Patents by Inventor Nicholas Alexander Melosh
Nicholas Alexander Melosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220365015Abstract: A multi-analyte sensor device is disclosed. The multi-analyte device is a handheld device that includes a replaceable sensor. In one embodiment, the replaceable sensor includes a plurality of electrodes coated with one or more different molecular imprinted polymer (MIP) coatings for measuring concentrations of target analytes. The replaceable sensor is configured to be attached or detached from the device one or more times.Type: ApplicationFiled: May 17, 2021Publication date: November 17, 2022Inventors: Nicholas Alexander Melosh, Marc Daniel Ferro, Benjamin Roth Lowenstein, Paul Michael Litvak
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Publication number: 20220155292Abstract: A multi-analyte sensor includes a body having a proximal end and a distal end. A plurality of strips is connected to one end of the body and a plurality of electrical conductors run through the body and into the plurality of strips. Exposed portions of first and second electrical conductors running through first and second strips are coated with analyte-responsive materials, such as a first molecular imprinted polymer (MIP) and a second MIP, respectively. The first MIP has binding sites for a first target analyte and the second MIP has binding sites for a second target analyte. The multi-analyte sensor may be part of a sensing device that also includes a controller and a data store.Type: ApplicationFiled: February 1, 2022Publication date: May 19, 2022Inventors: Nicholas Alexander Melosh, Marc Daniel Ferro, Benjamin Roth Lowenstein, Paul Michael Litvak
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Patent number: 11255853Abstract: A multi-analyte sensor includes a body having a proximal end and a distal end. A plurality of strips is connected to one end of the body and a plurality of electrical conductors run through the body and into the plurality of strips. Exposed portions of first and second electrical conductors running through first and second strips are coated with analyte-responsive materials, such as a first molecular imprinted polymer (MIP) and a second MIP, respectively. The first MIP has binding sites for a first target analyte and the second MIP has binding sites for a second target analyte. The multi-analyte sensor may be part of a sensing device that also includes a controller and a data store.Type: GrantFiled: September 24, 2020Date of Patent: February 22, 2022Assignee: Rhythmic Health, Inc.Inventors: Nicholas Alexander Melosh, Marc Daniel Ferro, Benjamin Roth Lowenstein, Paul Michael Litvak
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Publication number: 20220002555Abstract: This disclosure enables the generation and patterning of color centers with nanometer-scale spatial control in a variety of materials in repeatable fashion and without the use of radiation. Embodiments in accordance with the present disclosure employ a layer of vacancy-injection material disposed on a host-material, where the vacancy-injection material forms a compound with host-material atoms at elevated temperatures. During compound formation, lattice vacancies are generated in the host material and diffuse within the substrate lattice to bond with impurity atoms, thereby forming color centers. High-resolution lithographic patterning of the vacancy-injection film and the short diffusion lengths of the lattice vacancies enables nanometer-level spatial control over the lateral positions of the color centers. Furthermore, the depth of the color centers in the substrate can be controlled by controlling the coating material, thickness, anneal time, and anneal temperature.Type: ApplicationFiled: October 30, 2019Publication date: January 6, 2022Inventors: Nicholas Alexander MELOSH, Matthew A. GEBBIE, Patrick MCQUADE, Andrew E. GONZALEZ
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Patent number: 10581003Abstract: Methods for patterning highly sensitive materials, such as organic materials, organic semiconductors, biomolecular materials, and the like, with photolithographic resolution are disclosed. In some embodiments, a germanium mask (304) is formed on the surface of the sensitive material (302), thereby protecting it from subsequent processes that employ harsh chemicals that would otherwise destroy the sensitive material (302). A microlithography mask (306) is patterned on the germanium mask layer (304), after which the germanium exposed by the microlithography mask (306) is removed by dissolving it in water. After transferring the pattern of the germanium mask (304) into the sensitive material (302), the germanium and microlithography masks (304, 306) are completely removed by immersing the substrate in water, which dissolves the remaining germanium and lifts off the microlithography mask material.Type: GrantFiled: September 1, 2017Date of Patent: March 3, 2020Assignee: The Board of Trustee of the Leland Stanford Junior UniverstiyInventors: Nicholas Alexander Melosh, Matt R. Angle, Mina-elraheb S. Hanna, Yifan Kong
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Patent number: 10426362Abstract: A probe suitable for deep-brain recording and stimulation is provided. The probe comprises a wire bundle that includes a plurality of wires, an integrated circuit having a plurality of electrodes, and an interposer that joins the wire bundle and the integrated circuit such that each of the plurality of electrodes is electrically connected with a different wire of the plurality of wires.Type: GrantFiled: November 10, 2015Date of Patent: October 1, 2019Assignees: The Board of Trustees of the Leland Stanford Junior University, THE FRANCIS CRICK INSTITUTEInventors: Nicholas Alexander Melosh, Matt R. Angle, Jun Ding, Andreas Schaefer, Mina-elraheb S. Hanna
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Publication number: 20190198785Abstract: Methods for patterning highly sensitive materials, such as organic materials, organic semiconductors, biomolecular materials, and the like, with photolithographic resolution are disclosed. In some embodiments, a germanium mask (304) is formed on the surface of the sensitive material (302), thereby protecting it from subsequent processes that employ harsh chemicals that would otherwise destroy the sensitive material (302). A microlithography mask (306) is patterned on the germanium mask layer (304), after which the germanium exposed by the microlithography mask (306) is removed by dissolving it in water. After transferring the pattern of the germanium mask (304) into the sensitive material (302), the germanium and microlithography masks (304, 306) are completely removed by immersing the substrate in water, which dissolves the remaining germanium and lifts off the microlithography mask material.Type: ApplicationFiled: September 1, 2017Publication date: June 27, 2019Inventors: Nicholas Alexander Melosh, Matt R. Angle, Mina-elraheb S. Hanna, Yifan Kong
