Patents by Inventor Nguan Soon Tan

Nguan Soon Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210324045
    Abstract: Disclosed herein is a polymeric material that includes a crosslinked polymer matrix formed from a non-mammalian collagen and a crosslinking agent and/or a crosslinked polymer matrix formed from a non-mammalian collagen that has undergone self-crosslinking, wherein the non-mammalian collagen is type I collagen. Also disclosed herein is a wound dressing that incorporates said material and methods of treatment of a wound with said polymeric material or said wound dressing.
    Type: Application
    Filed: April 16, 2021
    Publication date: October 21, 2021
    Inventors: Chor Yong TAY, Cigdem CIMENOGLU, Jun Kit WANG, Nguan Soon TAN, Swee Neo Cleo CHOONG
  • Publication number: 20210244846
    Abstract: Disclosed herein is a hydrogel that eradicates biofilm bacteria from wounds and accelerates diabetic wound healing. Also disclosed herein are methods of manufacture and use of said hydrogel.
    Type: Application
    Filed: February 4, 2021
    Publication date: August 12, 2021
    Inventors: Bee Eng Mary CHAN, Chun Kiat YEO, Nguan Soon TAN, Surendra Hittanahalli MAHADEVEGOWDA
  • Publication number: 20210053317
    Abstract: Disclosed herein is a composite superhydrophobic material comprising: a substrate layer comprising a set of positively or negatively charged functional groups; a metal nanoparticle coating on top of the substrate layer, comprising a set of negatively or positively charged functional groups; a metal layer on top of the metal nanoparticle coating; and a first superhydrophobic layer on top of the metal layer. Also disclosed herein is a method of making said material, and a method of predicting increased risk of spontaneous miscarriage using said material.
    Type: Application
    Filed: January 15, 2019
    Publication date: February 25, 2021
    Applicant: Nanyang Technological University
    Inventors: Xing Yi Ling, Yih Hong Lee, Nguan Soon Tan, Xuemei Han, Hiang Kwee Lee, Ya-Chuan Kao
  • Publication number: 20200085045
    Abstract: An antimicrobial polymer or hydrogel is provided. The antimicrobial polymer or hydrogel comprises a branched polyethylenimine (PEI) grafted with poly(ethylene glycol) methacrylate (PEGMA) of formula (I) or a branched polyethylenimine (PEI) grafted with poly(ethylene glycol) methacrylate (PEGMA) and decane of formula (II), wherein: m is an integer ranging from 1 to 20; n is an integer ranging from 1 to 20; in formula (I), the grafting ratio of PEI-PEGMA ranges from 1:1 to 1:20; and in formula (II), the grafting ratio of PEI-decane-PEGMA ranges from 1:1:1 to 1:20:20.
    Type: Application
    Filed: March 16, 2018
    Publication date: March 19, 2020
    Inventors: Bee Eng Mary CHAN, Chun Kiat YEO, Nguan Soon TAN, Peng LI, Zanru GUO, Mya Mya KHIN
  • Patent number: 10517075
    Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: December 24, 2019
    Assignee: Nanyang Technological University
    Inventors: Nguan Soon Tan, Han Chung Kelvin Chong
  • Patent number: 10160803
    Abstract: The invention relates to the C-terminal fragment of angiopoietin-related protein 4 [cAngptl4] as a diagnostic marker for viral and bacterial pneumonia; anti-angiopoietin-related protein 4 therapeutic antibodies, and the use of anti-angiopoietin-related protein 4 antibodies in the treatment of viral and bacterial pneumonia.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: December 25, 2018
    Assignees: National University of Singapore, Nanyang Technological University
    Inventors: Vincent Tak Kwong Chow, Nguan Soon Tan, Liang Li, Ming Jie Tan, Han Chung Kelvin Chong
  • Publication number: 20180319878
    Abstract: Vascular disruption induced by interactions between tumor-secreted permeability factors and adhesive proteins on endothelial cells facilitates metastasis. The role of tumor secreted angiopoietin-like 4 (cANG-PTL4) in vascular leakiness and metastasis is controversial due to the lack of understanding of how cANGPTL4 modulates vascular integrity. Here, we show that cANGPTL4 instigated the disruption of endothelial continuity by directly interacting with three novel binding partners, integrin ?5?1, VE-cadherin and claudin-5, in a temporally sequential manner, thus facilitating metastasis. We showed that cANGPTL4 binds and activates integrin ?5?1-mediated Rac1/PAK signaling to weaken cell-cell contacts. cANGPTL4 subsequently associated with and declustered VE-cadherin and claudin-5, leading to endothelial disruption. Interfacing with the formation of the cANGPTL4 complexes delayed vascular disruption.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 8, 2018
    Inventor: Nguan Soon Tan
  • Patent number: 10087447
    Abstract: The invention provides an antibody specific to the ANGPTL4 protein capable of neutralizing proliferation and methods of making and using the same. The antibody of the invention is further directed to the C terminal region of the protein and may be capable of neutralizing cell proliferation and treating cancer. The antibody may be monoclonal and/or humanized antibody.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: October 2, 2018
    Assignee: Nanyang Technologies University
    Inventors: Nguan Soon Tan, Han Chung Chong, Ming Jie Tan, Royston Huang
  • Publication number: 20180199327
    Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.
