Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end to a distal end, a proximal release wire, and a distal release wire. The proximal release wire may extend distally from a proximal end configured to remain outside the body to a distal end and may be slidably disposed within the lumen of the elongate shaft. The distal release wire may extend distally from a proximal end to a distal end and may be slidably disposed within the lumen of the elongate shaft. The proximal end of the distal release wire may be slidably coupled to the distal end of the proximal release wire. The distal release wire may be configured to releasably attach a medical device to the distal end of the elongate shaft.

Abstract: A contact includes a cantilever beam and a protection tab. The cantilever beam extends from a beam connected end to a beam free end along an insertion direction. The protection tab extends from a tab connected end to a tab free end in a direction opposite to the insertion direction. The tab free end is positioned adjacent to the beam free end.

Abstract: A medical device for left atrial appendage closure includes a support frame with a proximal collar and a distal collar, where the support frame is actuatable from a first constrained configuration to a second radially expanded configuration. A membrane is disposed on at least a portion of the support frame, and an engagement element is coupled to the distal end region of the support frame. The engagement element extends distally from the support frame and is configured to engage an inner surface of the left atrial appendage and prevent the support frame from sliding along the inner surface of the left atrial appendage during implantation.

Abstract: The present disclosure relates to an injection device, in particular a micro dose injection device such as, for example, an ophthalmic injection device. An example device comprises a rotatable plunger; a solution receptacle having a first end configured to slidably receive the rotatable plunger and a second end configured to dispense solution contained in the solution receptacle; a first stop member configured to prevent the rotatable plunger from being slidably displaced to a second position while the rotatable plunger is at a first position and in a first orientation; and a second stop member configured to prevent the rotatable plunger from rotating in a first direction about the first axis while the rotatable plunger is at the first position and in the first orientation, wherein slidably displacing the rotatable plunger from the first position to the second position dispenses a quantity of the solution contained in the solution receptacle.

Abstract: An injection device (10) comprises an injection solution receptacle (30) and a plunger (70) at least a portion of which is slidably received in the injection solution receptacle (30), wherein the plunger (70) is displaceable relative to the injection solution receptacle (30) in a distal direction in order to expel an injection solution contained in the injection solution receptacle (30) from the injection solution receptacle (30). A first plunger stop mechanism (140) is adapted to stop a displacement of the plunger (70) relative to the injection solution receptacle (30) in the distal direction at a first dosing position (P1).

Abstract: An optical assembly includes an optical ferrule configured to receive light from an optical waveguide and including at least four ferrule alignment features; and a cradle securing the optical ferrule therein and configured to align the optical ferrule to an optical component, the cradle including at least four cradle alignment features configured to make contact or near contact with the at least four ferrule alignment features in a one to one correspondence in at least four corresponding contact regions, such that as a temperature of at least one of the cradle and the optical ferrule changes sufficiently, the corresponding alignment features of the optical ferrule and the cradle slide relative to each other causing the corresponding alignment features of the optical ferrule and the cradle to move to define corresponding traversed regions, such that when extended, the traversed regions of the at least four ferrule alignment features and the at least four cradle alignment features pass within 20 microns of a sa

Abstract: Embodiments are directed to methods, systems, and apparatuses, for providing fittings capable of being orbitally welded. A system may include measuring components configured to measure a tubing thickness and measure a fitting thickness. The system may also include a processor configured to determine a difference in thickness between the measured tubing thickness and the measured fitting thickness and, based on the determined difference in thickness, determine an amount of fitting that is to be removed to reach a set, specified thickness that allows the fitting to be orbitally welded. The system may also include a facing tool configured to bevel and shape an end portion of the fitting according to the determined amount of fitting that is to be removed to reach the specified thickness and may include an orbital welder configured to orbitally weld the beveled end of the fitting to the tubing in a fusion socket weld.

Abstract: An example medical device for occluding the left atrial appendage is disclosed. The example medical device for occluding the left atrial appendage includes an expandable member having a first end region and a second end region. The expandable member comprises at least one inflation cavity and at least one valve member configured to selectively seal the inflation cavity. A first inflation media may be disposed within the at least one inflation cavity and a second inflation media may be disposed within the at least one inflation cavity. The second inflation media may be different from the first inflation media. The expandable member may be configured to expand and seal the opening of the left atrial appendage.

Abstract: Embolic material delivery devices and methods of using them are disclosed. An example embolic material delivery assembly includes an outer member having a lumen extending therein and a distal end region, an inner member disposed within the lumen of the outer member, wherein the inner member includes a first lumen extending therein. The embolic material delivery assembly also includes a first embolic material extending within the first lumen of the inner member, the embolic material having a first distal end region. The embolic material delivery assembly also includes an anchor disposed within the lumen of the outer member, the anchor having a first attachment region. Further, the first distal end region of the first embolic material is coupled to the first attachment region of the anchor.

Abstract: An attachment mechanism for a medical implant system may include a first part fixedly attached to a distal end of an elongate shaft, the first part having a first longitudinal lumen configured to slidably receive a release wire disposed within the elongate shaft, and a second part fixedly attached to a proximal end of a medical implant, the second part having a second longitudinal lumen configured to slidably receive the release wire. A tubular distal portion of the second part may include an engagement feature configured to non-releasably engage the second part with the medical implant.

