Patents by Inventor Ngoc Nhi Le

Ngoc Nhi Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydrogel microspheres containing peptide ligands for growth factor regulation in blood products
    Patent number: 10183079
    Abstract: Vascular endothelial growth factor VEGF-sequestering hydrogel microspheres that have been prepared to selectively bind VEGF from blood products are disclosed herein. In one particular embodiment, the microspheres bind VEGF as part of an intra-operative process such that the growth factor can be removed from the blood products before the products are used in a clinical procedure.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: January 22, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David Belair, Ngoc Nhi Le, Michael W. Toepke, Nicholas Impellitteri, Connie Sue Chamberlain, William Leo Murphy
  • HYDROGEL MICROSPHERES CONTAINING PEPTIDE LIGANDS FOR GROWTH FACTOR REGULATION IN BLOOD PRODUCTS
    Publication number: 20170266318
    Abstract: Vascular endothelial growth factor VEGF-sequestering hydrogel microspheres that have been prepared to selectively bind VEGF from blood products are disclosed herein. In one particular embodiment, the microspheres bind VEGF as part of an intra-operative process such that the growth factor can be removed from the blood products before the products are used in a clinical procedure.
    Type: Application
    Filed: March 18, 2016
    Publication date: September 21, 2017
    Inventors: David Belair, Ngoc Nhi Le, Michael W. Toepke, Nicholas Impellitteri, Connie Sue Chamberlain, William Leo Murphy
  • HYDROGEL COMPOSITIONS FOR USE IN CELL EXPANSION AND DIFFERENTIATION
    Publication number: 20170246357
    Abstract: Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiation of various cells.
    Type: Application
    Filed: May 16, 2017
    Publication date: August 31, 2017
    Inventors: William L. Murphy, Matthew Brian Parlato, James A Molenda, Ngoc Nhi Le
  • Covalently-immobilized hydrogel arrays in multi-well plates
    Patent number: 9694338
    Abstract: Hydrogel arrays, methods for preparing hydrogel arrays and methods for screening cell-substrate interactions using the hydrogel arrays are disclosed. Advantageously, the hydrogel arrays include individual hydrogel posts that are completely isolatable, allowing for systematic and independent control of the chemical composition and physical dimensions of each hydrogel post.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: July 4, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: William Murphy, Ngoc Nhi Le
  • Hydrogel compositions for use in promoting tubulogenesis
    Patent number: 9688957
    Abstract: Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. In particularly suitable embodiments, the hydrogel compositions of the present disclosure may be used to promote tubulogenesis of endothelial cells.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: June 27, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: William L. Murphy, Ngoc Nhi Le, Michael P. Schwartz, Eric Huy Dang Nguyen, Stefan Zorn, Hamisha Ardalani, Matthew Zanotelli, Matthew Brian Parlato, David Gregory Belair, William T. Daly
  • Hydrogel compositions for use in cell expansion and differentiation
    Patent number: 9683213
    Abstract: Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiation of various cells.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: June 20, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: William L. Murphy, Matthew Brian Parlato, James A Molenda, Ngoc Nhi Le
  • COVALENTLY-IMMOBILIZED HYDROGEL ARRAYS IN MULTI-WELL PLATES
    Publication number: 20160175800
    Abstract: Hydrogel arrays, methods for preparing hydrogel arrays and methods for screening cell-substrate interactions using the hydrogel arrays are disclosed. Advantageously, the hydrogel arrays include individual hydrogel posts that are completely isolatable, allowing for systematic and independent control of the chemical composition and physical dimensions of each hydrogel post.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 23, 2016
    Inventors: William Murphy, Ngoc Nhi Le
  • HYDROGEL COMPOSITIONS FOR USE IN PROMOTING TUBULOGENESIS
    Publication number: 20150291929
    Abstract: Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. In particularly suitable embodiments, the hydrogel compositions of the present disclosure may be used to promote tubulogenesis of endothelial cells.
    Type: Application
    Filed: April 10, 2015
    Publication date: October 15, 2015
    Inventors: William L. Murphy, Ngoc Nhi Le, Michael P. Schwartz, Eric Huy Dang Nguyen, Stefan Zorn, Hamisha Ardalani, Matthew Zanotelli, Matthew Brian Parlato, David Gregory Belair, William T. Daly
  • HYDROGEL COMPOSITIONS FOR USE IN CELL EXPANSION AND DIFFERENTIATION
    Publication number: 20150291930
    Abstract: Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiation of various cells.
    Type: Application
    Filed: April 10, 2015
    Publication date: October 15, 2015
    Inventors: William L. Murphy, Matthew Brian Parlato, James A. Molenda, Ngoc Nhi Le