    Type: Application
    Filed: February 26, 2018
    Publication date: July 12, 2018
    Inventors: Nguan Soon Tan, Han Chung Kelvin Chong
  • Patent number: 9931371
    Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: April 3, 2018
    Assignee: Nanyang Technologies University
    Inventors: Nguan Soon Tan, Han Chung Kelvin Chong
  • Publication number: 20160053268
    Abstract: The invention provides an antibody specific to the ANGPTL4 protein capable of neutralizing proliferation and methods of making and using the same. The antibody of the invention is further directed to the C terminal region of the protein and may be capable of neutralizing cell proliferation and treating cancer. The antibody may be monoclonal and/or humanized antibody.
    Type: Application
    Filed: January 6, 2015
    Publication date: February 25, 2016
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Nguan Soon TAN, Han Chung CHONG, Ming Jie TAN, Royston HUANG
  • Publication number: 20150368331
    Abstract: The invention relates to the C-terminal fragment of angiopoietin-related protein 4 [cAngptl4] as a diagnostic marker for viral and bacterial pneumonia; anti-angiopoietin-related protein 4 therapeutic antibodies, and the use of anti-angiopoietin-related protein 4 antibodies in the treatment of viral and bacterial pneumonia.
    Type: Application
    Filed: January 23, 2014
    Publication date: December 24, 2015
    Applicants: Nanyang Technological University, National University of Singapore
    Inventors: Vincent Tak Kwong Chow, Nguan Soon Tan, Liang Li, Ming Jie Tan, Han Chung Kelvin Chong
  • Publication number: 20150196616
    Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.
    Type: Application
    Filed: July 3, 2013
    Publication date: July 16, 2015
    Inventors: Nguan Soon Tan, Han Chung Kelvin Chong
  • Publication number: 20140242084
    Abstract: Vascular disruption induced by interactions between tumor-secreted permeability factors and adhesive proteins on endothelial cells facilitates metastasis. The role of tumor secreted angiopoietin-like 4 (cANGPTL4) in vascular leakiness and metastasis is controversial due to the lack of understanding of how cANGPTL4 modulates vascular integrity. Here, we show that cANGPTL4 instigated the disruption of endothelial continuity by directly interacting with three novel binding partners, integrin ?5?1, VEcadherin and claudin-5, in a temporally sequential manner, thus facilitating metastasis. We showed that cANGPTL4 binds and activates integrin ?5?1-mediated Rac1/PAK signaling to weaken cell-cell contacts. cANGPTL4 subsequently associated with and declustered VE-cadherin and claudin-5, leading to endothelial disruption. Interfering with the formation of these cANGPTL4 complexes delayed vascular disruption.
    Type: Application
    Filed: August 8, 2012
    Publication date: August 28, 2014
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventor: Nguan Soon Tan
  • Publication number: 20120207770
    Abstract: The invention provides an antibody specific to the ANGPTL4 protein capable of neutralizing proliferation and methods of making and using the same. The antibody of the invention is further directed to the C terminal region of the protein and may be capable of neutralizing cell proliferation and treating cancer. The antibody may be monoclonal and or humanized antibody.
    Type: Application
    Filed: October 14, 2010
    Publication date: August 16, 2012
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Nguan Soon Tan, Han Chung Chong, Ming Jie Tan, Royston Huang
  • Patent number: 6733997
    Abstract: A universal secretory signal originally derived from a piscine vitellogenin (Vtg) gene is inserted into various expression vectors for driving the secretion of the recombinant protein into the culture medium. This enhances the detection, quantification and downstream scaled-up purification of a recombinant protein of interest. The secretory signal system is very versatile, being conveniently and widely applicable to an array of heterologous host cells such as bacteria, yeast, insect, piscine, and mammalian cell lines (e.g., COS, CHO, NIH/3T3). The said secretory system is also applicable as a reporter vector for secretion of reporter proteins/enzymes, thus, enabling the detection of the reporter proteins (e.g., CAT, GFP) in the culture medium.
    Type: Grant
    Filed: October 26, 1999
    Date of Patent: May 11, 2004
    Assignee: National University of Singapore
    Inventors: Jeak Ling Ding, Nguan Soon Tan, Bow Ho, Toong Jin Lam