Abstract: A method of manufacturing an elongate shaft for delivery of a medical device may include disposing a polymeric sheath having a lumen extending therethrough over a mandrel; sliding a proximal portion of the polymeric sheath into a lumen of a metallic tubular member; placing a polymeric tubular member over the distal portion of the polymeric sheath and a distal portion of the metallic tubular member; fixedly attaching a proximal coupler to a distal end of a longitudinal support filament; inserting a proximal end of the longitudinal support filament between the polymeric sheath and the polymeric tubular member to position the longitudinal support filament alongside the distal portion of the metallic tubular member and a distal portion of the polymeric sheath; and reflowing the polymeric tubular member to secure the longitudinal support filament relative to the polymeric sheath and the metallic tubular member.

Abstract: A vascular occlusion device for deployment within a lumen of a vessel may include a self-expanding frame configured to shift between a collapsed configuration and an expanded configuration, the self-expanding frame defining a perimeter of an interior space disposed within the self-expanding frame, and an occlusive membrane secured to the self-expanding frame. The occlusive membrane may include a suspended portion disposed within the self-expanding frame and spaced apart from the perimeter of the interior space.

Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end to a distal end, a release wire disposed within the lumen of the elongate shaft configured to releasably attach a medical device to the distal end of the elongate shaft, and a securement member releasably coupled to the proximal end of the elongate shaft and fixedly attached to a proximal end of the release wire. A proximal portion of the securement member may be configured to translate proximally away from the proximal end of the elongate shaft upon application of a proximally-directed force to the proximal portion of the securement member and radially inward directed force to the distal portion of the securement member while the elongate shaft is maintained in a fixed position.

Abstract: Systems and methods are provided for simulating an integrated circuit system. A file representative of an integrated circuit layout is received, the integrated circuit layout including a plurality of cells and characteristics of power supply and ground paths to each cell. A vulnerable cell of the integrated circuit layout based on a vulnerability characteristic of the vulnerable cell. A power analysis of a portion of the integrated circuit layout is performed to determine a plurality of power and ground levels within a timing window for each of a plurality of cells including the vulnerable cell. A timing analysis of the vulnerable cell is performed, where the timing analysis receives a single power level and single ground level for the vulnerable cell and determines a slack level for the vulnerable cell. An at risk path is identified based on the vulnerable cell slack level, and a dynamic power/ground simulation of one or more cells in the at risk path is performed.

Abstract: An optical assembly includes an optical ferrule including a light redirecting member configured to receive light from an optical waveguide along a first direction and redirect the light along a different second direction, the redirected light exiting the optical ferrule at an exit location on a mating surface of the optical ferrule, and a cradle with a mating surface and configured to hold and align the optical ferrule to an optical component, wherein the mating surface of the optical ferrule and the mating surface of the cradle are held together by a magnetic attraction between opposing magnetic elements, wherein the optical ferrule and the cradle, but not the opposing elements, physically contact each other.

Abstract: A vascular occlusion system may include a microcatheter configured to navigate a vasculature, an elongate shaft slidably disposed within a lumen of the microcatheter, the elongate shaft having a lumen extending from a proximal end of the elongate shaft to a distal end of the elongate shaft, a plurality of occlusive medical devices releasably connected to the elongate shaft, and a release wire slidably disposed within the elongate shaft and at least a portion of each of the plurality of occlusive medical devices. The release wire secures each of the plurality of occlusive medical devices to the distal end of the elongate shaft when the release wire is disposed within at least a portion of each of the plurality of occlusive medical devices.

Abstract: A connector assembly which controls impedance. The connector assembly includes a first metallic outer housing and a second metallic outer housing. The second metallic housing has a conductor receiving portion. A rib is formed in the conductor receiving portion, the rib extends in a direction which is parallel to a longitudinal axis of the second metallic outer shell. A terminal positioned in the connector assembly has a conductor receiving section and a mating terminal receiving section. The mating terminal receiving section has a lead-in portion and securing projections. At least one longitudinally extending opening is positioned about the circumference of the mating terminal receiving section, the opening reduces the cross section of the terminal. The opening provides impedance tuning to allow for a defined pitch of the terminal to be maintained without an impedance drop because of the close proximity of the terminal to an adjacent terminal.

Abstract: Provided is an indirect heated separation assembly that includes a vessel assembly having a heating section and a separation section, a wall separating the heating section from the separation section, the wall configured to be heated by a heating fluid in the heating section to provide indirect heat to the separation section, and a coil assembly at least partially disposed in the heating section, the coil assembly including an inlet configured to receive a process fluid and an outlet in communication with an inlet of the separation section to direct the process fluid after heating to the separation section.

Abstract: Provided is an indirect heated separation assembly that includes a vessel having a heating section and a separation section, a plate separating the heating section from the separation section, the plate being configured to be heated by a heating fluid in the heating section to provide indirect heat to the separation section, and a coil assembly disposed in the heating section, the coil assembly including an inlet configured to receive a process fluid and an outlet in communication with an inlet of the separation section to direct the process fluid after heating to the separation section.