Abstract: The present invention provides nucleic acids sequences, viral particles, viruses, vectors systems, host cells, kits, apparatus, and methods of evolution of a gene product of a gene of interest. The nucleic acid sequences of the invention have been developed primarily for use in evolution of biomolecules of interest. Using a split, non-competent viral vector, the gene of interest can be stably and recombinantly integrated into the viral vector via in-frame insertion of the open reading frame of the gene of interest with an aspect of the native but attenuated viral genome. This configuration of the viral genome, leveraging a split viral vector and an aspect of a viral factor that has been shown to robustly interact with the split viral vector, enables the serial passaging of the recombinant viral particle in an indel and recombination-averse manner.

Abstract: An implantable device for cardiac assistance by direct compression, including a base forming a receptacle for receiving the lower part of a heart, a support for fixing the lower part of the heart to the base, at least one finger extending longitudinally between a free upper first end and a curved lower second end inside the base, the finger being mounted on the base via a first pivot connection, a contact interface mounted adjustably and movably on the free end, an actuator for actuating the tilting movement of the finger about the pivot connection, and a control unit for controlling the actuator is disclosed.

Abstract: A seal assembly for a rotary machine is positioned between a rotating component and a stationary component of the rotary machine. The seal assembly includes a seal bearing face that opposes the rotating component and a slide device. The slide device is positioned between different fluid pressure volumes in the rotary machine. The slide device axially moves toward the rotating component responsive to pressurization of the rotary machine. The slide device includes cross-over ports and the seal bearing face includes feed ports. The feed ports extend through the seal bearing face to form an aerostatic portion of a film bearing between the seal bearing face and the rotating component. The seal bearing face and/or the rotating component is a non-planar surface that, during rotating motion of the rotating component, forms an aerodynamic portion of the film bearing between the seal bearing face and the rotating component.

Abstract: An exhaust gas turbocharger may include a turbine and a compressor for compression of charge air for an internal combustion engine, and a controllable actuator and a component mechanically adjustable via the actuator. The compressor may include a compressor casing through which charge air is flowable. A holding device may be integrally disposed on the compressor casing. The actuator may be coupled to the holding device, and may be secured to the compressor casing via the holding device. The holding device may have at least one integrally formed protective contour that may extend around the actuator in certain regions at a separation distance from the actuator, and may enclose the actuator in certain regions, such that the actuator is shielded in certain regions from external influences via the at least one protective contour.

Abstract: An aspect of the present disclosure is directed to a seal assembly. The seal assembly includes a fluid bearing wall including a bearing face defining a fluid opening through the fluid bearing wall. The seal assembly further includes a tilt member is extended from and attached to the fluid bearing wall. The tilt member defines a fluid passage therethrough in fluid communication with the fluid opening at the bearing face of the fluid bearing wall. The seal assembly still further includes a seal body surrounding the tilt member. A cavity is defined between the tilt member and the seal body. The seal assembly further includes a spring member coupled to the seal body and the fluid bearing wall. A passage is defined between the fluid bearing wall and the seal body.

Abstract: A seal assembly for a rotary machine is positioned between a rotating component and a stationary component of the rotary machine. The seal assembly includes a seal bearing face that opposes the rotating component and a slide device. The slide device is positioned between different fluid pressure volumes in the rotary machine. The slide device axially moves toward the rotating component responsive to pressurization of the rotary machine. The slide device includes cross-over ports and the seal bearing face includes feed ports. The feed ports extend through the seal bearing face to form an aerostatic portion of a film bearing between the seal bearing face and the rotating component. The seal bearing face and/or the rotating component is a non-planar surface that, during rotating motion of the rotating component, forms an aerodynamic portion of the film bearing between the seal bearing face and the rotating component.

Abstract: An aspect of the present disclosure is directed to a seal assembly for a turbo machine. The seal assembly includes a fluid bearing wall including a bearing face in which the bearing face defines a fluid opening through the fluid bearing wall. The seal assembly further includes a seal body extended circumferentially relative to a centerline axis. The seal body defines a cavity extended at least partially circumferentially through the seal body. A fluid passage is defined through the seal body in fluid communication with the fluid opening through the fluid bearing wall.

Abstract: A seal assembly for a rotary machine is positioned between a rotating component and a stationary component of the rotary machine. The seal assembly includes a seal bearing face that opposes the rotating component and a slide device. The slide device is positioned between different fluid pressure volumes in the rotary machine. The slide device axially moves toward the rotating component responsive to pressurization of the rotary machine. The slide device includes cross-over ports and the seal bearing face includes feed ports. The feed ports extend through the seal bearing face to form an aerostatic portion of a film bearing between the seal bearing face and the rotating component. The seal bearing face and/or the rotating component is a non-planar surface that, during rotating motion of the rotating component, forms an aerodynamic portion of the film bearing between the seal bearing face and the rotating component.

Abstract: A seal assembly for a rotary machine includes a seal bearing face that opposes a rotating component of the machine and a slide device coupled with the seal bearing face. The slide device axially moves toward the rotating component responsive to pressurization of the rotary machine. The slide device includes cross-over ports and the seal bearing includes feed ports. The feed ports extend through the seal bearing face to form aerostatic portions of a film bearing between the seal bearing face and the rotating component. The seal bearing face and/or the rotating component has a non-planar surface that, during rotating motion of the rotating component relative to the face of the seal bearing face, forms aerodynamic portions of the film bearing.

Abstract: A display device includes an LCD panel comprising blue color filters, green color filters and red color filters, and a light source for providing light to the LCD panel. The light has a spectrum with first, second and third components. The first component has at least one peak wavelength in a first wavelength range from about 480.1 nm to about 510 nm. The second component has a second wavelength range that is perceived as a green color. The third component has a third wavelength range that is perceived as a red or orange-red color by human eyes. The green color filters are adapted such that they do not transmit the first component of light or transmit a minimal amount of the first component of light so as to prevent a distortion or shift of a CIE coordinate of a filtered green light by the first component of light.

