Patents by Inventor Nicholas C. Masiello

Nicholas C. Masiello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODUCTION OF FC FRAGMENTS
    Publication number: 20170129966
    Abstract: In one aspect, the disclosure provides cells and transgenic non-human mammals for the production of Fc fragments, as well as compositions and uses thereof.
    Type: Application
    Filed: June 2, 2015
    Publication date: May 11, 2017
    Applicant: Laboratoire Français du Fractionnement et des Biotechnologies
    Inventor: Nicholas C. Masiello
  • FORMULATIONS OF LIQUID STABLE ANTITHROMBIN
    Publication number: 20160129115
    Abstract: In one aspect, the invention provides liquid stable formulations of antithrombin.
    Type: Application
    Filed: June 19, 2015
    Publication date: May 12, 2016
    Applicant: LFB USA, Inc.
    Inventors: Gerald R. Magneson, Greg J. Allard, Nicholas C. Masiello, Usha S. Patel, Lauren K. Fontana, Joseph L. Pearce, Jerry A. Grandoni
  • FORMULATIONS THAT STABILIZE PROTEINS
    Publication number: 20140242182
    Abstract: In one aspect, the disclosure provides formulations that stabilize proteins, wherein the formulations comprise a buffer. In some embodiments, the buffer comprises potassium mono-hydrogen-phosphate and potassium di-hydrogen-phosphate, or the buffer comprises sodium mono-hydrogen-phosphate and sodium di-hydrogen-phosphate. In some embodiments, the protein is a therapeutic protein. In some embodiments, the therapeutic protein is antithrombin.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 28, 2014
    Applicant: rEVO Biologics, Inc
    Inventors: Sean A. Evans, Greg J. Allard, Nicholas C. Masiello
  • FORMULATIONS OF LIQUID STABLE ANTITHROMBIN
    Publication number: 20110082083
    Abstract: In one aspect, the invention provides liquid stable formulations of antithrombin.
    Type: Application
    Filed: May 3, 2010
    Publication date: April 7, 2011
    Applicant: GTC Biotherapeutics, Inc.
    Inventors: Gerald R. Magneson, Greg J. Allard, Nicholas C. Masiello, Usha S. Patel, Lauren K. Fontana, Joseph L. Pearce, Jerry A. Grandoni
  • Protein purification
    Patent number: 5179199
    Abstract: A method of removing an organic solvent from a mixture that includes a compound having a polypeptide segment and the organic solvent, the method including the steps of contacting the mixture with an ion exchange resin under conditions that allow the compound to bond to the resin; and washing the resin with a first aqueous solution that elutes the organic solvent from the resin while allowing the compound to remain bound to the resin.
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: January 12, 1993
    Assignee: Genzyme Corporation
    Inventors: James R. Zabrecky, Nicholas C. Masiello
  • Cell encoding recombinant human erythropoietin
    Patent number: 4954437
    Abstract: A rodent epithelioid cell transformed with a recombinant DNA vector including a DNA sequence encoding human erythropoietin, the transformed cell being capable of producing N-linked and O-linked glycosylated human erythropoietin.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: September 4, 1990
    Assignee: Integrated Genetics, Inc.
    Inventors: Anton K. Beck, Raymond M. Withy, James R. Zabrecky, Nicholas C. Masiello