Patents by Inventor Nicholas A. Grippi
Nicholas A. Grippi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9283704Abstract: A multilayer evacuated blood collection tube is provided having a first tube layer, and a second tube layer formed on the first tube layer and a closure, the second tube layer being a nanocomposite barrier layer. Such containers include but are not limited to blood collection tubes, evacuated blood collection tubes, centrifuge tubes, culture bottles, and syringe barrels.Type: GrantFiled: August 25, 2010Date of Patent: March 15, 2016Assignee: Becton, Dickinson and CompanyInventors: Brian F. Ahern, Donald J. Carano, Nicholas A. Grippi, Paul R. Soskey, Gregory L. Lusardi
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Publication number: 20150090650Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.Type: ApplicationFiled: August 12, 2014Publication date: April 2, 2015Inventors: Nicholas A. Grippi, Roberto C. Beretta
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Patent number: 8802362Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.Type: GrantFiled: May 18, 2010Date of Patent: August 12, 2014Assignee: Cascade Medical Enterprises, LLCInventors: Nicholas A. Grippi, Roberto C. Beretta
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Publication number: 20130299407Abstract: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also includes a transfer device having a cannula with a first end and a second end. The first and second ends are adapted to puncture the sealed primary and secondary containers in order to provide fluid communication between the first and second containers.Type: ApplicationFiled: July 22, 2013Publication date: November 14, 2013Applicant: CASCADE MEDICAL ENTERPRISES, LLCInventors: Roberto Beretta, Nicholas A. Grippi
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Patent number: 8491564Abstract: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also includes a transfer device having a cannula with a first end and a second end. The first and second ends are adapted to puncture the sealed primary and secondary containers in order to provide fluid communication between the first and second containers.Type: GrantFiled: April 15, 2009Date of Patent: July 23, 2013Assignee: Cascade Medical Enterprises, LLCInventors: Roberto Beretta, Nicholas A. Grippi
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Publication number: 20120156278Abstract: A method of regenerating tissue in a living organism. The method includes the act of contacting an affected area of the living organism with a solid-fibrin web, the solid-fibrin web comprising platelets that release growth factors about one minute after contact to regenerate the tissue in the living organism.Type: ApplicationFiled: December 19, 2011Publication date: June 21, 2012Applicant: Cascade Medical Enterprises, LLCInventors: Roberto Beretta, Nicholas A. Grippi
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Publication number: 20110123414Abstract: A multilayer evacuated blood collection tube is provided having a first tube layer, and a second tube layer formed on the first tube layer and a closure, the second tube layer being a nanocomposite barrier layer. Such containers include but are not limited to blood collection tubes, evacuated blood collection tubes, centrifuge tubes, culture bottles, and syringe barrels.Type: ApplicationFiled: August 25, 2010Publication date: May 26, 2011Applicant: BECTON, DICKINSON AND COMPANYInventors: Brian F. Ahern, Donald J. Carano, Nicholas A. Grippi, Paul R. Soskey, Gregory L. Lusardi
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Publication number: 20110020196Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.Type: ApplicationFiled: May 18, 2010Publication date: January 27, 2011Inventors: Nicholas A. Grippi, Roberto C. Beretta
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Patent number: 7803305Abstract: A co-injection process is provided for fabricating improved multi-layer containers, including but not limited to blood collection tubes, evacuated blood collection tubes, culture bottles, centrifuges tubes, and syringe barrels. The container includes a tube (10) having a bottom wall (12) and a side wall (14) with an open end (18). The container can be provided with a stopper having an upper portion (22) and a skirt with an outside portion (30), a well (34) and a cavity (36). The tube and stopper assembly can be used for medical purposes including containing a blood sample within an enclosed interior space (40).Type: GrantFiled: June 14, 2002Date of Patent: September 28, 2010Assignee: Becton, Dickinson and CompanyInventors: Brian F. Ahern, Nicholas A. Grippi, Paul R. Soskey, Donald J. Carano, Norman J. Hutton, Danielle M. DeSalvo, Gregory L. Lusardi
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Patent number: 7745106Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.Type: GrantFiled: June 26, 2003Date of Patent: June 29, 2010Assignee: Cascade Medical Enterprises, LLCInventors: Roberto C. Beretta, Nicholas A. Grippi
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Publication number: 20090281516Abstract: A multilayer evacuated blood collection tube is provided having a first tube layer, and a second tube layer formed on the first tube layer and a closure, the second tube layer being a nanocomposite barrier layer. Such containers include but are not limited to blood collection tubes, evacuated blood collection tubes, centrifuge tubes, culture bottles, and syringe barrels.Type: ApplicationFiled: November 13, 2008Publication date: November 12, 2009Applicant: BECTON, DICKINSON AND COMPANYInventors: Brian F. Ahern, Nicholas A. Grippi, Paul R. Soskey, Donald J. Carano, Norman J. Hutton, Danielle M. Desalvo, Gregory L. Lusardi
