Abstract: Provided herein are methods of treating or ameliorating a pediatric cholestatic liver disease by non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a pediatric liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an ASBTI or a pharmaceutically acceptable salt thereof.

Abstract: This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

Abstract: Methods and systems disclosed herein relate generally to constructing graph models to represent constraints corresponding to various investigatory events and navigating the graph models to identify populations for the investigatory events.

Abstract: Methods and systems disclosed herein relate generally to generating and using graph models to perform entity-specific mappings to investigatory events. More specifically, data-reliability metrics are used to selectively use proxy nodes in graph-model trajectories during generation of the mappings.

Abstract: Methods and systems disclosed herein relate generally to using graph structures and parent-child node configurations to facilitate data integration across corresponding investigatory events.

Abstract: An optical touch-sensitive device is able to determine the locations of multiple simultaneous touch events on a surface. The optical touch-sensitive device includes multiple emitters and detectors. Each emitter produces optical beams which are received by the detectors. Touch events on the surface disturb the optical beams received by the detectors. Based on the disturbed beams, a map of the touch activity on the surface is generated. Touch characteristics and touch types for each touch event are determined from the map. By applying the touch characteristics and touch types to contextual information, a machine learned model, or a set of predefined rules, touches can be classified as wanted or unwanted touch events. Unwanted touch events may be ignored to improve user experience.

Abstract: A display arrangement suitable for stadiums, shopping malls, or other locations with open areas includes an upstanding support structure having a plurality of support structure sides on which stacked display screen arrangements are disposed. An enclosure surrounds all sides of the upstanding support structure, and has a plurality of enclosure sides on which stacked display screen arrangements are arrayed. The display arrangement utilizes at least one processor by which the stacked display screen arrangements on the enclosure sides allow for integrated foreground, middle ground, and background movements. At least one of the upstanding support structure and the enclosure includes a particularly adapted cooling arrangement.

Abstract: Methods and systems for managing a graphical user interface involve, for example, one or more processors displaying on a display screen a visualization of a hub element defined in part by an arc-shaped boundary portion and defining a badge element within the visualization of the hub element. Thereafter, a radial menu element may be animated by the one or more processors for rotation to a position adjacent and extending radially from the arc-shaped boundary portion of the hub element and defined in part by an arc-shaped boundary portion of the radial menu element spaced apart from the arc-shaped boundary portion of the hub element.

Abstract: A touch sensitive surface has emitters and detectors arranged around a periphery of the touch sensitive surface. The emitters produce optical beams that are received by the detectors. A stylus is configured to disturb one or more of the optical beams by a variable amount when in contact with the touch sensitive surface. The variable amount depends on an amount of force applied to the stylus towards the touch sensitive surface. A controller of the touch sensitive surface is configured to determine the touch strength of a touch event performed by the stylus based on disturbances of one or more of the optical beams. The touch strength provides a measure of the amount of force applied to the stylus.

Abstract: Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.

Abstract: Devices, systems and methods for magnetically separating paramagnetic beads for biomolecule isolation and processing are disclosed.

Abstract: Logical scalable units (LSU) can be used within a single network data center to provide stateful scalability. However, LSUs are not suitable for operating across multiple network data centers in order to provide geographical redundancy in active-active scenarios while providing high availability. This is because the latencies associated with replicating full session information are unacceptably slow. An additional component in the LSU (known as an LSU Frontend) can be used to replicate a small subset of session information between LSUs. This subset of session information may be enough to enable LSUs to process requests in an acceptable way rather than outright failing. This may be particularly advantageous in scenarios where the requests relate to Voice over LTE calls, because outright failure is very perceivable to subscribers, and it causes resource leakage within the telecommunications network.

Abstract: Logical scalable units (LSU) can be used within a single network data center to provide stateful scalability. However, LSUs are not suitable for operating across multiple network data centers in order to provide geographical redundancy in active-active scenarios while providing high availability. This is because the latencies associated with replicating full session information are unacceptably slow. An additional component in the LSU (known as an LSU Frontend) can be used to replicate a small subset of session information between LSUs. This subset of session information may be enough to enable LSUs to process requests in an acceptable way rather than outright failing. This may be particularly advantageous in scenarios where the requests relate to Voice over LTE calls, because outright failure is very perceivable to subscribers, and it causes resource leakage within the telecommunications network.

Abstract: Logical scalable units (LSU) can be used within a single network data center to provide stateful scalability. However, LSUs are not suitable for operating across multiple network data centers in order to provide geographical redundancy in active-active scenarios while providing high availability. This is because the latencies associated with replicating full session information are unacceptably slow. An additional component in the LSU (known as an LSU Frontend) can be used to replicate a small subset of session information between LSUs. This subset of session information may be enough to enable LSUs to process requests in an acceptable way rather than outright failing. This may be particularly advantageous in scenarios where the requests relate to Voice over LTE calls, because outright failure is very perceivable to subscribers, and it causes resource leakage within the telecommunications network.

Abstract: Logical scalable units (LSU) can be used within a single network data center to provide stateful scalability. However, LSUs are not suitable for operating across multiple network data centers in order to provide geographical redundancy in active-active scenarios while providing high availability. This is because the latencies associated with replicating full session information are unacceptably slow. An additional component in the LSU (known as an LSU Frontend) can be used to replicate a small subset of session information between LSUs. This subset of session information may be enough to enable LSUs to process requests in an acceptable way rather than outright failing. This may be particularly advantageous in scenarios where the requests relate to Voice over LTE calls, because outright failure is very perceivable to subscribers, and it causes resource leakage within the telecommunications network.

Abstract: Provided are a computer-implemented method and system for determining the level of authentication required for a transaction, the method comprising operating a processor to: receive a transaction request associated with a payment card; compare geolocation data of the transaction request with geolocation data of a mobile device associated with a cardholder of the payment card; and based on the comparison, determine the level of authentication required for the transaction.

Abstract: Provided herein are methods of treating or ameliorating a pediatric cholestatic liver disease by non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a pediatric liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an ASBTI or a pharmaceutically acceptable salt thereof.

Abstract: This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.