Abstract: The present invention relates to compounds that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.

Abstract: A system for implementing a trial a field is provided. In an embodiment, the system is configured to generate a trial recommendation for a field and, based on field data for the field, compute a yield probabilities for the field. The system is also configured to generate a plurality of outcome-based values for the field based on the yield probabilities, compute crop values for each of the outcome-based values and a bushel per acre value, and cause display of an interface that dynamically displays each of the plurality of outcome-based values for the field based on a selected bushel per acre value. The system is further configured to receive user input changing a position of an interactive sliding widget in the interface, to change the bushel per acre value, and in response, compute a crop value for each of the outcome-based values based on the changed bushel per acre value.

Abstract: A cascade refrigeration system having a first refrigeration stage that defines a first fluid circuit and includes a first expansion device and a second refrigeration stage that defines a second fluid circuit, fluidically isolated from the first fluid circuit, that includes a second expansion device. The second expansion device includes a first capillary tube and a second capillary tube in parallel flow arrangement, and a second stage valve in fluid communication with the second capillary tube for selectively controlling flow of the second refrigerant through the second capillary tube in response to at least one operating condition of the refrigeration system without interrupting flow of the second refrigerant through the first capillary tube. The refrigeration system further includes at least one interstage heat exchanger in heat transferring communication with the first and second fluid circuits to exchange heat between the first and second refrigerants.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: An apparatus including an actuator and an electrode array support, wherein the apparatus is configured to insert an electrode array into a cochlea via controlled actuation of the actuator, wherein the controlled actuation is at least partially based on data that is at least partially based on electrical characteristics associated with the recipient.

Abstract: A fan controller for a ceiling fan is provided. The fan controller includes one or more switching devices configured to selectively couple the ceiling fan to a power source. The fan controller further includes a power meter circuit and one or more control devices. The one or more control devices are configured to obtain, via the power meter circuit, data indicative of power consumption of a fan motor of the ceiling. The one or more control devices are configured to determine the fan motor is configured in a first mode of a plurality of modes for the fan motor based, at least in part, on the data indicative of power consumption. The one or more control devices are configured to provide a notification to manipulate an input device on the ceiling fan to switch the fan motor from the first mode to a second mode of the plurality of modes.

Abstract: Disclosed is a range preview system that displays data from a relevant range of cells. The range preview system intelligently elides and contextualizes data ranges for efficient visualization. The range preview system optimizes space utilization by selectively collapsing rows and columns. For example, rows and columns that are referenced by a formula may be selected for inclusion in the range preview. This conserves screen real estate while providing users with a concise overview of data ranges. The range preview system may also infer labels, providing context during formula interpretation by associating references with nearby headers or other descriptions.

Abstract: Disclosed are novel approaches to debugging a formula in a spreadsheet environment. An execution trace shows step-by-step how a formula is evaluated. Instead of overwhelming users by displaying a step for every atomic evaluation, multiple evaluations are displayed in the same step. This makes the execution trace compact yet intuitive, enabling users to quickly and efficiently understand how the formula is evaluated. Visualizing formula execution in this way also reduces the computing and energy costs of excess recalculations incurred by trial-and-error based debugging techniques.

Abstract: An elongate stimulation assembly of an implantable stimulation device, including a first portion including a plurality of electrodes, lead wires extending from the first portion in electrical communication with the plurality of electrodes, the lead wires being located in an elongate lead body and a cage component extending in an elongate manner at least partially along with the lead wires, wherein the lead wires extend within the cage component.

Abstract: Systems and methods for converting ordinary circular rotary motion into any non-circular motion that can be defined as a non-overlapping proper function in polar coordinates are provided. Embodiments disclosed teach how to make and use devices that can use the rotary output from motors, turbines and other sources of circular rotary motion to create motion that follows square, rectangular, triangular, or other useful paths. Such devices can be usefully employed as a replacement for conventional devices in applications where the desired path or area of coverage is not circular, including air-moving (fans), air-energy capture (turbines), surface finishing (sanding, polishing, cleaning), among many others.

