Abstract: An improved vehicle cargo tailgate enclosure particularly adapted for ease of installation and removal. The tailgate enclosure comprises two side walls and a rear wall. The rear wall is configured to slope upwardly and rearwardly to provide additional storage space to a cargo bed of a vehicle. The cargo tailgate enclosure further comprises tubular members which comprise a non-circular cross section which provide exceptional strength a structural stability to the cargo tailgate enclosure. The cargo tailgate enclosure further comprises a plurality of upright members. Some of the upright members are configured to attach the cargo tailgate enclosure to a vehicle and to cap the tubular members. Other upright members are configured to support the tailgate enclosure against the surface cargo bed or a tailgate of a vehicle.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A method of data transfer from a tenant to a service provider comprises encrypting the data with a public key of a key pair generated by a secure device within the service provider system. The data thus cannot be accessed by the service provider during transmission. The data is generated with a corresponding access control list, which specifies that a valid certificate must be presented in order to grant a particular use of the data once stored. The tenant can thus retain control of the use of the data even though it has been transferred out of the tenant system. A method of controlling use of data securely stored in the service provider system comprises issuing a use certificate having an expiry time to the party requesting use of the data. The use certificate must be validated before use of the stored data is granted. This enables the tenant to grant use of the stored data for a limited time period.

Abstract: A tamper evident cap assembly includes an outer cap having an outer cap end wall and an outer cap skirt, and an inner cap having an inner cap end wall and an inner cap skirt. The inner cap skirt has a thread on an inner surface for selectively fastening the cap assembly on a portion of a container. The thread has separations therein. The first and second vertical ratchet teeth of the outer cap and the inner cap, respectively, abut when the outer cap is turned in an application direction to rotate the inner cap and the outer cap together to fasten the inner cap onto the container. When a downward force is applied on the outer cap, the second end teeth on the inner cap engage with the first end teeth on the outer cap applying torque on the outer cap in the removal direction turning the inner cap to release the cap assembly from the container and rupture the tamper evident band.

Abstract: A retractable step and side bar assembly that can be used for raised vehicles, such as trucks. The retractable step can be configured to provide for significant reach in a deployed position to allow for a user to enter the raised vehicle. Further, in the stowed position the retractable step can be located within the side bar, thereby providing a low profile as well as an enhanced aesthetic appearance.

Abstract: A tailgate enclosure for use with a vehicle can include a plurality of cross-members, a first upright, a second upright, and only one additional upright. Each of the cross-members can be vertically spaced apart from an adjacent one of the cross-members and can include a first beam, a second beam, and a central beam having a first end and a second end, the central beam positioned at least partially between the first and second beams. The first upright can secure the first beam of each of the cross-members to a first sidewall of the vehicle and the second upright can secure the second beam of each of the cross-members to a second sidewall of the vehicle. The additional upright can be positioned along the central beam of each of the cross-members between the first and second ends of the central beam.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A separable footwear article may comprise an outsole oriented at the bottom of the footwear and configured for ground contact, the outsole comprising a first material; an upper portion releasably coupled to the outsole with thread using chain stitching, the upper portion comprising a second material different from the first material; and an insole removeably disposed adjacent the upper portion and the outsole, the insole comprising a third material different from the first material and the second material; wherein the outsole, the upper portion, and insole are capable of being separated by releasing the thread and hand pulling the thread from the footwear article.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.

Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.

Abstract: An improved vehicle cargo tailgate enclosure particularly adapted for ease of installation and removal. The tailgate enclosure comprises two side walls and a rear wall. The rear wall is configured to slope upwardly and rearwardly to provide additional storage space to a cargo bed of a vehicle. The cargo tailgate enclosure further comprises tubular members which comprise a non-circular cross section which provide exceptional strength a structural stability to the cargo tailgate enclosure. The cargo tailgate enclosure further comprises a plurality of upright members. Some of the upright members are configured to attach the cargo tailgate enclosure to a vehicle and to cap the tubular members. Other upright members are configured to support the tailgate enclosure against the surface cargo bed or a tailgate of a vehicle.

Abstract: System and methods for managing apparel are disclosed. One method includes receiving information indicative of an magnetically energized sensor disposed adjacent a fastener associated with an item of apparel; determining a characteristic of the fastener based at least upon the received information; and providing a response to a wearer of the item of apparel based at least upon the characteristic of the fastener.

Abstract: System and methods for managing compliance of a wearer of apparel are disclosed. One method includes receiving an identifier associated with a toe cap for footwear; receiving, via radio frequency, characteristic information associated with the toe cap for footwear; determining a compliance of the toe cap based at least on the identifier and the characteristic information; and providing a response to a wearer of the footwear based at least upon the determination of the compliance.

Abstract: In an example, a computer implemented method can include extracting a plurality of functions from assembly code representative of machine code compiled based on obfuscated source code (e.g., legacy source code), causing one or more functions of the plurality of functions to be grouped based on relationships between the plurality of functions, and defining a class for each grouping of functions. Each defined class can include a subset of functions of the plurality of functions. The method can include causing a diagram model to be generated based on the plurality of classes. The diagram model can characterize the obfuscated source code.

Abstract: A retractable step and side bar assembly that can be used for raised vehicles, such as trucks. The retractable step can be configured to provide for significant reach in a deployed position to allow for a user to enter the raised vehicle. Further, in the stowed position the retractable step can be located within the side bar, thereby providing a low profile as well as an enhanced aesthetic appearance.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: Technologies are generally described for providing a system to facilitate efficient management and prioritization of conversations, such as emails, in a communication application. Conversations may be prioritized according to user preferences, and an inbox may be rearranged to display important conversations in a user defined order. Conversations may also be associated together so that they may appear together and flow together in the inbox. Additionally, the system may enable a user to delay display of a conversation until a later time based on various criteria such as location, time, and client device. A user may also move important emails to the top of an inbox for prominent display. The system may perform the actions automatically based on observed user behavior. Furthermore, the system may enable touch interactions for interacting with and managing the conversations, and quick controls may be provided for executing commands to perform actions associated with the conversations.

Abstract: System and methods for managing comfort of a wearer of apparel are disclosed. One method includes determining a first environmental characteristic using a first sensor disposed adjacent an item of apparel; determining a second environmental characteristic using a second sensor disposed adjacent the item of apparel; determining a comfort signature based at least on the first environmental characteristic and the second environmental characteristic; and providing a response to a wearer of the item of apparel based at least upon the comfort signature.

Abstract: Disclosed herein are embodiments of a convertible sliding top assembly for use with a vehicle. The convertible sliding top assembly can create an opening on the top of the vehicle by rotating a plurality of arms and folding over a soft cover. The assembly can be designed and shaped to improve aerodynamics when the vehicle is moving and prevent the buildup of water on the soft cover.