Abstract: Disclosed herein are compounds and methods for educing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V.

Abstract: Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V.

Abstract: A user interface element for a diagnostic ultrasound system including a user determined seed point, a perimeter defining a closed region of similar echoic intensity surrounding the seed point, here that region corresponds to a cross section through a physical feature within a body, a first calculated value being an area of said closed region, a second calculated value being a volume of said physical feature, calculated using preselected assumptions about the shape of the physical feature, wherein the perimeter is user adjustable.

Abstract: A hand held ultrasound scanning apparatus of a type able to perform multiple scan modes and a hand held display and processing unit able to receive and display ultrasound scanline data, having a control for initiation and termination of ultrasound scanning where further operation of the same control causes the scan mode in use by the apparatus to move progressively through the available scan modes. The scan modes are selected from B-mode, M-mode, Gated Doppler, Power Doppler, Pulsed Wave Doppler, Color Doppler, Duplex Doppler, and 3D volume imaging.

Abstract: A method and system for remote management of a hand held medical device of a type which does not include a physical keyboard or a large display screen including connectable hardware providing a communications channel between the device and a remote computer system to provide a fully featured interface, with a full sized screen and keyboard, for use when manipulating data from the medical device.