Patents by Inventor Niala Bhagirath

Niala Bhagirath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of SYK
    Patent number: 10112928
    Abstract: The present invention relates to the use of novel compounds of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: October 30, 2018
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Niala Bhagirath, Joshua Kennedy-Smith, Nam T. Le, Matthew C. Lucas, Fernando Padilla, Michael Soth
  • 1 H-pyrazole and 4,5-disubstituted thiazole inhibitors of SYK
    Patent number: 9988378
    Abstract: The present invention relates to the use of novel compounds of formula (I), wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: June 5, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Niala Bhagirath, Joshua Kennedy-Smith, Matthew C. Lucas, Fernando Padilla
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20150284394
    Abstract: This application discloses compounds according to generic Formula I wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: October 23, 2013
    Publication date: October 8, 2015
    Inventors: Niala Bhagirath, Romyr Dominique, Joshua Kennedy-Smith, Francisco Javier Lopez-Tapia, Eric Mertz, Qi Qiao, Sung-Sau So
  • INHIBITORS OF SYK
    Publication number: 20150284367
    Abstract: The present invention relates to the use of novel compounds of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Application
    Filed: October 15, 2013
    Publication date: October 8, 2015
    Inventors: Niala Bhagirath, Joshua Kennedy-Smith, Nam T. Le, Matthew C. Lucas, Fernando Padilla, Michael Soth
  • 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK
    Publication number: 20150266874
    Abstract: The present invention relates to the use of novel compounds of formula (I), wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Application
    Filed: October 23, 2013
    Publication date: September 24, 2015
    Inventors: Niala Bhagirath, Joshua Kennedy-Smith, Matthew C. Lucas, Fernando Padilla