Abstract: An elongate stimulation assembly of an implantable stimulation device, including a first portion including a plurality of electrodes, lead wires extending from the first portion in electrical communication with the plurality of electrodes, the lead wires being located in an elongate lead body and a cage component extending in an elongate manner at least partially along with the lead wires, wherein the lead wires extend within the cage component.

Abstract: The present invention provides a method for generating a biomarker signature for a subject with cancer. The method comprises calculating an intra-tumour heterogeneity measure and an inter-tumour heterogeneity measure for a plurality of genes. This is done using training data from a plurality of subjects who have had cancer, where the training data comprises gene expression data for a plurality of genes for each subject. A biomarker signature is generated by applying a heterogeneity filter to select genes having both an intra-tumour heterogeneity below an intra-tumour heterogeneity threshold and an inter-tumour heterogeneity above an inter-tumour heterogeneity threshold.

Abstract: A database management engine provides a user interface that allows users to access and modify employee information in a database. The database includes entries for employees, and each database entry includes identifying information about the associated employee. A user can request to modify data within database entries, for instance in order to update information associated with an employee. Responsive to the request, the database management engine identifies liabilities associated with the database modification stemming from associated tax laws. Based on the identified tax liabilities, the engine computes the aggregate tax liability owed by the employer and/or employee. Before modifying a database entry, the engine modifies the user interface to include interface elements detailing the computed aggregate tax liability. The user explicitly can be required to confirm the database modification in view of the aggregate tax liability.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: Systems and methods for converting ordinary circular rotary motion into any non-circular motion that can be defined as a non-overlapping proper function in polar coordinates are provided. Embodiments disclosed teach how to make and use devices that can use the rotary output from motors, turbines and other sources of circular rotary motion to create motion that follows square, rectangular, triangular, or other useful paths. Such devices can be usefully employed as a replacement for conventional devices in applications where the desired path or area of coverage is not circular, including air-moving (fans), air-energy capture (turbines), surface finishing (sanding, polishing, cleaning), among many others.

Abstract: A quantum computing system includes a cryogenic chamber and an integrated circuit located in the chamber. The integrated circuit includes a substrate, a qubit formed on the substrate, and a dissipative element that is formed on the substrate and coupled to the qubit. When the qubit is tuned to a first flux value, the integrated circuit is enabled to perform quantum-computation operations on a set of quantum states of the qubit. The quantum states include a ground state and an excited state. When the qubit is tuned to a second flux value, the qubit is enabled to transfer energy associated with the excited state from the qubit to the dissipative element. Upon the energy transfer, the qubit is transitioned to the ground state. The dissipative element is enabled to dissipate the transferred energy to a portion of the substrate.

Abstract: A data processing system implements receiving a first input in a spreadsheet in a spreadsheet application, detecting an indication that the first input includes first executable program code, analyzing the first executable program code to identify first references to one or more first elements of the spreadsheet in the first executable program code, requesting spreadsheet data associated with the one or more first elements of the spreadsheet from the spreadsheet application, receiving the spreadsheet data from the spreadsheet application; executing the first executable program code using the spreadsheet data referenced in the first executable program code to obtain a first program code result and causing the spreadsheet application to display the first program code result in the spreadsheet application.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Embodiments of positioning systems and methods are disclosed herein. Embodiments of such positioning systems may include a hierarchy of positioning systems. Each of the positioning systems in the hierarchy may be adapted to move each positioning system lower in the hierarchy along with one or more end-effectors. A control system may control the positioning systems of the hierarchy using a control method comprising a coarse step, a refinement step, or an adaptive step.

Abstract: A suitcase having a base and a lid where the lid may be rotatable about a hinge from a closed configuration to an open configuration and may be secured, via one or more latching assemblies is disclosed. The lid may comprise an upper shell, and the base may comprise a lower shell. The upper shell and the lower shell may be seamlessly formed to create a water resistant and/or waterproof suitcase. The suitcase may have an extendable trolley handle assembly that is externally attached to the base of the suitcase using a plurality of mounting clips. The trolley handle assembly may comprise a pair of extrusion assemblies that are connected to the base of the suitcase and connected to each other by a grip. The suitcase may also have a removably secured interior liner. The interior liner may include a plurality of grommets and a plurality of fastener portions to releasably attach to the suitcase.