Abstract: An exhaust gas turbocharger may include a turbine and a compressor for compression of charge air for an internal combustion engine, and a controllable actuator and a component mechanically adjustable via the actuator. The compressor may include a compressor casing through which charge air is flowable. A holding device may be integrally disposed on the compressor casing. The actuator may be coupled to the holding device, and may be secured to the compressor casing via the holding device. The holding device may have at least one integrally formed protective contour that may extend around the actuator in certain regions at a separation distance from the actuator, and may enclose the actuator in certain regions, such that the actuator is shielded in certain regions from external influences via the at least one protective contour.

Abstract: A seal assembly for a rotary machine includes a seal bearing face that opposes a rotating component of the machine and a slide device coupled with the seal bearing face. The slide device axially moves toward the rotating component responsive to pressurization of the rotary machine. The slide device includes cross-over ports and the seal bearing includes feed ports. The feed ports extend through the seal bearing face to form aerostatic portions of a film bearing between the seal bearing face and the rotating component. The seal bearing face and/or the rotating component has a non-planar surface that, during rotating motion of the rotating component relative to the face of the seal bearing face, forms aerodynamic portions of the film bearing.

Abstract: A seal assembly for a rotary machine is positioned between a rotating component and a stationary component of the rotary machine. The seal assembly includes a seal bearing face that opposes the rotating component and a slide device. The slide device is positioned between different fluid pressure volumes in the rotary machine. The slide device axially moves toward the rotating component responsive to pressurization of the rotary machine. The slide device includes cross-over ports and the seal bearing face includes feed ports. The feed ports extend through the seal bearing face to form an aerostatic portion of a film bearing between the seal bearing face and the rotating component. The seal bearing face and/or the rotating component is a non-planar surface that, during rotating motion of the rotating component, forms an aerodynamic portion of the film bearing between the seal bearing face and the rotating component.

Abstract: An aspect of the present disclosure is directed to a seal assembly for a turbo machine. The seal assembly includes a fluid bearing wall including a bearing face in which the bearing face defines a fluid opening through the fluid bearing wall. The seal assembly further includes a seal body extended circumferentially relative to a centerline axis. The seal body defines a cavity extended at least partially circumferentially through the seal body. A fluid passage is defined through the seal body in fluid communication with the fluid opening through the fluid bearing wall.

Abstract: An aspect of the present disclosure is directed to a seal assembly. The seal assembly includes a fluid bearing wall including a bearing face defining a fluid opening through the fluid bearing wall. The seal assembly further includes a tilt member is extended from and attached to the fluid bearing wall. The tilt member defines a fluid passage therethrough in fluid communication with the fluid opening at the bearing face of the fluid bearing wall. The seal assembly still further includes a seal body surrounding the tilt member. A cavity is defined between the tilt member and the seal body. The seal assembly further includes a spring member coupled to the seal body and the fluid bearing wall. A passage is defined between the fluid bearing wall and the seal body.

Abstract: Aspects of the invention include a display device including a liquid crystal display (LCD) panel comprising a plurality of blue color filters, a plurality of green color filters, and a plurality of red color filters; and a light source configured to provide light to the LCD panel. The light has a spectrum with a blue component, a green component and a red component. In one embodiment, the blue component has at least one peak wavelength in between 465 nm to 495 nm. In another embodiment, the blue component has an intensity being broadly distributed over a wavelength range of 430 nm to 495 nm. The plurality of green color filters has a transmission cut off wavelength being 480 nm or greater than 480 nm. The plurality of blue color filters has a transmission cut off wavelength being no greater than 500 nm.

Abstract: Described herein is a system and method for detecting and compensating for an anomaly in three-dimensional object fabrication. A wall thickness computation component computes a wall thickness of a three-dimensional object to be fabricated. An edge map generation component generates an edge map for one or more portions of the three-dimensional object to be fabricated satisfying one or more wall thickness criteria. The wall thickness criteria includes, for example, a computed wall thickness less than an extrusion width of a fabrication apparatus, a computed wall thickness greater than an extrusion width and less than twice the extrusion width and/or a computed wall thickness not an integer multiple of the extrusion width. A tool path generation component generates a tool path based on the generated edge map.

Abstract: Described herein is a system and method system for fabricating a three-dimensional object using a plurality of extruders. Information including two-dimensional segments of a layer of a three-dimensional object to be fabricated using the plurality of extruders is received. Closed contour, two-dimensional polygons are computed based on the two-dimensional segments. Tool path(s) are generated based on the computed closed contour two-dimensional polygons. The generated tool path(s) are provided to a fabrication apparatus.

Abstract: An aspirating face seal assembly for a turbo-machine including a rotor assembly having a first radially extending portion defining a rotor surface is disclosed. The aspirating face seal assembly includes a seal body including a second radially extending portion defining a bearing surface and having a plurality of return channels. The second radially extending portion is disposed in the turbo-machine such that the bearing surface is disposed facing the rotor surface. The aspirating face seal assembly further includes an annular ring including one or more openings. The annular ring is concentrically disposed on the second radially extending portion and between the rotor surface and the second radially extending portion and configured to rotate in an event of rub between the first radially extending portion and the annular ring. A turbo-machine including the aspirating face seal assembly and a method for operating an aspirating face seal are also disclosed.

Abstract: A medicinal drug is administered to a person for treating allergic rhinitis, hemorrhoids, toothache, bromhidrosis, or urticaria. The medicinal drug is formed at least partially with salt of peroxymonosulfuric acid, preferably potassium hydrogen peroxymonosulfate.