Abstract: Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (Cmax) of at least about 0.25 ?g/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.

Abstract: A thermostatic mixing valve for hot and cold water has two-stage inlet chambers for the hot and cold water flows respectively. The inlet chambers distribute the flows uniformly with respect to porting for admitting the flows to the mixing chamber to reduce asymmetric flow patterns and promote thorough mixing of the flows within the mixing chamber.

Abstract: A thermostatic mixer for hot and cold water has a shuttle vale movable between a hot seat and a cold seat for controlling the relative proportions of mixed hot and cold water flowing past a thermostat responsive to the mixed water temperature for controlling the shuttle valve in accordance with user selection of the mixed water temperature. Apertures downstream of the hot water seat divert a portion of the hot water flow away from the thermostat so that the thermostat resides in mixed water that is slightly cooler than the mixed water temperature at the outlet. The diverted flow is responsive to changes in pressure of the supplies such that the change in water temperature arising at the thermostat adds to the temperature change caused by the pressure change whereby the response of the thermostat to adjust the shuttle valve to maintain the selected mixed water temperature is enhanced.