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Publication number: 20090258056Abstract: A method of regenerating tissue in a living organism. The method includes the act of contacting an affected area of the living organism with a solid-fibrin web, the solid-fibrin web comprising platelets that release growth factors about one minute after contact to regenerate the tissue in the living organism.Type: ApplicationFiled: April 14, 2009Publication date: October 15, 2009Applicant: CASCADE MEDICAL ENTERPRISES, LLCInventors: Roberto Beretta, Nicholas A. Grippi
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Publication number: 20090203613Abstract: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also includes a transfer device having a cannula with a first end and a second end. The first and second ends are adapted to puncture the sealed primary and secondary containers in order to provide fluid communication between the first and second containers.Type: ApplicationFiled: April 15, 2009Publication date: August 13, 2009Applicant: CASCADE MEDICAL ENTERPRISES, LLCInventors: Roberto Beretta, Nicholas A. Grippi
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Publication number: 20080199513Abstract: A method of regenerating tissue in a living organism. The method includes the act of contacting an affected area of the living organism with a solid-fibrin web, the solid-fibrin web comprising platelets that release growth factors about one minute after contact to regenerate the tissue in the living organism.Type: ApplicationFiled: February 15, 2008Publication date: August 21, 2008Applicant: CASCADE MEDICAL ENTERPRISES, LLCInventors: Roberto Beretta, Nicholas A. Grippi
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Publication number: 20080190857Abstract: An apparatus and method of forming a solid-fibrin web. The apparatus includes a centrifuge (600) having a housing (604), and actuator (648), a wheel (660), and a flange (664). The housing includes a recessed area (616) and a base (608) supportable on a surface. The wheel is coupled to the actuator and extends into the recessed area and is adapted to contact a first end of a container (620). The flange extends into the recessed area opposite the wheel and defines an adjustable distance between the wheel and the flange. The flange is adapted to contact a second end of the container and the actuator is operable to rotate the container. The container is oriented substantially parallel with respect to the base.Type: ApplicationFiled: March 22, 2006Publication date: August 14, 2008Applicant: CASCADE MEDICAL ENTRPRISES, LLCInventors: Roberto Beretta, Nicholas A. Grippi
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Publication number: 20060074394Abstract: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends are capable of puncturing the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container is capable of blocking flow through the cannula upon entering therein.Type: ApplicationFiled: November 22, 2005Publication date: April 6, 2006Applicants: Cascade Medical Enterprises, LLC, Roberto BerettaInventors: Roberto Beretta, Nicholas Grippi
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Patent number: 6979307Abstract: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium separates red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends puncture the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container blocks flow through the cannula upon entering therein.Type: GrantFiled: January 15, 2002Date of Patent: December 27, 2005Assignees: Cascade Medical Enterprises LLCInventors: Roberto Beretta, Nicholas A. Grippi
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Publication number: 20050037165Abstract: A co-injection process is provided for fabricating improved multi-layer containers, including but not limited to blood collection tubes, evacuated blood collection tubes, culture bottles, centrifuges tubes, and syringe barrels. The container includes a tube (10) having a bottom wall (12) and a side wall (14) with an open end (18). The container can be provided with a stopper having an upper portion (22) and a skirt with an outside portion (30), a well (34) and a cavity (36). The tube and stopper assembly can be used for medical purposes including containing a blood sample within an enclosed interior space (40).Type: ApplicationFiled: June 14, 2002Publication date: February 17, 2005Inventors: Brian Ahern, Nicholas Grippi, Paul Soskey, Donald Carano, Norman Hutton, Danielle DeSalvo, Gregory Lusardi
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Publication number: 20040071786Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.Type: ApplicationFiled: June 26, 2003Publication date: April 15, 2004Inventors: Nicholas A. Grippi, Roberto C. Beretta
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Patent number: 6506573Abstract: An additive formulation comprising heparinase and trehalose, a method for using the formulation and a device containing the formulation. The additive formulation is useful in substantially neutralizing residual heparin from a blood sample when used in a blood collection tube without interfering with the clinical analysis of the blood sample.Type: GrantFiled: June 26, 2002Date of Patent: January 14, 2003Assignee: Becton Dickinson and CompanyInventors: Antoinette F. Antignani, Emy Cheng, Jeffrey M. Evans, Nicholas A. Grippi, Bryan S. Wong