Patents by Inventor Ngocdiep T. LE

Ngocdiep T. LE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition
    Patent number: 9399021
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: July 26, 2016
    Assignee: Novartis AG
    Inventors: Douglas J. DeMarini, Francisco Henriquez, Ngocdiep T. Le, Lihong Wang
  • Pharmaceutical composition
    Patent number: 9271941
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: March 1, 2016
    Assignee: Novartis AG
    Inventors: Douglas J. DeMarini, Francisco Henriquez, Ngocdiep T. Le, Lihong Wang
  • Pharmaceutical composition
    Patent number: 9155706
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2, 4, 7-trioxo-3, 4, 6, 7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: October 13, 2015
    Assignee: Novartis AG
    Inventors: Douglas J. DeMarini, Francisco Henriquez, Ngocdiep T. Le, Lihong Wang
  • Combination for the treatment of cancer
    Patent number: 8906879
    Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering 4-amino-1-(2-deoxy-2,2-difluoro-?-D-erythro-pentofuranosyl)pyrimidin-2(1H)-on 2?, 2?-difluoro-2?-deoxycytidine, or a pharmaceutically acceptable salt thereof, and N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethy; -2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: December 9, 2014
    Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
    Inventors: Douglas J. DeMarini, Ngocdiep T. Le
  • NOVEL PHARMACEUTICAL COMPOSITION
    Publication number: 20140154316
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Application
    Filed: December 11, 2013
    Publication date: June 5, 2014
    Applicant: GlaxoSmithKline Intellectual Property (No.2) Limited
    Inventors: Douglas J. DeMARINI, Francisco Henriquez, Ngocdiep T. Le, Lihong Wang
  • NOVEL PHARMACEUTICAL COMPOSITION
    Publication number: 20140099365
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Application
    Filed: December 11, 2013
    Publication date: April 10, 2014
    Applicant: GlaxoSmithKline Intellectual Property
    Inventors: Douglas J. DeMARINI, Francisco Henriquez, Ngocdiep T. Le, Lihong Wang
  • NOVEL PHARMACEUTICAL COMPOSITION
    Publication number: 20140037726
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Application
    Filed: October 2, 2013
    Publication date: February 6, 2014
    Applicant: GlaxoSmithKline LLC
    Inventors: Douglas J. DeMARINI, Francisco HENRIQUEZ, Ngocdiep T. LE, Lihong WANG
  • Pharmaceutical composition
    Patent number: 8580304
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: November 12, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Douglas J. DeMarini, Francisco Henriquez, Ngocdiep T. Le, Lihong Wang
  • NOVEL PHARMACEUTICAL COMPOSITION
    Publication number: 20130266649
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Application
    Filed: December 20, 2011
    Publication date: October 10, 2013
    Inventors: Douglas J. DeMarini, Ngocdiep T. Le, Francisco Henriquez, Lihong Wang
  • COMBINATION
    Publication number: 20130261075
    Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering 4-amino-1-(2-deoxy-2,2-difluoro-?-D-erythro-pentofuranosyl)pyrimidin-2(1H)-on 2?,2?-difluoro-2?-deoxycytidine, or a pharmaceutically acceptable salt thereof, and N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethy;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof.
    Type: Application
    Filed: December 20, 2011
    Publication date: October 3, 2013
    Inventors: Douglas J. DeMarini, Ngocdiep T. Le
  • Novel Pharmaceutical Composition
    Publication number: 20120183613
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Application
    Filed: December 20, 2011
    Publication date: July 19, 2012
    Inventors: Douglas J. DeMARINI, Francisco Henriquez, Ngocdiep T. LE, Lihong Wang