Abstract: Chemical compounds for the treatment of myeloid neoplasms and solid tumors are described, where the compounds were identified through a screening process assessing the binding affinity of the compounds to a synthesized fragment of Setbp1 protein.

Abstract: Systems and methods for independently managing wireless transmission by individual spectrum access systems in a radio frequency spectrum shared by a plurality of spectrum access systems. An example method includes: receiving, by the spectrum access system, an interference budget from a sensor; determining, by the spectrum access system, secondary users managed by the spectrum access system in a radio frequency spectrum shared by a plurality of spectrum access systems; managing a move list for the spectrum access system independently of the other spectrum access systems in an absence of exchange of spectrum grant information with the other spectrum access systems; and determining the move list for the spectrum access system from a first moment and a second moment of an aggregate interference distribution such that the spectrum access system provides grants to its secondary users in a dynamic protection area of the spectrum access system.

Abstract: Substituted quinazoline compounds, conjugates, and pharmaceutical compositions for use in the treatment of cancer are disclosed herein. The disclosed compounds are useful, among other things, in the inhibition of CDK. In certain aspects, the disclosure generally relates to substituted quinolinone amide compounds or salts of Formula (I), (IA), (IAA), (IAAA), (IB), (IBB), (IC), (ICC), (II), or (IIA) and pharmaceutical compositions thereof.

Abstract: Substituted aza-quinazoline compounds, conjugates, and pharmaceutical compositions for use in the treatment of cancer are disclosed herein. The disclosed compounds are useful, among other things, in the inhibition of CDK. In certain aspects, the disclosure generally relates to substituted quinolinone amide compounds or salts of Formula (I), (IA), (IAA), (IAAA), (IB), (IBB), (IC), (ICC), (ID), (IDD), (IE), and (IEE) and pharmaceutical compositions thereof.

Abstract: The present invention relates to HLA-DR/CII peptide complexes comprising a chondroitinbinding peptide at the C-terminal end of the polypeptide comprising the H LA-DR alpha chain and/or the H LA-DR beta chain, wherein the CII peptide is fused to the N-terminus of the H LA-DR alpha chain or the H LA-DR beta chain by a linker peptide, for use in treating chronic inflammatory disease, such as arthritis, in human patients. The lysines in the CII peptide, particularly the first lysine in the CII peptide, may be post-translationally modified. The invention further relates to methods of producing said HLA-DR/CII peptide complexes in mammalian cells.

Abstract: Provided herein are compositions made from a matrix and encapsulated phase change material particles dispersed therein, and electronic devices assembled therewith.

Abstract: The present disclosure relates to compounds that inhibit SETBP1 or XP01 activities. Also disclosed are methods of using such compounds to increase the expression of embryonic and fetal hemoglobin molecules, and to treat sickle cell disease and ?-thalassemia. The present invention relates to unexpected findings that transcription factor SETBP1 regulates embryonic and fetal hemoglobin repression, and inhibition of SETBP1 can induce the expression of embryonic and fetal hemoglobins.

Abstract: The disclosure provides compositions and methods for modifying a target nucleic acid. In some embodiments, a composition can include a targetable nuclease, a DNA-binding protein, and a donor template comprising a homology directed repair (HDR) template and one or more DNA-binding protein target sequences. In some embodiments, a composition can include a Cas protein, one or more single guide RNAs (sgRNAs), and an anionic polymer.

Abstract: Systems and methods for independently managing wireless transmission by individual spectrum access systems in a radio frequency spectrum shared by a plurality of spectrum access systems. An example method includes: receiving, by the spectrum access system, an interference budget from a sensor; determining, by the spectrum access system, secondary users managed by the spectrum access system in a radio frequency spectrum shared by a plurality of spectrum access systems; managing a move list for the spectrum access system independently of the other spectrum access systems in an absence of exchange of spectrum grant information with the other spectrum access systems; and determining the move list for the spectrum access system from a first moment and a second moment of an aggregate interference distribution such that the spectrum access system provides grants to its secondary users in a dynamic protection area of the spectrum access system.

