Patents by Inventor Nicholas Bell
Nicholas Bell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12584883Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.Type: GrantFiled: March 24, 2021Date of Patent: March 24, 2026Assignee: Cambridge Enterprise LimitedInventors: Ulrich Keyser, Nicholas Bell, Tim Liedl, Marc Ablay, Caterina Ducati
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Patent number: 11202589Abstract: A system and method for assessing blood flow include: an ocular lens; a light source; a digital video camera; a biosensor; a trigger; and a computer. The ocular lens is for viewing a fundus of an eye. The light source is for illuminating the fundus. The digital video camera is for imaging the fundus. The biosensor is for sensing a pulse waveform. The computer is configured for: recording input frames and pulse waveform data in response to an input from the trigger; defining a low-pass frequency and a high-pass frequency from the pulse waveform data; stabilizing the input frames; enhancing contrast of the input frames; separating the input frames into sub-channels; conducting eulerian video magnification for color amplification using the inputs of image sampling rate, the low-pass frequency, the high-pass frequency, and an amplification factor; reconstructing the sub-channels into output frames; and combining the output frames with the input frames.Type: GrantFiled: November 30, 2018Date of Patent: December 21, 2021Assignee: University of Kentucky Research FoundationInventors: Romulo Albuquerque, Nicholas Bell, Paras Vora
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Publication number: 20210341421Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.Type: ApplicationFiled: March 24, 2021Publication date: November 4, 2021Inventors: Ulrich KEYSER, Nicholas BELL, Tim LIEDL, Marc ABLAY, Caterina DUCATI
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Patent number: 10983091Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.Type: GrantFiled: May 6, 2019Date of Patent: April 20, 2021Assignee: Cambridge Enterprise LimitedInventors: Ulrich Keyser, Nicholas Bell, Tim Liedl, Marc Ablay, Caterina Ducati
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Publication number: 20190265194Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.Type: ApplicationFiled: May 6, 2019Publication date: August 29, 2019Inventors: Ulrich KEYSER, Nicholas BELL, Tim LIEDL, Marc ABLAY, Caterina DUCATI
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Patent number: 10330639Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.Type: GrantFiled: December 6, 2012Date of Patent: June 25, 2019Assignee: CAMBRIDGE ENTERPRISE LIMITEDInventors: Ulrich Keyser, Nicholas Bell, Tim Liedl, Marc Ablay, Caterina Ducati
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Publication number: 20190159707Abstract: A system and method for assessing blood flow include: an ocular lens; a light source; a digital video camera; a biosensor; a trigger; and a computer. The ocular lens is for viewing a fundus of an eye. The light source is for illuminating the fundus. The digital video camera is for imaging the fundus. The biosensor is for sensing a pulse waveform. The computer is configured for: recording input frames and pulse waveform data in response to an input from the trigger; defining a low-pass frequency and a high-pass frequency from the pulse waveform data; stabilizing the input frames; enhancing contrast of the input frames; separating the input frames into sub-channels; conducting eulerian video magnification for color amplification using the inputs of image sampling rate, the low-pass frequency, the high-pass frequency, and an amplification factor; reconstructing the sub-channels into output frames; and combining the output frames with the input frames.Type: ApplicationFiled: November 30, 2018Publication date: May 30, 2019Inventors: Romulo Albuquerque, Nicholas Bell, Paras Vora
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Publication number: 20140291153Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.Type: ApplicationFiled: December 6, 2012Publication date: October 2, 2014Inventors: Ulrich Keyser, Nicholas Bell, Tim Liedl, Marc Ablay, Caterina Ducati
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Patent number: 7399985Abstract: A detection system for determining material level in a container where the container has an opening and an optical window mounted to the opening. A sensor element is mounted to the container adjacent the window. The sensor element has an optical emitter and an optical receiver positioned to form a triangular vertex with the material surface level within the container.Type: GrantFiled: July 13, 2006Date of Patent: July 15, 2008Assignee: DataOnline, L.L.C.Inventors: Walter Mruk, Martin Adams, William Kilkerr, Nicholas Bell, Robert Barnacle
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Publication number: 20080011970Abstract: A detection system for determining material level in a container where the container has an opening and an optical window mounted to the opening. A sensor element is mounted to the container adjacent the window. The sensor element has an optical emitter and an optical receiver positioned to form a triangular vertex with the material surface level within the container.Type: ApplicationFiled: July 13, 2006Publication date: January 17, 2008Applicant: DATAONLINE, L.L.C.Inventors: Walter MRUK, Martin ADAMS, William KILKERR, Nicholas BELL, Robert BARNACLE
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Publication number: 20070129268Abstract: A lubricating oil composition is provided containing one or more hydrocarbyl-substituted aromatic lubricant base oils in combination with (a) one or more phenyl-naphthylamines, and (b) one or more diphenyl amines, where said lubricating oil composition comprises one or more additional lubricant base oils comprising polyalphaolefins and/or Fischer-Tropsch derived base oils. Further, the present invention relates to the use of the lubricating oil composition for lubricating a rotary air compressor.Type: ApplicationFiled: October 17, 2006Publication date: June 7, 2007Inventors: Nicholas Bell, Mitsuhiro Nagakari, Peter Smith