect to an initial state, of a device comprising at least one resonant mechanical element exhibiting a physical parameter sensitive to a perturbation such that the said perturbation modifies the resonance frequency of the said resonant mechanical element. A device is provided for detecting a perturbation by hysteretic cycle comprising at least one electromechanical resonator with nonlinear behaviour and means for actuation and for detection of the reception signal via a transducer so as to analyse the response signal implementing the method. A mass sensor and a mass spectrometer using the device are also provided.

Abstract: A composition for durable non-permanent shaping or durable retention of a non-permanent shape of least one keratinous fiber comprising: (a) at least one film forming agent; and (b) at least one saccharide type compound chosen from C3 to C5 monosaccharides, optionally substituted with at least one C1 to C22 carbon chain, and compounds comprising at least one C5 to C7 saccharide unit substituted with at least one amino group.

Abstract: A water pillow for coupling acoustic energy into tissue. The pillow is configured to conform to a transducer to facilitate coupling of ultrasound energy. The pillow includes a pouch that accommodates the transducer to enable a snug fit between the pillow and the transducer. The pillow includes a liquid inlet and outlet to facilitate liquid circulation for cooling, is biocompatible, has a low attenuation, is conformal to the shape of the transducer, facilitates use of an adjustable pressure to achieve various standoffs, includes an integral pouch to facilitate an interference fit to the transducer, facilitates water circulation for cooling, is sterilizable, and is disposable. Either the surface of the pillow adapted to conform to a tissue interface, or the surface of the pillow adapted to conform to the transducer, or both, can include pores configured to weep liquid to facilitate acoustic coupling of the pillow with the transducer and/or tissue.

Abstract: A composition for durable non-permanent shaping or durable retention of a non-permanent shape of least one keratinous fiber comprising: (a) at least one film forming agent; and (b) at least one saccharide type compound chosen from C3 to C5 monosaccharides, optionally substituted with at least one C1 to C22 carbon chain, and compounds comprising at least one C5 to C7 saccharide unit substituted with at least one amino group.

Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Abstract: A process for straightening or relaxing hair involving the steps of: (a) contacting the hair with the above-disclosed hair straightening/relaxing composition to form treated hair; (b) optionally, rinsing the hair straightening/relaxing composition from the treated hair, after it has been in contact with the hair for a period of less than 60 minutes; (c) optionally, contacting the treated hair with a non-volatile oil chosen from plant, animal, mineral and synthetic oils; and (d) smoothing the treated hair using a combination of heat and means for physically smoothing hair.

Abstract: A process for styling dyed hair fibers in a manner which inhibits subsequent color loss during shampooing involving contacting the dyed hair fibers with a composition containing: (a) at least one polyamine compound having at least two amino groups; (b) at least one anionic silicone; (c) at least one film-forming polymer; and (d) optionally, at least one surfactant, and wherein (a) is present in the composition in an amount sufficient to inhibit color loss during shampooing.

Abstract: A process for inhibiting dyed hair fibers from losing their color during shampooing involving contacting the dyed hair fibers with a composition containing: (a) at least one polyamine compound having at least two amino groups; (b) at least one anionic silicone; and (c) optionally, at least one surfactant, and wherein (a) is present in the composition in an amount sufficient to inhibit the dyed hair fibers from losing their color during shampooing.

Abstract: A composition, kit and process for dyeing hair fibers in a manner which inhibits color loss during subsequent shampooing involving contacting the hair fibers with a composition containing: (a) at least one polyamine having at least two amino groups; (b) at least one anionic silicone; and (c) at least one dye component chosen from a direct dye and an oxidation dye, and wherein the dyed hair fibers inhibit color loss resulting from subsequent shampooing of the dyed hair fibers.

Abstract: A process for inhibiting hair fibers from becoming frizzy, involving contacting the hair fibers with a composition containing: (a) at least one polyamine compound having at least two amino groups; (b) at least one anionic silicone; (c) optionally, at least one surfactant; and (d) optionally, at least one film-forming polymer, and wherein (a) is present in the composition in an amount sufficient to inhibit dyed hair fibers from losing their color, as well as inhibit hair fibers, in general, from appearing frizzy.

Abstract: The present invention is drawn to a carrier composition containing: (a) at least one phospholipid; (b) at least one nonionic surfactant; (c) at least one anionic silicone; and (d) at least one water-insoluble material, and wherein the composition, when combined with an aqueous phase, forms an aqueous delivery system which is both stable, and clear to slightly hazy/limpid in appearance.

Abstract: The present invention is drawn to a carrier composition containing: (a) at least one polyamine compound comprising at least two amino groups; (b) at least one nonionic surfactant; (c) at least one anionic silicone; and (d) at least one water-insoluble material, and wherein the composition, when combined with an aqueous phase, forms an aqueous delivery system which is both stable, and clear to slightly hazy/limpid in appearance.

Abstract: The present invention is drawn to a carrier composition containing: (a) at least one fatty quaternary amine compound; (b) at least one nonionic surfactant; (c) at least one anionic silicone; and (d) at least one water-insoluble material, and wherein the composition, when combined with an aqueous phase, forms an aqueous delivery system which is both stable, and clear to slightly hazy/limpid in appearance.

Abstract: The present invention is drawn to a carrier composition containing: (a) at least one fatty monoamine compound; (b) at least one nonionic surfactant; (c) at least one anionic silicone; and (d) at least one water-insoluble material, and wherein the composition, when combined with an aqueous phase, forms an aqueous delivery system which is both stable, and clear to slightly hazy/limpid in appearance.

Abstract: A composition for durable non-permanent shaping or durable retention of a non-permanent shape of least one keratinous fiber comprising: (a) at least one film forming agent; and (b) at least one saccharide type compound chosen from C3 to C5 monosaccharides, optionally substituted with at least one C1 to C22 carbon chain, and compounds comprising at least one C5 to C7 saccharide unit substituted with at least one amino group.

Abstract: A composition used for relaxing/straightening hair containing: (a) at least one hydroxide generator in an amount sufficient to relax/straighten keratin fibers; (b) at least one bioactive glass component; and (c) optionally, at least one complexing agent.

Abstract: Methods for preventing reversion of at least one relaxed keratinous fiber and for relaxing at least one keratinous fiber comprising applying compositions comprising at least one sugar chosen from C3 to C5 monosaccharides and heating at least one keratinous fiber.

Abstract: Compositions containing at least one organic phospholipid capable of forming bilayers in aqueous solution; at least one amphoteric surfactant; and at least one nonionic surfactant present in an amount by weight equal to or greater than the amount of the phospholipid; where the phospholipid and surfactants are present in a combined amount sufficient to allow at least one water-insoluble ingredient selected from waxes and unneutralized and partially neutralized water-insoluble polymers, resins, and latexes to be incorporated into an aqueous solution. A delivery system containing the composition and methods for styling hair and for treating keratinous substances are also disclosed.