Abstract: Chemical compounds for the treatment of myeloid neoplasms and solid tumors are described, where the compounds were identified through a screening process assessing the binding affinity of the compounds to a synthesized fragment of Setbp1 protein.

Abstract: Embodiments may relate to a silicon photonic chip, and particularly a back absorber within the silicon photonic chip. The back absorber may include a substrate material with a slab portion that includes a doped portion of the substrate material. The back absorber may be positioned at the backside of a laser that is configured to project light along a waveguide of the silicon photonic chip. Other embodiments may be described or claimed.

Abstract: A honing tool (1) for honing a cylindrical external surface (2) of a rod (3). The tool comprises a plurality of honing inserts (4), adapted to hone a metal, and a support (5) for the honing inserts. The inserts (4) are carried by the support (5) and define a passage (6) around which the inserts (4) are to be found and in which the cylindrical external surface (2) of the rod (3) is insertable. The tool (1) includes a plurality of sliding skids (7) carried by the support (5), the sliding skids (7) and the honing inserts (4) being arranged to be capable of coming simultaneously into contact against the cylindrical external surface (2) of the rod (3) when the rod is placed inside the passage (6) and so as to be able to center the cylindrical external surface (2) inside the passage (6).

Abstract: Provided herein are compositions made from a matrix and a hydrated salt of an acid and a Group I or II element of the Periodic Table, and electronic devices assembled therewith.

Abstract: Provided herein are compositions made from a matrix and encapsulated phase change material particles dispersed therein, and electronic devices assembled therewith.

Abstract: In an input device for inputting characters on a user interface by handwriting, the movement of an input unit, in particular a finger of a user, is detected and converted to an input pattern corresponding to the detected movement. The input pattern is compared with stored characters of a character set, and if the input pattern sufficiently matches one of the stored characters, the character is selected. During the input, the user receives acoustic feedback about the input process, such that the acoustic feedback signal is output in a constant manner outside a defined edge area of the user interface and is output in an incremental or continuous manner at a decreasing distance from the edge in a defined edge area of the user interface.

Abstract: A honing tool (1) for honing a cylindrical external surface (2) of a rod (3). The tool comprises a plurality of honing inserts (4) adapted to hone a metal; and a support (5) for the honing inserts. The inserts (4) are carried by the support (5) and define a passage (6) around which the inserts (4) are to be found and in which the cylindrical external surface (2) of the rod (3) is insertable. The tool (1) includes a plurality of sliding skids (7) carried by the support (5), the sliding skids (7) and the honing inserts (4) being arranged to be capable of coming simultaneously into contact against the cylindrical external surface (2) of the rod (3) when the rod is placed inside said passage (6) and so as to be able to center the cylindrical external surface (2) inside said passage (6).

Abstract: A method and display for displaying the operating range of an electric drive vehicle and a display for carrying out same are provided. The battery energy in a vehicle is detected, and a maximum operating range of the vehicle is determined therefrom. At least one battery service station is selected as destination point for determining the maximum operating range. Based on a starting point, a reachability threshold is determined. If exceeded, the vehicle will be unable to reach the destination point with the current battery energy available, wherein said reachability threshold is displayed as an operating range in a map illustration. During the determination of the reachability threshold, the current location is used as the starting point and the current battery energy of the vehicle is used, both of which are updated at pre-defined intervals while the vehicle is moving.

Abstract: Provided herein are electronic devices assembled with thermally insulating layers.

Abstract: Provided herein are electronic devices assembled with thermally insulating layers.

Abstract: In an input device for inputting characters on a user interface by handwriting, the movement of an input unit, in particular a finger of a user, is detected and converted to an input pattern corresponding to the detected movement. The input pattern is compared with stored characters of a character set, and if the input pattern sufficiently matches one of the stored characters, the character is selected. During the input, the user receives acoustic feedback about the input process, such that the acoustic feedback signal is output in a constant manner outside a defined edge area of the user interface and is output in an incremental or continuous manner at a decreasing distance from the edge in a defined edge area of the user interface.