Patents by Inventor NICHOLAS A. BE

NICHOLAS A. BE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them
    Patent number: 11186548
    Abstract: Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: November 30, 2021
    Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Carlos A. Valdez, Nicholas A. Be, Michael A. Malfatti, Heather Ann Enright, Brian J. Bennion, Timothy S. Carpenter, Saphon Hok, Hio Leong Lao, Tuan H. Nguyen
  • Compounds for reactivation of acetylcholinesterase and related compositions methods and systems
    Patent number: 10590498
    Abstract: Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: March 17, 2020
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos A. Valdez, Nicholas A. Be, Brian Bennion, Tim Carpenter, Heather Ann Enright, Felice Lightstone, Mike Malfatti, Margaret Windy McNerney, Tuan H. Nguyen
  • COMPOUNDS FOR CENTRAL REACTIVATION OF ORGANOPHOSPHORUS- BASED COMPOUND-INHIBITED ACETYLCHOLINESTERASE AND/OR INACTIVATION OF ORGANOPHOSPHORUS-BASED ACETYLCHOLINESTERASE INHIBITORS AND RELATED COMPOSITIONS METHODS AND SYSTEMS FOR MAKING AND USING THEM
    Publication number: 20190152920
    Abstract: Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 23, 2019
    Inventors: Carlos A. Valdez, Nicholas A. Be, Michael A. Malfatti, Heather Ann Enright, Brian J. Bennion, Timothy S. Carpenter, Saphon Hok, Hio leong Lao, Tuan H. Nguyen
  • COMPOUNDS FOR REACTIVATION OF ACETYLCHOLINESTERASE AND RELATED COMPOSITIONS METHODS AND SYSTEMS
    Publication number: 20170335415
    Abstract: Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
    Type: Application
    Filed: May 15, 2017
    Publication date: November 23, 2017
    Inventors: Carlos A. VALDEZ, Nicholas A. BE, Brian BENNION, Tim CARPENTER, Heather Ann ENRIGHT, Felice LIGHTSTONE, Mike MALFATTI, Margaret Windy MCNERNEY, Tuan H. NGUYEN
  • VACCINATION WITH RECOMBINANT MYCOBACTERIUM TUBERCULOSIS PknD ATTENUATES BACTERIAL DISSEMINATION TO THE BRAIN
    Publication number: 20160136255
    Abstract: Vaccines comprising Mycobacterium tuberculosis (M. tuberculosis) PknD sensor polypeptides, compositions, kits, and methods of use for treating central nervous system tuberculosis are disclosed. More specifically, the disclosure provides a method for treating or preventing central nervous system (CNS) tuberculosis (TB) in a subject, the method comprises administering to the subject a therapeutically effective amount of a vaccine comprising an M tuberculosis PknD sensor polypeptide, or an immunogenic fragment for inhibiting or preventing M tuberculosis bacterial invasion of brain microvascular endothelia.
    Type: Application
    Filed: June 6, 2014
    Publication date: May 19, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: SANJAY K. JAIN, CIARAN SKERRY, NICHOLAS A. BE