Patents by Inventor Niamh Cawley

Niamh Cawley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED GROWTH HORMONE
    Publication number: 20110135614
    Abstract: The invention provides, a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provides a nucleic acid molecule encoding a GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell.
    Type: Application
    Filed: January 19, 2011
    Publication date: June 9, 2011
    Applicant: THE UNITED STATES OF AMERICA, REPRESENTED BY, DEPA RTMENT OF HEALTH
    Inventors: Yoke Peng Loh, Niamh Cawley, Bruce J. Baum, Christopher R. Snell
  • Nucleic acids encoding growth hormone with a modified RSP sorting signal
    Patent number: 7888070
    Abstract: The invention provides a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provides a nucleic acid molecule encoding a GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: February 15, 2011
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Yoke Peng Loh, Niamh Cawley, Bruce J. Baum, Christopher R. Snell
  • MODIFIED GROWTH HORMONE
    Publication number: 20080008691
    Abstract: The invention provides a nucleic acid molecule encoding a growth hormone (GH) which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell.
    Type: Application
    Filed: September 6, 2007
    Publication date: January 10, 2008
    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPT.
    Inventors: Yoke Peng Loh, Niamh Cawley, Bruce Baum, Christopher Snell
  • Modified growth hormone
    Patent number: 7271150
    Abstract: The invention provides a growth hormone (GH) in which amino acids within the regulated secretory pathway (RSP) sorting signal have been mutated as well as a GH in which the three-dimensional conformation of the RSP sorting signal has been altered, and a composition comprising an effective amount of such a GH in an excipient.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: September 18, 2007
    Assignee: United States of America, Represented by the Secretary, Department of Health and Human Services
    Inventors: Yoke Peng Loh, Niamh Cawley, Bruce J. Baum, Christopher R. Snell
  • Modified growth hormone
    Publication number: 20040158046
    Abstract: Growth hormone (GH) in which the regulated secretory pathway (RSP) sorting signal has been mutated as well as GH in which the three-dimensional conformation of the RSP sorting signal has been altered, a composition comprising an effective amount of such a GH in an excipient, a nucleic acid molecule encoding GH in which the RSP sorting signal has been mutated such the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell as well as a nucleic acid molecule encoding GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell, a vector comprising such a nucleic acid molecule, an isolated host cell comprising such a vector, a method of treating growth hormone deficiency (GHD) and other diseases in a mammal by administering to the mammal the aforementioned composition, nucleic acid or vector or host cells which have been contacted ex vivo with an aforementioned n
    Type: Application
    Filed: November 14, 2003
    Publication date: August 12, 2004
    Inventors: Yoke Peng Loh, Niamh Cawley, Bruce J Baum, Christopher R Snell