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Patent number: 10036093Abstract: A solid-state PEC includes mixed ionic and electronic conducting oxides that allow it to operate at temperatures significantly above ambient utilizing both the light and thermal energy available from concentrated sunlight to dissociate water vapor. The solid-state PEC has a semiconductor light absorber coated with a thin MIEC oxide for improved catalytic activity, electrochemical stability and ionic conduction, which is located between the gas phase and the semiconductor light absorber. As a result, the MIEC oxide provides a facile path for minority carriers to reach the water vapor as well as a path for the ionic carriers to reach the solid electrolyte. Elevated temperature operation allows reasonable band misalignments at the interfaces to be overcome, reduces the required overpotential, and facilitates rapid product diffusion away from the surface.Type: GrantFiled: August 20, 2014Date of Patent: July 31, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: William C. Chueh, Nicholas Alexander Melosh, Xiaofei Ye
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Patent number: 9856448Abstract: Nanoscale probes for forming stable, non-destructive seals with cell membranes. The probes, systems including these probes, and methods of fabricating and using the probes described herein may be used to sense from, stimulate, modify, or otherwise effect individual cells or groups of cells. In particular, described herein are nanoscale cellular probes that may be used to fuse with, and in some variations span, the lipid membrane of a cell to provide stable and long lasting contact to the cell. Thus, the probes described herein may be used as part of a system, method or device that would benefit from stable, non-destructive access to and across a cell membrane. In some variations the nanoscale probe devices or systems described herein may be used as part of a drug screening procedure.Type: GrantFiled: August 15, 2014Date of Patent: January 2, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UnivesityInventors: Nicholas Alexander Melosh, Piyush Verma, Benjamin David Almquist
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Publication number: 20160128588Abstract: A probe suitable for deep-brain recording and stimulation is provided. The probe comprises a wire bundle that includes a plurality of wires, an integrated circuit having a plurality of electrodes, and an interposer that joins the wire bundle and the integrated circuit such that each of the plurality of electrodes is electrically connected with a different wire of the plurality of wires.Type: ApplicationFiled: November 10, 2015Publication date: May 12, 2016Applicant: THE FRANCIS CRICK INSTITUTEInventors: Nicholas Alexander Melosh, Matt R. Angle, Jun Ding, Andreas Schaefer, Mina-elraheb S. Hanna
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Publication number: 20150053568Abstract: A solid-state PEC includes mixed ionic and electronic conducting oxides that allow it to operate at temperatures significantly above ambient utilizing both the light and thermal energy available from concentrated sunlight to dissociate water vapor. The solid-state PEC has a semiconductor light absorber coated with a thin MIEC oxide for improved catalytic activity, electrochemical stability and ionic conduction, which is located between the gas phase and the semiconductor light absorber. As a result, the MIEC oxide provides a facile path for minority carriers to reach the water vapor as well as a path for the ionic carriers to reach the solid electrolyte. Elevated temperature operation allows reasonable band misalignments at the interfaces to be overcome, reduces the required overpotential, and facilitates rapid product diffusion away from the surface.Type: ApplicationFiled: August 20, 2014Publication date: February 26, 2015Inventors: William C. Chueh, Nicholas Alexander Melosh, Xiaofei Ye
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Publication number: 20140353172Abstract: Nanoscale probes for forming stable, non-destructive seals with cell membranes. The probes, systems including these probes, and methods of fabricating and using the probes described herein may be used to sense from, stimulate, modify, or otherwise effect individual cells or groups of cells. In particular, described herein are nanoscale cellular probes that may be used to fuse with, and in some variations span, the lipid membrane of a cell to provide stable and long lasting contact to the cell. Thus, the probes described herein may be used as part of a system, method or device that would benefit from stable, non-destructive access to and across a cell membrane. In some variations the nanoscale probe devices or systems described herein may be used as part of a drug screening procedure.Type: ApplicationFiled: August 15, 2014Publication date: December 4, 2014Inventors: Nicholas Alexander MELOSH, Piyush VERMA, Benjamin David ALMQUIST
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Patent number: 8808516Abstract: Nanoscale probes for forming stable, non-destructive seals with cell membranes. The probes, systems including these probes, and methods of fabricating and using the probes described herein may be used to sense from, stimulate, modify, or otherwise effect individual cells or groups of cells. In particular, described herein are nanoscale cellular probes that may be used to span the lipid membrane of a cell to provide stable and long lasting access to the internal cellular structures. Thus, the probes described herein may be used as part of a system, method or device that would benefit from stable, non-destructive access across a cell membrane. In some variations the nanoscale probe devices or systems described herein may be used as part of a drug screening procedure.Type: GrantFiled: March 5, 2012Date of Patent: August 19, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Nicholas Alexander Melosh, Piyush Verma, Benjamin David Almquist
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Publication number: 20120222970Abstract: Nanoscale probes for forming stable, non-destructive seals with cell membranes. The probes, systems including these probes, and methods of fabricating and using the probes described herein may be used to sense from, stimulate, modify, or otherwise effect individual cells or groups of cells. In particular, described herein are nanoscale cellular probes that may be used to span the lipid membrane of a cell to provide stable and long lasting access to the internal cellular structures. Thus, the probes described herein may be used as part of a system, method or device that would benefit from stable, non-destructive access across a cell membrane. In some variations the nanoscale probe devices or systems described herein may be used as part of a drug screening procedure.Type: ApplicationFiled: March 5, 2012Publication date: September 6, 2012Inventors: Nicholas Alexander Melosh, Piyush Verma, Benjamin David Almquist