Patents by Inventor Nicholas A. Cacalano

Nicholas A. Cacalano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human JAK3 variants
    Patent number: 6372898
    Abstract: Muteins are provided, which are mutational variants of human Jak3 proteins. Particular positions of natural proteins are identified as critical in providing various different activities. Specific embodiments demonstrate properties of variations at these positions.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: April 16, 2002
    Assignee: Schering Corporation
    Inventors: Nicholas A. Cacalano, James A. Johnston
  • Derivatives of cyclosporine A, antibodies directed thereto and uses thereof
    Patent number: 5405785
    Abstract: This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reactive group. This invention also provides a composition of matter which comprises a conjugate of a compound and the aforementioned molecule wherein the compound is bound to the molecule through the reactive group. This invention further provides an antibody directed to the aforementioned composition of matter specific for cyclosporine A or congener of cyclosporine A. Finally, this invention provides a method of monitoring levels of cyclosporine A or congener of cyclosporine A in a subject.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: April 11, 1995
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Bernard F. Erlanger, William L. Cleveland, Nicholas A. Cacalano
  • Derivatives of cyclosporina A, antibodies directed thereto and uses thereof
    Patent number: 5350574
    Abstract: This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reactive group. This invention also provides a composition of matter which comprises a conjugate of a compound and the aforementioned molecule wherein the compound is bound to the molecule through the reactive group. This invention further provides an antibody directed to the aforementioned composition of matter specific for cyclosporine A or congener of cyclosporine A. This invention also provides methods for detecting the presence of cyclosporine A or congener thereof, methods for detecting the concentration of cyclosporine A or congener thereof, as well as a method of monitoring levels of cyclosporine A or congener of cyclosporine A in a subject.
    Type: Grant
    Filed: May 13, 1991
    Date of Patent: September 27, 1994
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Bernard F. Erlanger, William L. Cleveland, Nicholas A. Cacalano