Abstract: A data processing system implements receiving a first input in a spreadsheet in a spreadsheet application, detecting an indication that the first input includes first executable program code, analyzing the first executable program code to identify first references to one or more first elements of the spreadsheet in the first executable program code, requesting spreadsheet data associated with the one or more first elements of the spreadsheet from the spreadsheet application, receiving the spreadsheet data from the spreadsheet application; executing the first executable program code using the spreadsheet data referenced in the first executable program code to obtain a first program code result and causing the spreadsheet application to display the first program code result in the spreadsheet application.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Embodiments of positioning systems and methods are disclosed herein. Embodiments of such positioning systems may include a hierarchy of positioning systems. Each of the positioning systems in the hierarchy may be adapted to move each positioning system lower in the hierarchy along with one or more end-effectors. A control system may control the positioning systems of the hierarchy using a control method comprising a coarse step, a refinement step, or an adaptive step.

Abstract: A system for implementing a trial a field is provided. In an embodiment, the system is configured to generate a trial recommendation for a field and, based on field data for the field, compute a yield probabilities for the field. The system is also configured to generate a plurality of outcome-based values for the field based on the yield probabilities, compute crop values for each of the outcome-based values and a bushel per acre value, and cause display of an interface that dynamically displays each of the plurality of outcome-based values for the field based on a selected bushel per acre value. The system is further configured to receive user input changing a position of an interactive sliding widget in the interface, to change the bushel per acre value, and in response, compute a crop value for each of the outcome-based values based on the changed bushel per acre value.

Abstract: Systems and methods for increasing fluidity of a shear-thinning material during transit using an energizer which is coupled to a conveyance and configured to impart energy to the shear-thinning material as it is transported by the conveyance, thereby increasing the fluidity of the Material source Conveyor Form material. The conveyance may comprise any of a wide variety of transport means, including pumps, hoses or other conduits, conveyor belts, bins or buckets, chutes, hoppers, or the like. The energizer may use elements that generate mechanical vibrations, electromagnetic waves, acoustic waves, or the like to transfer energy to the shear-thinning material. The energy-imparting elements may be at a localized portion of the conveyance, or at multiple locations along a transport path of the conveyance, and may be controlled by a controller based on such parameters as sensed characteristics of the shear-thinning material or environmental conditions.

Abstract: Disinfection cap includes housing comprising closed top, essentially cylindrical sidewall, and open bottom formed by the sidewall with opening to inner cavity within the housing for receiving mating feature of needleless connector. Disinfection sponge can be configured within inner cavity, with removable cover sealing opening to inner cavity to seal sponge within inner cavity prior to cap use. Inner cavity includes threads on inner surface of its sidewall that do not correspond to the mating feature of needleless connector. One thread engages with mating feature of needleless connector. Plurality of disinfection caps can be disposed on strip of IV pole hanging device such that each cap can be peeled off the strip unsealed for immediate use, or separated from the strip sealed for later use.

Abstract: The present invention relates to tetrahydroisoquinoline compounds that are KEAP1 binders and their incorporation in bifunctional compounds which are capable of acting as proteolysis-targeting chimeras. The present invention also relates to processes for the preparation of these bifunctional compounds, and to their use in the treatment of diseases or disorders associated with proteins that may be degraded through the KEAP1 E3 ligase.

Abstract: Embodiments of positioning systems and methods are disclosed herein. Embodiments of such positioning systems may include a hierarchy of positioning systems. Each of the positioning systems in the hierarchy may be adapted to move each positioning system lower in the hierarchy along with one or more end-effectors. A control system may control the positioning systems of the hierarchy using a control method comprising a coarse step, a refinement step, or an adaptive step.

Abstract: The present invention involves systems and methods for tether length management between an unmanned aerial vehicle (UAV), e.g., a drone, and a surface vehicle (SV), dynamically moving ground vehicle or an unmanned SV (USV) base station. The tether length control methodology of the present invention allows for a dynamic moving base station and maintains minimal tether tension, while measuring those dynamic oscillations of the UAV and SV. This novel slack tether tension management ultimately reduces forces and power consumption. A key feature of the present invention is the capability to de-couple the UAV's motion from the base/winch/SV. This enables operation in highly dynamic environments, e.g., maritime, moving ground vehicles, etc.

Abstract: A device, including an insertion tool including an insertion guide that is flexible in a direction lying in at least a plane lying on a longitudinal axis thereof, the insertion guide having a slit and/or a gap extending in the longitudinal direction, the plane extending through the slit and/or gap, wherein the guide configured to maintain a pre-curved electrode assembly in a substantially straight configuration while preventing the electrode assembly from twisting in response to stresses induced by bias forces which urge the assembly to return to its pre-curved configuration, when the insertion guide is flexed in the plane.