Patents by Inventor Nicholas Bell

Nicholas Bell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12584883
    Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.
    Type: Grant
    Filed: March 24, 2021
    Date of Patent: March 24, 2026
    Assignee: Cambridge Enterprise Limited
    Inventors: Ulrich Keyser, Nicholas Bell, Tim Liedl, Marc Ablay, Caterina Ducati
  • Patent number: 11202589
    Abstract: A system and method for assessing blood flow include: an ocular lens; a light source; a digital video camera; a biosensor; a trigger; and a computer. The ocular lens is for viewing a fundus of an eye. The light source is for illuminating the fundus. The digital video camera is for imaging the fundus. The biosensor is for sensing a pulse waveform. The computer is configured for: recording input frames and pulse waveform data in response to an input from the trigger; defining a low-pass frequency and a high-pass frequency from the pulse waveform data; stabilizing the input frames; enhancing contrast of the input frames; separating the input frames into sub-channels; conducting eulerian video magnification for color amplification using the inputs of image sampling rate, the low-pass frequency, the high-pass frequency, and an amplification factor; reconstructing the sub-channels into output frames; and combining the output frames with the input frames.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: December 21, 2021
    Assignee: University of Kentucky Research Foundation
    Inventors: Romulo Albuquerque, Nicholas Bell, Paras Vora
  • Publication number: 20210341421
    Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.
    Type: Application
    Filed: March 24, 2021
    Publication date: November 4, 2021
    Inventors: Ulrich KEYSER, Nicholas BELL, Tim LIEDL, Marc ABLAY, Caterina DUCATI
  • Patent number: 10983091
    Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: April 20, 2021
    Assignee: Cambridge Enterprise Limited
    Inventors: Ulrich Keyser, Nicholas Bell, Tim Liedl, Marc Ablay, Caterina Ducati
  • Publication number: 20190265194
    Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.
    Type: Application
    Filed: May 6, 2019
    Publication date: August 29, 2019
    Inventors: Ulrich KEYSER, Nicholas BELL, Tim LIEDL, Marc ABLAY, Caterina DUCATI
  • Patent number: 10330639
    Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: June 25, 2019
    Assignee: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Ulrich Keyser, Nicholas Bell, Tim Liedl, Marc Ablay, Caterina Ducati
  • Publication number: 20190159707
    Abstract: A system and method for assessing blood flow include: an ocular lens; a light source; a digital video camera; a biosensor; a trigger; and a computer. The ocular lens is for viewing a fundus of an eye. The light source is for illuminating the fundus. The digital video camera is for imaging the fundus. The biosensor is for sensing a pulse waveform. The computer is configured for: recording input frames and pulse waveform data in response to an input from the trigger; defining a low-pass frequency and a high-pass frequency from the pulse waveform data; stabilizing the input frames; enhancing contrast of the input frames; separating the input frames into sub-channels; conducting eulerian video magnification for color amplification using the inputs of image sampling rate, the low-pass frequency, the high-pass frequency, and an amplification factor; reconstructing the sub-channels into output frames; and combining the output frames with the input frames.
    Type: Application
    Filed: November 30, 2018
    Publication date: May 30, 2019
    Inventors: Romulo Albuquerque, Nicholas Bell, Paras Vora
  • Publication number: 20140291153
    Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.
    Type: Application
    Filed: December 6, 2012
    Publication date: October 2, 2014
    Inventors: Ulrich Keyser, Nicholas Bell, Tim Liedl, Marc Ablay, Caterina Ducati
  • Patent number: 7399985
    Abstract: A detection system for determining material level in a container where the container has an opening and an optical window mounted to the opening. A sensor element is mounted to the container adjacent the window. The sensor element has an optical emitter and an optical receiver positioned to form a triangular vertex with the material surface level within the container.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: July 15, 2008
    Assignee: DataOnline, L.L.C.
    Inventors: Walter Mruk, Martin Adams, William Kilkerr, Nicholas Bell, Robert Barnacle
  • Publication number: 20080011970
    Abstract: A detection system for determining material level in a container where the container has an opening and an optical window mounted to the opening. A sensor element is mounted to the container adjacent the window. The sensor element has an optical emitter and an optical receiver positioned to form a triangular vertex with the material surface level within the container.
    Type: Application
    Filed: July 13, 2006
    Publication date: January 17, 2008
    Applicant: DATAONLINE, L.L.C.
    Inventors: Walter MRUK, Martin ADAMS, William KILKERR, Nicholas BELL, Robert BARNACLE
  • Publication number: 20070129268
    Abstract: A lubricating oil composition is provided containing one or more hydrocarbyl-substituted aromatic lubricant base oils in combination with (a) one or more phenyl-naphthylamines, and (b) one or more diphenyl amines, where said lubricating oil composition comprises one or more additional lubricant base oils comprising polyalphaolefins and/or Fischer-Tropsch derived base oils. Further, the present invention relates to the use of the lubricating oil composition for lubricating a rotary air compressor.
    Type: Application
    Filed: October 17, 2006
    Publication date: June 7, 2007
    Inventors: Nicholas Bell, Mitsuhiro Nagakari, Peter Smith