Patents by Inventor Nicholas Boylan

Nicholas Boylan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220175690
    Abstract: This invention provides polymeric nanoparticles presenting non-conjugated BBB-crossing ligands on their surfaces, compositions and methods of use thereof, as well as non-conjugation methods to produce nanoparticles having BBB-crossing agents on their surfaces.
    Type: Application
    Filed: November 16, 2021
    Publication date: June 9, 2022
    Inventors: Bin Wu, Nicholas Boylan, Zimeng Wang, Jieni Xu
  • Publication number: 20220175689
    Abstract: This invention provides polymeric nanoparticles presenting non-conjugated BBB-crossing ligands on their surfaces, compositions and methods of use thereof, as well as non-conjugation methods to produce nanoparticles having BBB-crossing agents on their surfaces.
    Type: Application
    Filed: November 16, 2021
    Publication date: June 9, 2022
    Inventors: Bin Wu, Nicholas Boylan, Zimeng Wang, Jieni XU
  • Publication number: 20220142935
    Abstract: This invention provides a pharmaceutical composition comprising an agent that can bind Siglec receptors on cell surface. This invention also provides the method of preparing said pharmaceutical composition and the use thereof.
    Type: Application
    Filed: October 5, 2021
    Publication date: May 12, 2022
    Inventors: Bin Wu, Zimeng Wang, Nicholas Boylan, Jieni Xu
  • Publication number: 20210196829
    Abstract: Nanoparticles formed by emulsion of one or more core polymers, one or more surface altering materials, and one or more low molecular weight emulsifiers have been developed. The particles are made by dissolving the one or more core polymers in an organic solvent, adding the solution of the one or more core polymers to an aqueous solution or suspension of the emulsifier to form an emulsion, and then adding the emulsion to a second solution or suspension of the emulsifier to effect formation of the nanoparticles.
    Type: Application
    Filed: February 24, 2021
    Publication date: July 1, 2021
    Inventors: Justin Hanes, Qingguo Xu, Nicholas Boylan
  • Publication number: 20170209374
    Abstract: The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.
    Type: Application
    Filed: September 12, 2016
    Publication date: July 27, 2017
    Inventors: Donald Parson, Mir M. Ali, Nicholas Boylan
  • Publication number: 20170049709
    Abstract: The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include methods of making and using such nanoparticles.
    Type: Application
    Filed: August 19, 2016
    Publication date: February 23, 2017
    Inventors: Allen Horhota, Young-ho Song, Ujjwal Joshi, Nicholas Boylan, Matthew Simmons
  • Publication number: 20140329913
    Abstract: Nanoparticles formed by emulsion of one or more core polymers, one or more surface altering materials, and one or more low molecular weight emulsifiers have been developed. The particles are made by dissolving the one or more core polymers in an organic solvent, adding the solution of the one or more core polymers to an aqueous solution or suspension of the emulsifier to form an emulsion, and then adding the emulsion to a second solution or suspension of the emulsifier to effect formation of the nanoparticles. In the preferred embodiment, the molecular weight of the emulsifiers is less than 1500, 1300, 1200, 1000, 800, 600, or 500 amu. Preferred emulsifiers include cholic acid sodium salt, dioctyl sulfosuccinate sodium, hexadecyltrimethyl ammonium bromide, saponin, TWEEN® 20, TWEEN® 80, and sugar esters. The surface altering materials are present in an amount effective to make the surface charge of the particles neutral or essentially neutral when the one or more emulsifiers are charged.
    Type: Application
    Filed: December 14, 2012
    Publication date: November 6, 2014
    Applicant: The Johns Hopkins University
    Inventors: Justin Hanes, Qingguo Xu, Nicholas Boylan