Patents by Inventor NICHOLAS A. WILLIS

NICHOLAS A. WILLIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for characterizing a DNA repair variant polypeptide
    Patent number: 10697026
    Abstract: As described below, the present invention provides quantitative homologous recombination assays developed to characterize the pathogenicity DNA repair polypeptides (e.g., BRCA1, BRCA2, Rad51) and provide urgently needed functional information on the significance of DNA repair variants of uncertain significance (VUS) alleles. The invention also provides a method of generating site-specific recombination at a genomic locus or site-specific genome editing by inhibiting replication at the genomic locus, e.g., involving contacting the genomic locus with polypeptides that specifically bind target sequences at the genomic locus.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: June 30, 2020
    Assignee: BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Ralph Scully, Nicholas A. Willis
  • COMPOSITIONS AND METHODS FOR CHARACTERIZING A DNA REPAIR VARIANT POLYPEPTIDE
    Publication number: 20190002990
    Abstract: As described below, the present invention provides quantitative homologous recombination assays developed to characterize the pathogenicity DNA repair polypeptides (e.g., BRCA1, BRCA2, Rad51) and provide urgently needed functional information on the significance of DNA repair variants of uncertain significance (VUS) alleles. The invention also provides a method of generating site-specific recombination at a genomic locus or site-specific genome editing by inhibiting replication at the genomic locus, e.g., involving contacting the genomic locus with polypeptides that specifically bind target sequences at the genomic locus.
    Type: Application
    Filed: July 6, 2018
    Publication date: January 3, 2019
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Ralph Scully, Nicholas A. Willis
  • Compositions and methods for characterizing a DNA repair variant polypeptide
    Patent number: 10017825
    Abstract: As described below, the present invention provides quantitative homologous recombination assays developed to characterize the pathogenicity DNA repair polypeptides (e.g., BRCA1, BRCA2, Rad51) and provide urgently needed functional information on the significance of DNA repair variants of uncertain significance (VUS) alleles. The invention also provides a method of generating site-specific recombination at a genomic locus or site-specific genome editing by inhibiting replication at the genomic locus, e.g., involving contacting the genomic locus with polypeptides that specifically bind target sequences at the genomic locus.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: July 10, 2018
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Ralph Scully, Nicholas A. Willis
  • COMPOSITIONS AND METHODS FOR CHARACTERIZING A DNA REPAIR VARIANT POLYPEPTIDE
    Publication number: 20160160291
    Abstract: As described below, the present invention provides quantitative homologous recombination assays developed to characterize the pathogenicity DNA repair polypeptides (e.g., BRCA1, BRCA2, Rad51) and provide urgently needed functional information on the significance of DNA repair variants of uncertain significance (VUS) alleles. The invention also provides a method of generating site-specific recombination at a genomic locus or site-specific genome editing by inhibiting replication at the genomic locus, e.g., involving contacting the genomic locus with polypeptides that specifically bind target sequences at the genomic locus.
    Type: Application
    Filed: November 16, 2015
    Publication date: June 9, 2016
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: RALPH SCULLY, NICHOLAS A. WILLIS