Abstract: The present invention relates to chemical compounds having a general formula I wherein A, B, C1, C2, D, L1, L2 and R3-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Tie-2 and Aurora kinase enzymes thereby influencing angiogenesis and the process of cell cycle and cell proliferation, respectively, to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of various protein kinases.

Abstract: An apparatus, functioning as a user-input device (UID) to a computer by using a communication link, receives/transmits additional I/O signals via the same link. The I/O signals may be analog or digital. One implementation of the apparatus, made wireless and supported by speech processing software, allows its user to interact with the computer remotely. The inventive apparatus comprises means for converting the I/O signals into/from the digital I/O streams in such a manner as to be transferable to/from the computer along with the UI information via the same communication link. The apparatus, while functioning as a UID, may handle the I/O signals coming from/to an external I/O device, such as a fax/modem device or even another conventional UID. The apparatus, while performing as a UID, may include the complete functionality of an external I/O device handling the I/O signals.