Abstract: An online concierge system receives information describing the progress of a picker servicing a batch of existing orders and predicts a first likelihood the picker will finish servicing the batch within a threshold amount of time based on the picker's progress and information describing the batch. If the first likelihood exceeds a threshold likelihood, the system accesses a machine learning model trained to predict a second likelihood the picker will accept a batch of new orders for servicing while servicing the batch of existing orders. The system applies the model to inputs including a set of attributes of the picker and the picker's progress to predict the second likelihood. The system matches batches of new orders with pickers based on the second likelihood and sends one or more requests to service one or more batches matched with the picker to a client device associated with the picker.

Abstract: A system for implementing a trial a field is provided. In an embodiment, the system is configured to generate a trial recommendation for a field and, based on field data for the field, compute a yield probabilities for the field. The system is also configured to generate a plurality of outcome-based values for the field based on the yield probabilities, compute crop values for each of the outcome-based values and a bushel per acre value, and cause display of an interface that dynamically displays each of the plurality of outcome-based values for the field based on a selected bushel per acre value. The system is further configured to receive user input changing a position of an interactive sliding widget in the interface, to change the bushel per acre value, and in response, compute a crop value for each of the outcome-based values based on the changed bushel per acre value.

Abstract: A method at an infrastructure unit of signaling a presence of a vulnerable road user, the method including receiving at least one report from a sensor unit, the at least one report indicating the presence of the vulnerable road user; composing a message indicating the presence of the vulnerable road user; and transmitting the message to road users proximate the infrastructure unit on a channel.

Abstract: Information identifying a message scanning system is encoded into URLs. A document management system can decode the identifying information to verify that a document accessed via a URL was accessed by a trusted entity rather than by an unknown user. The document management system sends a message including a URL to access a document. When a message scanning system known to the document management system reviews the message for threats, it encodes its identity into a modified form of the URL in the message and uses the modified URL to access the resource. The document management system can decode the identity of the messaging system using a decoding key. Based on the identification, the document management system updates records associated with the document to include the document acce by the message scanning system.

Abstract: An online concierge system receives information describing the progress of a picker servicing a batch of existing orders and a service request for an order. The system identifies picker attributes of the picker and order attributes of the order and each existing order of the set and accesses a machine learning model trained to predict a likelihood the picker will accept an add-on request to add the order to the batch of existing orders. To predict the likelihood, the system applies the model to the picker attributes, the progress of the picker, and the order attributes. The system determines a cost associated with sending the add-on request to the picker based on the likelihood and assigns the order to a set of orders based on the cost. The system sends the add-on request to the picker responsive to determining the order is assigned to the batch of existing orders.

Abstract: The invention provides methods for producing plants that reduce nitrous oxide (N2O) production from the soil in which they are grown. The invention involves expressing modified oleosins with artificially introduced cysteine residues in the plants. The plants optionally also express a triacylglycerol (TAG) synthesising enzyme. The invention also provides methods for reducing nitrous oxide (N2O) production from the soil in which the plants are grown. The invention also includes methods for the production of seed of the plants, and packages and use of such seed.

Abstract: Systems and methods for increasing fluidity of a shear-thinning material during transit using an energizer which is coupled to a conveyance and configured to impart energy to the shear-thinning material as it is transported by the conveyance, thereby increasing the fluidity of the Material source Conveyor Form material. The conveyance may comprise any of a wide variety of transport means, including pumps, hoses or other conduits, conveyor belts, bins or buckets, chutes, hoppers, or the like. The energizer may use elements that generate mechanical vibrations, electromagnetic waves, acoustic waves, or the like to transfer energy to the shear-thinning material. The energy-imparting elements may be at a localized portion of the conveyance, or at multiple locations along a transport path of the conveyance, and may be controlled by a controller based on such parameters as sensed characteristics of the shear-thinning material or environmental conditions.

Abstract: Disinfection cap includes housing comprising closed top, essentially cylindrical sidewall, and open bottom formed by the sidewall with opening to inner cavity within the housing for receiving mating feature of needleless connector. Disinfection sponge can be configured within inner cavity, with removable cover sealing opening to inner cavity to seal sponge within inner cavity prior to cap use. Inner cavity includes threads on inner surface of its sidewall that do not correspond to the mating feature of needleless connector. One thread engages with mating feature of needleless connector. Plurality of disinfection caps can be disposed on strip of IV pole hanging device such that each cap can be peeled off the strip unsealed for immediate use, or separated from the strip sealed for later use.

Abstract: The present invention relates to tetrahydroisoquinoline compounds that are KEAP1 binders and their incorporation in bifunctional compounds which are capable of acting as proteolysis-targeting chimeras. The present invention also relates to processes for the preparation of these bifunctional compounds, and to their use in the treatment of diseases or disorders associated with proteins that may be degraded through the KEAP1 E3 ligase.