Patents by Inventor Nic Bloomfield

Nic Bloomfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10008376
    Abstract: The present teachings are directed to methods and systems for the selection of ions for subsequent ion fragmentation in the analysis of a sample. Rather than select the most intense subset of precursor ions for further analysis in an attempt to maximize the number of high quality, identifiable MS/MS spectra, in some settings, systems and methods for analyzing and 5 identifying precursor ions for further processing can benefit from a discovery approach in which precursor ions are selected randomly/stochastically.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: June 26, 2018
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Nic Bloomfield, Stephen A. Tate
  • Publication number: 20170338091
    Abstract: The present teachings are directed to methods and systems for the selection of ions for subsequent ion fragmentation in the analysis of a sample. Rather than select the most intense subset of precursor ions for further analysis in an attempt to maximize the number of high quality, identifiable MS/MS spectra, in some settings, systems and methods for analyzing and 5 identifying precursor ions for further processing can benefit from a discovery approach in which precursor ions are selected randomly/stochastically.
    Type: Application
    Filed: October 27, 2015
    Publication date: November 23, 2017
    Inventors: Nic Bloomfield, Stephen A. Tate
  • Patent number: 8618474
    Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: December 31, 2013
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Chris M. Lock, Nic Bloomfield
  • Publication number: 20110315870
    Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.
    Type: Application
    Filed: September 9, 2011
    Publication date: December 29, 2011
    Applicants: Applera Corporation, MDS Analytical Technologies, a business unit of MDS Inc., doing buiness through its Sciex division
    Inventors: Chris M. LOCK, Nic Bloomfield
  • Patent number: 8026479
    Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: September 27, 2011
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Chris M. Lock, Nic Bloomfield
  • Publication number: 20090236513
    Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.
    Type: Application
    Filed: March 12, 2009
    Publication date: September 24, 2009
    Applicants: MDS Analytical Technologies, a business unit of MDS Inc., doing buiness through its Sciex division, Applera Corporation
    Inventors: Chris M. LOCK, Nic BLOOMFIELD
  • Patent number: 7589318
    Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, a mass spectrometer includes an ion source for emitting a plurality of ions from a sample together with a detector positioned downstream of said ion source and configured to detect the impact of emitted ions on the detector. The mass spectrometer also includes a controller operatively coupled to the detector and to the ion source and configured to calculate the m/z for each detected ion. The controller comprises a mass defect filter configured to determine if the m/z for each detected ion falls within a pre-determined mass defect range. The mass spectrometer also includes data storage coupled to the controller, wherein the data storage is configured to store detected ion m/z data corresponding to the m/z for a detected ion if the m/z falls within the mass defect range. The mass spectrometer may also include an ion mass filter positioned downstream of the ion source and operatively coupled to the controller.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: September 15, 2009
    Assignees: MDS Inc., Applied Biosystems Inc.
    Inventors: Nic Bloomfield, Yves LeBlanc
  • Patent number: 7541575
    Abstract: Systems, methods, and computer program products useful in controlling the fragmentation of ions. Control of fragmentation is achieved by varying the collision energy imparted to precursor ions.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: June 2, 2009
    Assignees: MDS Inc., Applera Corporation
    Inventors: Christopher Mark Lock, Nic Bloomfield
  • Patent number: 7417223
    Abstract: A first mass spectrum and a second mass spectrum of the same ion sample can be analyzed to determine reaction pairs. These reaction pairs are determined based on a selected neutral difference by shifting the second mass spectrum by the neutral difference relative to the first mass spectrum to provide a shifted mass spectrum. Then, the shifted mass spectrum is compared with the first mass spectrum of the ion sample to determine the reaction pairs based on the neutral difference.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: August 26, 2008
    Assignees: MDS Inc., Applera Corporation
    Inventors: Yves LeBlanc, Nic Bloomfield
  • Patent number: 7351957
    Abstract: In the field of mass spectrometry, a method of obtaining a mass spectrum enriched with fragment ions while retaining the precursor ion. The technique includes varying the collision energy experienced by the precursor ion such that a range of fragmentations occur. Related methods are also disclosed for obtaining MS, MS2, MS3 and MSn spectra which are enriched with fragment ions.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: April 1, 2008
    Assignee: MDS Inc.
    Inventors: Nic Bloomfield, Yves Leblanc
  • Publication number: 20080054175
    Abstract: Systems and methods for calculating ion flux. In one embodiment, a mass spectrometer includes an ion source for emitting a beam of ions from a sample and at least one detector positioned downstream of said ion source. The at least one detector comprises a plurality of detector channels. The mass spectrometer also includes a controller operatively coupled to the plurality of detector channels. The controller is configured to: determine ion abundance data correlated to each detector channel; determine corrected ion abundance data correlated to each detector channel; determine confidence data corresponding to the ion abundance data for each of the detector channels; and determine a confidence weighted abundance estimate of the ion flux correlated to both the ion abundance data and to the confidence data.
