Abstract: The present invention provides a closed-loop control method for an electronic fuel injection piston-engine on an unmanned aircraft consisting of the following steps: determination of a set of control coefficients; preliminary determination of fuel injection flow; determination of the injection limit; determination of the actual injectable value; perform fuel injection; the opening of the air intake valve is controlled to ensure that the fuel-air ratio always remains within a specified range. The present invention also provides a method for modeling the operation of an engine at each operating range. In addition, the method of physically simulating the operating conditions according to the pressure ranges of the engine is also proposed. The simulation method to find the control coefficients corresponding to each operating model of the engine is presented, the fuel injection closed-loop control structure is built on a control simulation software.