Abstract: This application relates to sulfoxide and sulfone compounds of Formula (X) and other compounds that may be useful to activate glucokinase as part of a treatment for various diseases including diabetes. Further encompassed are pharmaceutical compositions comprising a compound according to the invention.

Abstract: A catheter having a distal assembly with multiple spines with proximal ends affixed to the catheter and free distal ends. The spines have different lengths so distal ends of the spines trace different circumferences along an inner tissue surface of a tubular region to minimize risk of vein stenosis. The spine lengths can be configured so that the distal ends trace a helical pattern. The distal assembly may have a plunger which deflects the spines when moved longitudinally relative to the distal assembly. The catheter may include a second distal assembly distal of a first distal assembly wherein the first and second distal assemblies are separated by a fixed distanced or an adjustable distance.

Abstract: A large lumen guide catheter (10) has an elongate tubular body (22), which has an outer surface (24), an inner surface (44), and a braided wire layer between the inner surface and the outer surface, wherein the wires winding a first helical direction are thicker and wider than the wire winding in a second helical direction opposite the first helical direction.

Abstract: A catheter having a distal assembly with multiple spines with proximal ends affixed to the catheter and free distal ends. The spines have different lengths so distal ends of the spines trace different circumferences along an inner tissue surface of a tubular region to minimize risk of vein stenosis. The spine lengths can be configured so that the distal ends trace a helical pattern. The distal assembly may have a plunger which deflects the spines when moved longitudinally relative to the distal assembly. The catheter may include a second distal assembly distal of a first distal assembly wherein the first and second distal assemblies are separated by a fixed distanced or an adjustable distance.

Abstract: A large lumen guide catheter (10) has an elongate tubular body (22), which has an outer surface (24), an inner surface (44), and a braided wire layer between the inner surface and the outer surface, wherein the wires winding a first helical direction are thicker and wider than the wire winding in a second helical direction opposite the first helical direction.

Abstract: Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

Abstract: A catheter having a distal assembly with multiple spines with proximal ends affixed to the catheter and free distal ends. The spines have different lengths so distal ends of the spines trace different circumferences along an inner tissue surface of a tubular region to minimize risk of vein stenosis. The spine lengths can be configured so that the distal ends trace a helical pattern. The distal assembly may have a plunger which deflects the spines when moved longitudinally relative to the distal assembly. The catheter may include a second distal assembly distal of a first distal assembly wherein the first and second distal assemblies are separated by a fixed distanced or an adjustable distance.

Abstract: Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

Abstract: Methods for preparing an inhibitor of dipeptidyl peptidase IV, as well as formulations of such inhibitors of dipeptidyl peptidase IV that have a high degree of stability including under warm, humid storage conditions.

Abstract: Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.

Abstract: Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.

Abstract: Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.

Abstract: The present invention relates to imidazopyridine and imidazopyrimidine derivatives that act as cannabinoid receptor ligands, e.g., CB2 ligands. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Abstract: Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.

Abstract: The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.

Abstract: The present invention relates to pyridoazepine derivatives that act as 5-HT ligands, e.g., 5-HT2C ligands. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Abstract: An enclosed needle catheter insertion device (10) includes a catheter (12) and a needle insertion device (14) which are held together by cooperating arms (52, 53) with one or more detents (56) cooperating with a radially projecting surface (26) of the catheter hub (16). Insertion device (14) includes a guard housing (30) to enclose a needle (34) in a shielded position and a support housing (32) supporting the needle (34) for movement between a ready position, with the tip (36) of the needle (34) exposed, to the shielded position. Cooperating lock elements (47, 78) are provided for the housings (30, 32) which are positioned to define a lock actuation stage between the ready and shielded positions, whereat the needle is still within a passageway (54) defined by the cooperating arms (52, 53).

Abstract: A generally rigid molded plastic catheter hub attachment (16, 52, 74) includes one or more co-molded elastomeric gaskets (22, 58).