    Type: Application
    Filed: August 29, 2007
    Publication date: March 6, 2008
    Inventors: Nic Bloomfield, Gordana Ivosev
  • Publication number: 20070164207
    Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, a mass spectrometer includes an ion source for emitting a plurality of ions from a sample together with a detector positioned downstream of said ion source and configured to detect the impact of emitted ions on the detector. The mass spectrometer also includes a controller operatively coupled to the detector and to the ion source and configured to calculate the m/z for each detected ion. The controller comprises a mass defect filter configured to determine if the m/z for each detected ion falls within a pre-determined mass defect range. The mass spectrometer also includes data storage coupled to the controller, wherein the data storage is configured to store detected ion m/z data corresponding to the m/z for a detected ion if the m/z falls within the mass defect range. The mass spectrometer may also include an ion mass filter positioned downstream of the ion source and operatively coupled to the controller.
    Type: Application
    Filed: January 5, 2007
    Publication date: July 19, 2007
    Inventors: Nic Bloomfield, Yves LeBlanc
  • Publication number: 20070158546
    Abstract: Systems, methods, and computer program products useful in controlling the fragmentation of ions. Control of fragmentation is achieved by varying the collision energy imparted to precursor ions.
    Type: Application
    Filed: January 11, 2007
    Publication date: July 12, 2007
    Inventors: CHRISTOPHER LOCK, NIC BLOOMFIELD
  • Publication number: 20070152149
    Abstract: Systems and methods for calculating ion flux. In one embodiment, a mass spectrometer includes an ion source for emitting a beam of ions from a sample through a plurality of pulses during an analysis period, and a detector positioned downstream of said ion source. A clock is provided which is configured to determine a repeatable series of bins, wherein each bin in the repeatable series will correspond to a corresponding pulse time segment in every pulse. Additionally a controller is provided which is operatively coupled to the detector and to the clock and configured to determine the total number of pulses during the analysis period. The controller is further configured to determine for at least one bin in the repeatable series, the number of corresponding pulse time segments in which no ion impact was detected during the analysis period.
    Type: Application
    Filed: January 4, 2007
    Publication date: July 5, 2007
    Inventors: Gordana Ivosev, Nic Bloomfield
  • Publication number: 20070096021
    Abstract: A first mass spectrum and a second mass spectrum of the same ion sample can be analyzed to determine reaction pairs. These reaction pairs are determined based on a selected neutral difference by shifting the second mass spectrum by the neutral difference relative to the first mass spectrum to provide a shifted mass spectrum. Then, the shifted mass spectrum is compared with the first mass spectrum of the ion sample to determine the reaction pairs based on the neutral difference.
    Type: Application
    Filed: October 28, 2005
    Publication date: May 3, 2007
    Inventors: Yves LeBlanc, Nic Bloomfield
  • Patent number: 7199361
    Abstract: In the field of mass spectrometry, a method of obtaining a mass spectrum enriched with fragment ions while retaining the precursor ion. The technique includes varying the collision energy experienced by the precursor ion such that a range of fragmentations occur. Related methods are also disclosed for obtaining MS, MS2, MS3 and MSn spectra which are enriched with fragment ions.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: April 3, 2007
    Assignee: MDS Inc.
    Inventors: Nic Bloomfield, Yves LeBlanc
  • Publication number: 20050277789
    Abstract: In the field of mass spectrometry, a method of obtaining a mass spectrum enriched with fragment ions while retaining the precursor ion. The technique includes varying the collision energy experienced by the precursor ion such that a range of fragmentations occur. Related methods are also disclosed for obtaining MS, MS2, MS3 and MSn spectra which are enriched with fragment ions.
    Type: Application
    Filed: April 2, 2003
    Publication date: December 15, 2005
    Applicant: MDS INC.,
    Inventors: Nic Bloomfield, Yves Leblanc
  • Publication number: 20050267152
    Abstract: The present invention relates to glycine transporter inhibiting compounds of formula (I): for treating disorders mediated by GlyT1, wherein R1—R9 are as in the description.
    Type: Application
    Filed: December 19, 2002
    Publication date: December 1, 2005
    Applicant: MDS Inc., doing business as MDS Sciex
    Inventors: Nic Bloomfield, Yves Leblanc
  • Publication number: 20040041090
    Abstract: In the field of mass spectrometry, a method of obtaining a mass spectrum enriched with fragment ions while retaining the precursor ion. The technique includes varying the collision energy experienced by the precursor ion such that a range of fragmentations occur. Related methods are also disclosed for obtaining MS, MS2, MS3 and MSn spectra which are enriched with fragment ions.
    Type: Application
    Filed: April 28, 2003
    Publication date: March 4, 2004
    Inventors: Nic Bloomfield, Yves LeBlanc